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Study · Animal study (in vivo) · mouse · 2016

3 results

[Time course study of growth hormone releasing peptide-6-induced c-fos expression in neurons of feeding-related nuclei of hypothalamus].

Yu YJ, Dong J, Jiang ZY, Depoortere I

Sheng li xue bao : [Acta physiologica Sinica]1 Feb 2016

PMID26915318 (opens in a new tab)PepBankPUB-26915318
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In NMRI mice, GHRP‑6 significantly increased food intake, with a peak at 3 hours after injection.

    In plain wordsIn mice, GHRP‑6 increased food intake, with a peak at 3 hours after injection.

    Peptide
    GHRP-6
    Outcome
    IncreaseFood intake
    Study

    mousen: not reported in source

    NMRI mice
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    The results showed that GHRP-6 significantly increased the amount of food intake with a peak at 3 h after the GHRP-6 injection.
    1 context sentence
    Summary · context
    The present study was aimed to explore the effects of intraperitoneal injection of growth hormone releasing peptide-6 (GHRP-6), a ghrelin receptor agonist, on food intake and neuronal activity of feeding-related nuclei in the hypothalamus of NMRI mice.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In NMRI mice, GHRP‑6 could promote arcuate nucleus c-fos expression independently of food intake, with immunoreactive neurons peaking at 1 hour.

    In plain wordsIn mice, GHRP‑6 could increase arcuate nucleus c-fos expression independently of food intake, with a peak at 1 hour.

    Peptide
    GHRP-6
    Outcome
    IncreaseArcuate nucleus c-fos expression
    Study

    mousen: not reported in source

    NMRI mice
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Meanwhile, GHRP-6 could promote c-fos expression in the ARC and PVN independent of food intake, and the total number of c-fos immunoreactive neurons was peaked at 1 h after injection and then decreased gradually.
    1 context sentence
    Summary · context
    The present study was aimed to explore the effects of intraperitoneal injection of growth hormone releasing peptide-6 (GHRP-6), a ghrelin receptor agonist, on food intake and neuronal activity of feeding-related nuclei in the hypothalamus of NMRI mice.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In NMRI mice, GHRP‑6 could promote paraventricular nucleus c-fos expression independently of food intake, with immunoreactive neurons peaking at 1 hour.

    In plain wordsIn mice, GHRP‑6 could increase paraventricular nucleus c-fos expression independently of food intake, with a peak at 1 hour.

    Peptide
    GHRP-6
    Outcome
    IncreaseParaventricular nucleus c-fos expression
    Study

    mousen: not reported in source

    NMRI mice
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Meanwhile, GHRP-6 could promote c-fos expression in the ARC and PVN independent of food intake, and the total number of c-fos immunoreactive neurons was peaked at 1 h after injection and then decreased gradually.
    1 context sentence
    Summary · context
    The present study was aimed to explore the effects of intraperitoneal injection of growth hormone releasing peptide-6 (GHRP-6), a ghrelin receptor agonist, on food intake and neuronal activity of feeding-related nuclei in the hypothalamus of NMRI mice.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

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