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Study · Not a test of the peptide alone · 2016

1 result

Pretreatment of rats with increased bioavailable berberine attenuates cerebral ischemia-reperfusion injury via down regulation of adenosine-5'monophosphate kinase activity.

Chen W, Wei S, Yu Y, Xue H, Yao F, Zhang M, Xiao J, Hatch GM, Chen L

European journal of pharmacology5 Mar 2016Cited by 23 (Europe PMC)

PMID26957053 (opens in a new tab)DOI10.1016/j.ejphar.2016.03.015 (opens in a new tab)PepBankPUB-26957053
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone1

In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking AICAR (acadesine).

  1. 01LabNot a test of AICAR (acadesine) aloneIn vitro (cells)Mechanism

    In PC12 cells, AICAR attenuated the protective effect of HGSD serum against apoptosis.

    In plain wordsIn cells, AICAR reduced protection against cell death from HGSD serum compared with serum without AICAR.

    Peptide
    AICAR (acadesine)
    Outcome
    DecreaseHGSD serum protection against apoptosis
    Study

    n: not reported in source

    PC12 cells exposed to H2O2 and HGSD serum
    Comparator
    HGSD serum without AICAR
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    The presence of AMPK activator (AICAR) attenuated whereas AMPK inhibitor (Compound C) augmented the protective effect of HGSD serum on PC12 cell apoptosis.
    1 context sentence
    Summary · context
    To further probe for the mechanism of beneficial effect of HGSD, PC12 cells were incubated with serum from control or HGSD pretreated animals, incubated with 300μM H2O2 to induce apoptosis.

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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