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Study · Animal study (in vivo) · 2016

2 results

ARA 290 relieves pathophysiological pain by targeting TRPV1 channel: Integration between immune system and nociception.

Zhang W, Yu G, Zhang M

Peptides13 Jan 2016Cited by 10 (Europe PMC)

PMID26774587 (opens in a new tab)DOI10.1016/j.peptides.2016.01.003 (opens in a new tab)PepBankPUB-26774587
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In behavioral tests, ARA‑290 relieved the mechanical hypersensitivity induced by capsaicin.

    In plain wordsIn behavioral tests, ARA‑290 reduced the mechanical (touch) hypersensitivity caused by capsaicin.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    DecreaseCapsaicin-induced mechanical hypersensitivity
    Study

    n: not reported in source

    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    relieve the mechanical hypersensitivity induced by capsaicin.
    1 context sentence
    Summary · context
    Using calcium imaging, cell culture and behavioral tests, we demonstrated that ARA 290 was able to specifically inhibit TRPV1 channel activity, and relieve the mechanical hypersensitivity induced by capsaicin.
  2. 02LabIn vitro (cells)Mechanism

    In calcium imaging and cell culture experiments, ARA‑290 specifically inhibited TRPV1 channel activity.

    In plain wordsIn cells, ARA‑290 blocked the activity of TRPV1, a pain-sensing channel.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    DecreaseTRPV1 channel activity
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    ARA 290 was able to specifically inhibit TRPV1 channel activity, and relieve the mechanical hypersensitivity induced by capsaicin.
    1 context sentence
    Summary · context
    Using calcium imaging, cell culture and behavioral tests, we demonstrated that ARA 290 was able to specifically inhibit TRPV1 channel activity, and relieve the mechanical hypersensitivity induced by capsaicin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 19:08 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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