Skip to content

Study · In vitro (cell-free) · 2016

3 results

New studies about the insertion mechanism of Thymosin α1 in negative regions of model membranes as starting point of the bioactivity.

Mandaliti W, Nepravishta R, Sinibaldi Vallebona P, Pica F, Garaci E, Paci M

Amino acids22 Jan 2016Cited by 12 (Europe PMC)

PMID26801937 (opens in a new tab)DOI10.1007/s00726-016-2169-4 (opens in a new tab)PepBankPUB-26801937
Publisher pagePubMedAsk about this study
Jump to 3 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cell-free)Mechanism

    In micelles of dodecylphosphocholine, which expose choline polar heads, thymosin alpha‑1 interacted in a non-specific way.

    In plain wordsIn lab tests, thymosin alpha‑1 interacted in a non-specific way with model membranes that expose choline heads.

    Peptide
    Thymosin alpha-1
    Outcome
    Not applicableInteraction with phosphocholine micelles
    Study

    n: not reported in source

    Dodecylphosphocholine and mixed dodecylphosphocholine-sodium dodecylsulphate micelles
    Outcome group
    Receptor activity and mechanism · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Thymosin α1 in phospholipidic membrane exposing choline polar heads interacts by aspecific modality
    1 context sentence
    Summary · context
    An investigation of its interaction both with micelles of dodecylphosphocholine alone and with mixed dodecylphosphocholine-sodium dodecylsulphate micelles is here reported.
  2. 02LabIn vitro (cell-free)Mechanism

    In mixed dodecylphosphocholine-sodium dodecylsulphate micelles, thymosin alpha‑1 inserted into the hydrophobic micelle region with a conformation like that in sodium dodecylsulphate micelles.

    In plain wordsIn lab tests, thymosin alpha‑1 inserted into the core of negatively charged model membranes.

    Peptide
    Thymosin alpha-1
    Outcome
    Not applicableInsertion into mixed micelles
    Study

    n: not reported in source

    Dodecylphosphocholine and mixed dodecylphosphocholine-sodium dodecylsulphate micelles
    Outcome group
    Receptor activity and mechanism · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    in the mixed dodecylphosphocholine-sodium dodecylsulphate micelles an insertion in the micellar hydrophobic region conformationally similar to that found in sodium dodecylsulphate micelles occurs.
    1 context sentence
    Summary · context
    An investigation of its interaction both with micelles of dodecylphosphocholine alone and with mixed dodecylphosphocholine-sodium dodecylsulphate micelles is here reported.
  3. 03LabIn vitro (cell-free)Mechanism

    In mixed micelles, thymosin alpha‑1 inserted and structured in preferred regions when the membrane models were negatively charged.

    In plain wordsIn lab tests, thymosin alpha‑1 inserted into preferred regions of negatively charged model membranes.

    Peptide
    Thymosin alpha-1
    Outcome
    Not applicablePreferred insertion regions in negatively charged membrane models
    Study

    n: not reported in source

    Dodecylphosphocholine and mixed dodecylphosphocholine-sodium dodecylsulphate micelles
    Outcome group
    Receptor activity and mechanism · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In presence of mixed micelles the insertion and structuration occur in preferred regions when the membrane models are negatively charged.
    1 context sentence
    Summary · context
    An investigation of its interaction both with micelles of dodecylphosphocholine alone and with mixed dodecylphosphocholine-sodium dodecylsulphate micelles is here reported.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

PepBank is a research reference. Talk to a doctor before you use any peptide.