Oxytocin modulates behavioral and physiological responses to a stressor in marmoset monkeys.

Cavanaugh J, Carp SB, Rock CM, French JA

Psychoneuroendocrinology30 Dec 2015Cited by 50 (Europe PMC)

PMID26771946PMCIDPMC6007987DOI10.1016/j.psyneuen.2015.12.027PepBankPUB-26771946

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

1 result from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In marmosets exposed to a stressor, augmenting the oxytocin system with Pro(8)-OXT or Leu(8)-OXT did not alter urinary cortisol or proximity behavior.
In plain wordsIn marmoset monkeys under stress, giving extra oxytocin did not change cortisol or how close they stayed to their mate.
Peptide
Oxytocin
Outcome
No significant changeCortisol and proximity behavior with augmented OXT system
Study
common marmoset (Callithrix jacchus)n: not reported in source
social stressor paradigm
Comparator
Saline
Outcome group
Stress hormones · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
We found that blocking, but not augmenting, the OXT system altered patterns of cortisol and proximity behavior in response to a stressor.
1 context sentence(design, population, supporting numbers)
Summary · context
Male and female marmosets experienced a standardized psychogenic stressor with and without their long-term mate under OXT-treatments (Pro(8)-OXT, Leu(8)-OXT, OXT antagonist, and saline); we assessed HPA-axis activity by measuring urinary cortisol across the stressor.
Report a problemFND-2677194601

Studies that did not test the peptide alone2

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

02AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism
In male marmosets exposed to a stressor, an oxytocin antagonist raised HPA-axis activity across the stressor compared with saline.
In plain wordsIn male marmoset monkeys under stress, a drug that blocks oxytocin raised cortisol activity compared with saline.
Peptide
Oxytocin
Outcome
IncreaseUrinary cortisol (HPA-axis activity) with OXT antagonist in males
Study
common marmoset (Callithrix jacchus)n: not reported in source
social stressor paradigm
Comparator
Saline
Outcome group
Stress hormones · Endocrine and hormones
Source sentences
Summary
male, but not female, marmosets treated with an OXT antagonist had significantly higher HPA-axis activity across the stressor than when they were treated with saline, suggesting that the OXT system may reduce the stressor-induced rise in cortisol levels
1 context sentence(design, population, supporting numbers)
Summary · context
Male and female marmosets experienced a standardized psychogenic stressor with and without their long-term mate under OXT-treatments (Pro(8)-OXT, Leu(8)-OXT, OXT antagonist, and saline); we assessed HPA-axis activity by measuring urinary cortisol across the stressor.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-2677194602
03AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism
In male and female marmosets exposed to a stressor, an oxytocin antagonist reduced time in close proximity to the mate during the first 30 min compared with saline.
In plain wordsIn marmoset monkeys under stress, a drug that blocks oxytocin reduced time spent close to their mate compared with saline.
Peptide
Oxytocin
Outcome
DecreaseProximity to mate during the first 30 min of the stressor with OXT antagonist
Study
common marmoset (Callithrix jacchus)n: not reported in source
social stressor paradigm
Comparator
Saline
Outcome group
Social behavior and cognition · Mental health and mood
Source sentences
Summary
male and female marmosets treated with an OXT antagonist spent significantly less time in close proximity to their mate during the first 30 min of the stressor than when they were treated with saline, suggesting that the OXT system may be important for the expression of partner-seeking behavior during a stressor
1 context sentence(design, population, supporting numbers)
Summary · context
Male and female marmosets experienced a standardized psychogenic stressor with and without their long-term mate under OXT-treatments (Pro(8)-OXT, Leu(8)-OXT, OXT antagonist, and saline); we assessed HPA-axis activity by measuring urinary cortisol across the stressor.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-2677194603

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 01:30 UTC
Study results updated
Version 1
9 Oct 2026, 02:50 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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