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Study · Animal study (in vivo) · mouse · 2016

8 results

Chronic stress-induced memory deficits are reversed by regular exercise via AMPK-mediated BDNF induction.

Kim DM, Leem YH

Neuroscience11 Mar 2016Cited by 93 (Europe PMC)

PMID26975895 (opens in a new tab)DOI10.1016/j.neuroscience.2016.03.019 (opens in a new tab)PepBankPUB-26975895
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice, AICAR injections enhanced alternation in the Y-maze test.

    In plain wordsIn mice, AICAR injections increased alternation in the Y-maze test.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseY-maze alternation
    Study

    mousen: not reported in source

    chronic stress model
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitoneal · 7 daysAs given in this study (mouse).

    Source sentences

    Summary
    A 7-day period of AICAR intraperitoneal injections enhanced alternation in the Y-maze test and reduced escape latency in water maze test, along with enhanced phospho-AMPK and BDNF levels in the hippocampus.
    1 context sentence
    Summary · context
    The intraperitoneal injection of Compound C every 4 days during exercise intervention diminished exercise-induced enhancement of memory improvement during the water maze test in chronically stressed mice.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice, AICAR injections reduced escape latency in the water maze test.

    In plain wordsIn mice, AICAR injections reduced the time needed to escape in the water maze test.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseWater maze escape latency
    Study

    mousen: not reported in source

    chronic stress model
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitoneal · 7 daysAs given in this study (mouse).

    Source sentences

    Summary
    A 7-day period of AICAR intraperitoneal injections enhanced alternation in the Y-maze test and reduced escape latency in water maze test, along with enhanced phospho-AMPK and BDNF levels in the hippocampus.
    1 context sentence
    Summary · context
    The intraperitoneal injection of Compound C every 4 days during exercise intervention diminished exercise-induced enhancement of memory improvement during the water maze test in chronically stressed mice.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In mice, AICAR injections enhanced hippocampal phospho-AMPK levels.

    In plain wordsIn mice, AICAR injections increased hippocampal phospho-AMPK levels.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseHippocampal phospho-AMPK levels
    Study

    mousen: not reported in source

    chronic stress model
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitoneal · 7 daysAs given in this study (mouse).

    Source sentences

    Summary
    A 7-day period of AICAR intraperitoneal injections enhanced alternation in the Y-maze test and reduced escape latency in water maze test, along with enhanced phospho-AMPK and BDNF levels in the hippocampus.
    1 context sentence
    Summary · context
    The intraperitoneal injection of Compound C every 4 days during exercise intervention diminished exercise-induced enhancement of memory improvement during the water maze test in chronically stressed mice.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In mice, AICAR injections enhanced hippocampal BDNF levels.

    In plain wordsIn mice, AICAR injections increased hippocampal BDNF levels.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseHippocampal BDNF levels
    Study

    mousen: not reported in source

    chronic stress model
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitoneal · 7 daysAs given in this study (mouse).

    Source sentences

    Summary
    A 7-day period of AICAR intraperitoneal injections enhanced alternation in the Y-maze test and reduced escape latency in water maze test, along with enhanced phospho-AMPK and BDNF levels in the hippocampus.
    1 context sentence
    Summary · context
    The intraperitoneal injection of Compound C every 4 days during exercise intervention diminished exercise-induced enhancement of memory improvement during the water maze test in chronically stressed mice.
  5. 05LabIn vitro (cells)Mechanism

    In hippocampal primary culture, AICAR increased phospho-AMPK levels in a dose-dependent manner.

    In plain wordsIn cells, AICAR increased phospho-AMPK levels as the dose increased.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseCulture phospho-AMPK levels
    Study

    n: not reported in source

    hippocampal primary culture
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In hippocampal primary culture, phosphorylated-AMPK (phospho-AMPK) and BDNF levels were enhanced in a dose-dependent manner by 5-amimoimidazole-4-carboxamide riboside (AICAR) treatment, and AICAR-treated increase was blocked by Compound C.
  6. 06LabIn vitro (cells)Mechanism

    In hippocampal primary culture, AICAR increased BDNF levels in a dose-dependent manner.

    In plain wordsIn cells, AICAR increased BDNF levels as the dose increased.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseCulture BDNF levels
    Study

    n: not reported in source

    hippocampal primary culture
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In hippocampal primary culture, phosphorylated-AMPK (phospho-AMPK) and BDNF levels were enhanced in a dose-dependent manner by 5-amimoimidazole-4-carboxamide riboside (AICAR) treatment, and AICAR-treated increase was blocked by Compound C.

Studies that did not test the peptide alone2

In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking AICAR (acadesine).

  1. 07LabNot a test of AICAR (acadesine) aloneIn vitro (cells)Mechanism

    In hippocampal primary culture, Compound C blocked the AICAR-induced increase in phospho-AMPK levels.

    In plain wordsIn cells, Compound C blocked the increase in phospho-AMPK levels induced by AICAR.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseCompound C blockade of phospho-AMPK response
    Study

    n: not reported in source

    hippocampal primary culture
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    In hippocampal primary culture, phosphorylated-AMPK (phospho-AMPK) and BDNF levels were enhanced in a dose-dependent manner by 5-amimoimidazole-4-carboxamide riboside (AICAR) treatment, and AICAR-treated increase was blocked by Compound C.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

  2. 08LabNot a test of AICAR (acadesine) aloneIn vitro (cells)Mechanism

    In hippocampal primary culture, Compound C blocked the AICAR-induced increase in BDNF levels.

    In plain wordsIn cells, Compound C blocked the increase in BDNF levels induced by AICAR.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseCompound C blockade of BDNF response
    Study

    n: not reported in source

    hippocampal primary culture
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    In hippocampal primary culture, phosphorylated-AMPK (phospho-AMPK) and BDNF levels were enhanced in a dose-dependent manner by 5-amimoimidazole-4-carboxamide riboside (AICAR) treatment, and AICAR-treated increase was blocked by Compound C.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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