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Study · Randomized controlled trial · n = 32 · 2016

2 results

Do we need oxytocin to treat schizophrenia? A randomized clinical trial.

Dagani J, Sisti D, Abelli M, Di Paolo L, Pini S, Raimondi S, Rocchi MB, Saviotti FM, Scocco P, Totaro S, Balestrieri M, de Girolamo G

Schizophrenia research14 Feb 2016Cited by 33 (Europe PMC)

PMID26883950 (opens in a new tab)DOI10.1016/j.schres.2016.02.011 (opens in a new tab)PepBankPUB-26883950
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In patients with schizophrenia on antipsychotics, intranasal oxytocin did not change PANSS scores differently from placebo.

    In plain wordsIn people with schizophrenia taking antipsychotics, nasal oxytocin did not change symptom scores more than placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changePositive and Negative Syndrome Scale scores
    Study

    n = 32

    Comparator
    Vehicle placebo
    Outcome group
    Psychiatric symptoms · Mental health and mood
    Studied dose
    40 IU once daily · intranasalAs given in this study (human).

    Source sentences

    Summary
    Positive and Negative Syndrome Scale scores showed no significant differences in treatment effects between the experimental group and controls.
    2 context sentences
    Summary · context
    We conducted an 8-month randomized, double-blind, controlled trial with a crossover design.
    Summary · context
    Patients were randomly assigned to either 40 International Units oxytocin once daily or a vehicle placebo group, in addition to their pre-study antipsychotic medication regimen.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In patients with schizophrenia on antipsychotics, intranasal oxytocin showed no treatment effects on any other rating scale used compared with placebo.

    In plain wordsIn people with schizophrenia taking antipsychotics, nasal oxytocin showed no effect on any other rating scale compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeOther psychopathological, psychosocial and neuropsychological rating scales
    Study

    n = 32

    Comparator
    Vehicle placebo
    Outcome group
    Psychiatric symptoms · Mental health and mood
    Studied dose
    40 IU once daily · intranasalAs given in this study (human).

    Source sentences

    Summary
    Furthermore, no treatment effects were shown in any of the rating scales used in this study.
    2 context sentences
    Summary · context
    We conducted an 8-month randomized, double-blind, controlled trial with a crossover design.
    Summary · context
    Patients were randomly assigned to either 40 International Units oxytocin once daily or a vehicle placebo group, in addition to their pre-study antipsychotic medication regimen.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · 1 completed · source ClinicalTrials.gov (opens in a new tab)

CompletedPhase 2NCT01699997

Oxytocin as Adjunctive Therapy for Schizophrenia

IRCCS Centro San Giovanni di Dio Fatebenefratellin = 32Jan 2014 to Nov 2015

Schizophrenia

Trial pageClinicalTrials.govUpdated 24 Feb 2016

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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