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Study · Animal study (in vivo) · rat · 2016

3 results

Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission.

Volkova A, Shadrina M, Kolomin T, Andreeva L, Limborska S, Myasoedov N, Slominsky P

Frontiers in pharmacology18 Feb 2016Cited by 6 (Europe PMC)

PMID26924987 (opens in a new tab)PMCIDPMC4757669 (opens in a new tab)DOI10.3389/fphar.2016.00031 (opens in a new tab)PepBankPUB-26924987
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Summary

Clinical studies have shown the similarity of the spectrum of physiological effects of Selank and classical benzodiazepines, such as diazepam and phenazepam. These data suggest that there is a similar basis of their mechanism of action. To test this hypothesis we studied the effect of Selank and GABA on the expression of genes involved in neurotransmission. We analyzed the expression of 84 genes involved in neurotransmission (e.g., major subunit of the GABA receptor, transporters, ion channels, dopamine, and serotonin receptors) in the frontal cortex of rats 1 and 3 h after the administration of Selank or GABA (300 μg/kg) using real-time PCR method. We found significant changes in the expression of 45 genes 1 h after the administration of the compounds. Three hours after Selank or GABA administration, 22 genes changed their expression. We found positive correlation between the changes in genes expression within 1 h after administration of Selank or GABA. Our results showed that Selank caused a number of alterations in the expression of genes involved in neurotransmission. The data obtained indicate that Selank is characterized by its complex effects on nerve cells, and one of its possible molecular mechanisms is associated with allosteric modulation of the GABAergic system.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rat frontal cortex, significant changes in expression of 45 neurotransmission genes were found 1 h after administration of Selank or GABA.

    In plain wordsIn rats, Selank or GABA changed the activity of 45 brain genes one hour after dosing.

    Peptide
    Selank
    Outcome
    MixedGene expression changes 1 h after administration
    Study

    ratn: not reported in source

    Frontal cortex, real-time PCR of 84 neurotransmission genes
    Outcome group
    Gene expression · Nervous system and cognition
    Studied dose
    300 μg/kg · 1 hAs given in this study (rat).

    Measurements

    Genes with altered expression
    45 genes
    1 h after administration

    Source sentences

    Summary
    We found significant changes in the expression of 45 genes 1 h after the administration of the compounds.
    1 context sentence
    Summary · context
    We analyzed the expression of 84 genes involved in neurotransmission (e.g., major subunit of the GABA receptor, transporters, ion channels, dopamine, and serotonin receptors) in the frontal cortex of rats 1 and 3 h after the administration of Selank or GABA (300 μg/kg) using real-time PCR method.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rat frontal cortex, 22 neurotransmission genes changed their expression 3 h after Selank or GABA administration.

    In plain wordsIn rats, 22 brain genes had changed activity three hours after Selank or GABA.

    Peptide
    Selank
    Outcome
    MixedGene expression changes 3 h after administration
    Study

    ratn: not reported in source

    Frontal cortex, real-time PCR of 84 neurotransmission genes
    Outcome group
    Gene expression · Nervous system and cognition
    Studied dose
    300 μg/kg · 3 hAs given in this study (rat).

    Measurements

    Genes with altered expression
    22 genes
    3 h after administration

    Source sentences

    Summary
    Three hours after Selank or GABA administration, 22 genes changed their expression.
    1 context sentence
    Summary · context
    We analyzed the expression of 84 genes involved in neurotransmission (e.g., major subunit of the GABA receptor, transporters, ion channels, dopamine, and serotonin receptors) in the frontal cortex of rats 1 and 3 h after the administration of Selank or GABA (300 μg/kg) using real-time PCR method.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rat frontal cortex, changes in gene expression 1 h after Selank correlated positively with those after GABA.

    In plain wordsIn rats, the gene changes after Selank were similar in pattern to those after GABA.

    Peptide
    Selank
    Outcome
    Not applicableCorrelation of Selank and GABA gene expression changes at 1 h
    Study

    ratn: not reported in source

    Frontal cortex, real-time PCR of 84 neurotransmission genes
    Outcome group
    Gene expression · Nervous system and cognition
    Studied dose
    300 μg/kgAs given in this study (rat).

    Source sentences

    Summary
    We found positive correlation between the changes in genes expression within 1 h after administration of Selank or GABA.
    1 context sentence
    Summary · context
    We analyzed the expression of 84 genes involved in neurotransmission (e.g., major subunit of the GABA receptor, transporters, ion channels, dopamine, and serotonin receptors) in the frontal cortex of rats 1 and 3 h after the administration of Selank or GABA (300 μg/kg) using real-time PCR method.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 19:08 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

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