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Study · Animal study (in vivo) · guinea pig · 2016

13 results

Parathyroid hormone(1-34) exhibits more comprehensive effects than celecoxib in cartilage metabolism and maintaining subchondral bone micro-architecture in meniscectomized guinea pigs.

Dai MW, Chu JG, Tian FM, Song HP, Wang Y, Zhang YZ, Zhang L

Osteoarthritis and cartilage21 Jan 2016Cited by 23 (Europe PMC)

PMID26802547 (opens in a new tab)DOI10.1016/j.joca.2016.01.007 (opens in a new tab)PepBankPUB-26802547
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study13

13 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In meniscectomized guinea pigs, PTH partially inhibited cartilage degeneration relative to untreated meniscectomy.

    In plain wordsIn guinea pigs, PTH partly reduced cartilage degeneration compared with untreated meniscectomy.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    DecreaseOARSI cartilage degeneration score
    Study

    guinea pign: not reported in source

    Medial meniscectomy
    Comparator
    MNX
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    24 μg/kg, 5 days/week · subcutaneous injection · 12 weeksAs given in this study (guinea pig).

    Source sentences

    Summary
    OARSI scores indicated cartilage degeneration was partially inhibited by either CLX or PTH(1-34).
    2 context sentences
    Summary · context
    Forty-eight 3-month-old male Hartley albino guinea pigs received either sham or medial meniscectomy (MNX) operations.
    Summary · context
    One week after the procedure, meniscectomized animals began 12 weeks of treatment by oral administration of CLX (20 mg/kg, daily), subcutaneous injection of PTH (1-34) (24 μg/kg, 5 days/week), or normal saline for MNX group.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In meniscectomized guinea pigs, cartilage was thicker with PTH than with celecoxib.

    In plain wordsIn guinea pigs, cartilage was thicker with PTH than with celecoxib.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseCartilage thickness
    Study

    guinea pign: not reported in source

    Medial meniscectomy
    Comparator
    celecoxib
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    24 μg/kg, 5 days/week · subcutaneous injection · 12 weeksAs given in this study (guinea pig).

    Source sentences

    Summary
    Cartilage was significantly thicker in PTH(1-34)-treated animals than in CLX-treated animals.
    2 context sentences
    Summary · context
    Forty-eight 3-month-old male Hartley albino guinea pigs received either sham or medial meniscectomy (MNX) operations.
    Summary · context
    One week after the procedure, meniscectomized animals began 12 weeks of treatment by oral administration of CLX (20 mg/kg, daily), subcutaneous injection of PTH (1-34) (24 μg/kg, 5 days/week), or normal saline for MNX group.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In meniscectomized guinea pigs, PTH was associated with lower ADAMTS-4 expression than untreated meniscectomy.

    In plain wordsIn guinea pigs, PTH was linked to lower ADAMTS-4 expression than untreated meniscectomy.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    DecreaseADAMTS-4 expression
    Study

    guinea pign: not reported in source

    Medial meniscectomy
    Comparator
    MNX
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    24 μg/kg, 5 days/week · subcutaneous injection · 12 weeksAs given in this study (guinea pig).

    Source sentences

    Summary
    Both CLX and PTH(1-34) treatment were associated with lower ADAMTS-4 and periostin expression than MNX.
    2 context sentences
    Summary · context
    Forty-eight 3-month-old male Hartley albino guinea pigs received either sham or medial meniscectomy (MNX) operations.
    Summary · context
    One week after the procedure, meniscectomized animals began 12 weeks of treatment by oral administration of CLX (20 mg/kg, daily), subcutaneous injection of PTH (1-34) (24 μg/kg, 5 days/week), or normal saline for MNX group.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In meniscectomized guinea pigs, PTH was associated with lower periostin expression than untreated meniscectomy.

    In plain wordsIn guinea pigs, PTH was linked to lower periostin expression than untreated meniscectomy.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    DecreasePeriostin expression
    Study

    guinea pign: not reported in source

    Medial meniscectomy
    Comparator
    MNX
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    24 μg/kg, 5 days/week · subcutaneous injection · 12 weeksAs given in this study (guinea pig).

    Source sentences

    Summary
    Both CLX and PTH(1-34) treatment were associated with lower ADAMTS-4 and periostin expression than MNX.
    2 context sentences
    Summary · context
    Forty-eight 3-month-old male Hartley albino guinea pigs received either sham or medial meniscectomy (MNX) operations.
    Summary · context
    One week after the procedure, meniscectomized animals began 12 weeks of treatment by oral administration of CLX (20 mg/kg, daily), subcutaneous injection of PTH (1-34) (24 μg/kg, 5 days/week), or normal saline for MNX group.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In meniscectomized guinea pigs, MMP-13 expression was lower with PTH than with celecoxib.

    In plain wordsIn guinea pigs, MMP-13 expression was lower with PTH than with celecoxib.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    DecreaseMMP-13 expression
    Study

    guinea pign: not reported in source

    Medial meniscectomy
    Comparator
    celecoxib
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    24 μg/kg, 5 days/week · subcutaneous injection · 12 weeksAs given in this study (guinea pig).

    Source sentences

    Summary
    MMP-13 expression in PTH(1-34) group was significantly lower than that in CLX group.
    2 context sentences
    Summary · context
    Forty-eight 3-month-old male Hartley albino guinea pigs received either sham or medial meniscectomy (MNX) operations.
    Summary · context
    One week after the procedure, meniscectomized animals began 12 weeks of treatment by oral administration of CLX (20 mg/kg, daily), subcutaneous injection of PTH (1-34) (24 μg/kg, 5 days/week), or normal saline for MNX group.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In meniscectomized guinea pigs, AGG expression was higher with PTH than with celecoxib.

    In plain wordsIn guinea pigs, AGG expression was higher with PTH than with celecoxib.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseAGG expression
    Study

    guinea pign: not reported in source

    Medial meniscectomy
    Comparator
    celecoxib
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    24 μg/kg, 5 days/week · subcutaneous injection · 12 weeksAs given in this study (guinea pig).

    Source sentences

    Summary
    However, AGG expression and the ratio of Col-II/MMP-13 expression in PTH(1-34) group were significantly higher than in the CLX group.
    2 context sentences
    Summary · context
    Forty-eight 3-month-old male Hartley albino guinea pigs received either sham or medial meniscectomy (MNX) operations.
    Summary · context
    One week after the procedure, meniscectomized animals began 12 weeks of treatment by oral administration of CLX (20 mg/kg, daily), subcutaneous injection of PTH (1-34) (24 μg/kg, 5 days/week), or normal saline for MNX group.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In meniscectomized guinea pigs, the Col-II/MMP-13 ratio was higher with PTH than with celecoxib.

    In plain wordsIn guinea pigs, the Col-II/MMP-13 ratio was higher with PTH than with celecoxib.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseCol-II/MMP-13 expression ratio
    Study

    guinea pign: not reported in source

    Medial meniscectomy
    Comparator
    celecoxib
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    24 μg/kg, 5 days/week · subcutaneous injection · 12 weeksAs given in this study (guinea pig).

    Source sentences

    Summary
    However, AGG expression and the ratio of Col-II/MMP-13 expression in PTH(1-34) group were significantly higher than in the CLX group.
    2 context sentences
    Summary · context
    Forty-eight 3-month-old male Hartley albino guinea pigs received either sham or medial meniscectomy (MNX) operations.
    Summary · context
    One week after the procedure, meniscectomized animals began 12 weeks of treatment by oral administration of CLX (20 mg/kg, daily), subcutaneous injection of PTH (1-34) (24 μg/kg, 5 days/week), or normal saline for MNX group.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In meniscectomized guinea pigs, subchondral BMD was higher with PTH than with untreated meniscectomy.

    In plain wordsIn guinea pigs, bone density was higher with PTH than with untreated meniscectomy.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseSubchondral BMD versus MNX
    Study

    guinea pign: not reported in source

    Medial meniscectomy
    Comparator
    MNX
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    24 μg/kg, 5 days/week · subcutaneous injection · 12 weeksAs given in this study (guinea pig).

    Source sentences

    Summary
    Micro-CT analysis showed BMD, BV/TV, and Tb.Th levels to be significantly lower in the MNX group and CLX groups than in the sham group, but these parameters were significantly higher in the PTH(1-34) group than in either the MNX group or CLX group.
    2 context sentences
    Summary · context
    Forty-eight 3-month-old male Hartley albino guinea pigs received either sham or medial meniscectomy (MNX) operations.
    Summary · context
    One week after the procedure, meniscectomized animals began 12 weeks of treatment by oral administration of CLX (20 mg/kg, daily), subcutaneous injection of PTH (1-34) (24 μg/kg, 5 days/week), or normal saline for MNX group.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In meniscectomized guinea pigs, subchondral BMD was higher with PTH than with celecoxib.

    In plain wordsIn guinea pigs, bone density was higher with PTH than with celecoxib.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseSubchondral BMD versus celecoxib
    Study

    guinea pign: not reported in source

    Medial meniscectomy
    Comparator
    celecoxib
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    24 μg/kg, 5 days/week · subcutaneous injection · 12 weeksAs given in this study (guinea pig).

    Source sentences

    Summary
    Micro-CT analysis showed BMD, BV/TV, and Tb.Th levels to be significantly lower in the MNX group and CLX groups than in the sham group, but these parameters were significantly higher in the PTH(1-34) group than in either the MNX group or CLX group.
    2 context sentences
    Summary · context
    Forty-eight 3-month-old male Hartley albino guinea pigs received either sham or medial meniscectomy (MNX) operations.
    Summary · context
    One week after the procedure, meniscectomized animals began 12 weeks of treatment by oral administration of CLX (20 mg/kg, daily), subcutaneous injection of PTH (1-34) (24 μg/kg, 5 days/week), or normal saline for MNX group.
  10. 10AnimalAnimal study (in vivo)Efficacy outcome

    In meniscectomized guinea pigs, BV/TV was higher with PTH than with untreated meniscectomy.

    In plain wordsIn guinea pigs, bone volume fraction was higher with PTH than with untreated meniscectomy.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseBV/TV versus MNX
    Study

    guinea pign: not reported in source

    Medial meniscectomy
    Comparator
    MNX
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    24 μg/kg, 5 days/week · subcutaneous injection · 12 weeksAs given in this study (guinea pig).

    Source sentences

    Summary
    Micro-CT analysis showed BMD, BV/TV, and Tb.Th levels to be significantly lower in the MNX group and CLX groups than in the sham group, but these parameters were significantly higher in the PTH(1-34) group than in either the MNX group or CLX group.
    2 context sentences
    Summary · context
    Forty-eight 3-month-old male Hartley albino guinea pigs received either sham or medial meniscectomy (MNX) operations.
    Summary · context
    One week after the procedure, meniscectomized animals began 12 weeks of treatment by oral administration of CLX (20 mg/kg, daily), subcutaneous injection of PTH (1-34) (24 μg/kg, 5 days/week), or normal saline for MNX group.
  11. 11AnimalAnimal study (in vivo)Efficacy outcome

    In meniscectomized guinea pigs, BV/TV was higher with PTH than with celecoxib.

    In plain wordsIn guinea pigs, bone volume fraction was higher with PTH than with celecoxib.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseBV/TV versus celecoxib
    Study

    guinea pign: not reported in source

    Medial meniscectomy
    Comparator
    celecoxib
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    24 μg/kg, 5 days/week · subcutaneous injection · 12 weeksAs given in this study (guinea pig).

    Source sentences

    Summary
    Micro-CT analysis showed BMD, BV/TV, and Tb.Th levels to be significantly lower in the MNX group and CLX groups than in the sham group, but these parameters were significantly higher in the PTH(1-34) group than in either the MNX group or CLX group.
    2 context sentences
    Summary · context
    Forty-eight 3-month-old male Hartley albino guinea pigs received either sham or medial meniscectomy (MNX) operations.
    Summary · context
    One week after the procedure, meniscectomized animals began 12 weeks of treatment by oral administration of CLX (20 mg/kg, daily), subcutaneous injection of PTH (1-34) (24 μg/kg, 5 days/week), or normal saline for MNX group.
  12. 12AnimalAnimal study (in vivo)Efficacy outcome

    In meniscectomized guinea pigs, trabecular thickness was higher with PTH than with untreated meniscectomy.

    In plain wordsIn guinea pigs, bone struts were thicker with PTH than with untreated meniscectomy.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseTrabecular thickness versus MNX
    Study

    guinea pign: not reported in source

    Medial meniscectomy
    Comparator
    MNX
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    24 μg/kg, 5 days/week · subcutaneous injection · 12 weeksAs given in this study (guinea pig).

    Source sentences

    Summary
    Micro-CT analysis showed BMD, BV/TV, and Tb.Th levels to be significantly lower in the MNX group and CLX groups than in the sham group, but these parameters were significantly higher in the PTH(1-34) group than in either the MNX group or CLX group.
    2 context sentences
    Summary · context
    Forty-eight 3-month-old male Hartley albino guinea pigs received either sham or medial meniscectomy (MNX) operations.
    Summary · context
    One week after the procedure, meniscectomized animals began 12 weeks of treatment by oral administration of CLX (20 mg/kg, daily), subcutaneous injection of PTH (1-34) (24 μg/kg, 5 days/week), or normal saline for MNX group.
  13. 13AnimalAnimal study (in vivo)Efficacy outcome

    In meniscectomized guinea pigs, trabecular thickness was higher with PTH than with celecoxib.

    In plain wordsIn guinea pigs, bone struts were thicker with PTH than with celecoxib.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseTrabecular thickness versus celecoxib
    Study

    guinea pign: not reported in source

    Medial meniscectomy
    Comparator
    celecoxib
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    24 μg/kg, 5 days/week · subcutaneous injection · 12 weeksAs given in this study (guinea pig).

    Source sentences

    Summary
    Micro-CT analysis showed BMD, BV/TV, and Tb.Th levels to be significantly lower in the MNX group and CLX groups than in the sham group, but these parameters were significantly higher in the PTH(1-34) group than in either the MNX group or CLX group.
    2 context sentences
    Summary · context
    Forty-eight 3-month-old male Hartley albino guinea pigs received either sham or medial meniscectomy (MNX) operations.
    Summary · context
    One week after the procedure, meniscectomized animals began 12 weeks of treatment by oral administration of CLX (20 mg/kg, daily), subcutaneous injection of PTH (1-34) (24 μg/kg, 5 days/week), or normal saline for MNX group.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

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