Meta-analysis and association of two common polymorphisms of the human oxytocin receptor gene in autism spectrum disorder.

Kranz TM, Kopp M, Waltes R, Sachse M, Duketis E, Jarczok TA, Degenhardt F, Görgen K, Meyer J, Freitag CM, Chiocchetti AG

Autism research : official journal of the International Society for Autism Research20 Jan 2016Cited by 38 (Europe PMC)

PMID26788924DOI10.1002/aur.1597PepBankPUB-26788924

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone5

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

01HumanNot a test of Oxytocin aloneSystematic reviewOther
In a meta-analysis of four studies, the rs237889 minor allele was associated with autism spectrum disorder.
In plain wordsPooling four studies, a variant of the oxytocin receptor gene was linked to autism spectrum disorder.
Peptide
Oxytocin
Outcome
IncreaseOXTR rs237889 association with ASD, meta-analysis of four studies
Study
n = 542
Outcome group
Genetic association · Mental health and mood
Measurements
Odds ratio
1.12 OR
rs237889, meta-analysis
Source sentences
Summary
Still, in a meta-analysis comprising four different studies including the two unreported German data sets (N = 542 families), this finding was confirmed (OR = 1.12; CI95 = 1.01-1.24, random effects P = 0.012).
1 context sentence(design, population, supporting numbers)
Summary · context
Here, we genotyped and tested two additional variants (rs237889 and rs237897) for association with ASD in two German predominantly high-functioning ASD samples.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-2678892403
02HumanNot a test of Oxytocin aloneObservational studyOther
In German sample 1, the minor A allele of OXTR variant rs237889 was nominally over-transmitted in autism spectrum disorder.
In plain wordsIn one German family sample, a variant of the oxytocin receptor gene was passed on more often to people with autism.
Peptide
Oxytocin
Outcome
IncreaseOXTR rs237889 A allele over-transmission in ASD, sample 1
Study
n: not reported in source
Outcome group
Genetic association · Mental health and mood
Measurements
Odds ratio
1.48 OR
rs237889 A allele, sample 1
Source sentences
Summary
We found nominal over-transmission (OR = 1.48, CI95 = 1.06-2.08, P = 0.022)
1 context sentence(design, population, supporting numbers)
Summary · context
Here, we genotyped and tested two additional variants (rs237889 and rs237897) for association with ASD in two German predominantly high-functioning ASD samples.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-2678892401
03HumanNot a test of Oxytocin aloneObservational studyOther
In German sample 2, the nominal over-transmission of the rs237889 A allele was not found.
In plain wordsIn a second German family sample, the same oxytocin receptor gene variant was not passed on more often to people with autism.
Peptide
Oxytocin
Outcome
No significant changeOXTR rs237889 A allele over-transmission in ASD, sample 2
Study
n: not reported in source
Outcome group
Genetic association · Mental health and mood
Source sentences
Summary
but not in sample 2 (362 trios, 69 duos).
1 context sentence(design, population, supporting numbers)
Summary · context
Here, we genotyped and tested two additional variants (rs237889 and rs237897) for association with ASD in two German predominantly high-functioning ASD samples.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-2678892402
04HumanNot a test of Oxytocin aloneObservational studyOther
Carriers of the rs237889-A risk allele had significantly higher autism severity scores on the ADI-R.
In plain wordsPeople with autism who carry this oxytocin receptor gene variant had higher autism severity scores.
Peptide
Oxytocin
Outcome
IncreaseADI-R severity scores in rs237889-A carriers
Study
n: not reported in source
Outcome group
Genetic association · Mental health and mood
Source sentences
Summary
In addition, carriers of the minor risk allele rs237889-A showed significantly increased severity scores, as assessed through the autism diagnostic interview - revised (ADI-R)
1 context sentence(design, population, supporting numbers)
Summary · context
Here, we genotyped and tested two additional variants (rs237889 and rs237897) for association with ASD in two German predominantly high-functioning ASD samples.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-2678892404
05HumanNot a test of Oxytocin aloneObservational studyOther
Carriers of the rs237889-A risk allele had highly significant increases in social interaction deficits.
In plain wordsPeople with autism who carry this oxytocin receptor gene variant had greater social interaction deficits.
Peptide
Oxytocin
Outcome
IncreaseSocial interaction deficits in rs237889-A carriers
Study
n: not reported in source
Outcome group
Genetic association · Mental health and mood
Source sentences
Summary
with highly significant increases in social interaction deficits.
1 context sentence(design, population, supporting numbers)
Summary · context
Here, we genotyped and tested two additional variants (rs237889 and rs237897) for association with ASD in two German predominantly high-functioning ASD samples.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-2678892405

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
9 Oct 2026, 18:17 UTC
Study results updated
Version 1
9 Oct 2026, 02:50 UTC
First added · source update from Europe PMC

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