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Study · Randomized controlled trial · n = 37 · 2016

3 results

Intranasal Oxytocin Normalizes Amygdala Functional Connectivity in Posttraumatic Stress Disorder.

Koch SB, van Zuiden M, Nawijn L, Frijling JL, Veltman DJ, Olff M

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology7 Jan 2016Cited by 116 (Europe PMC)

PMID26741286 (opens in a new tab)PMCIDPMC4908648 (opens in a new tab)DOI10.1038/npp.2016.1 (opens in a new tab)PepBankPUB-26741286
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In patients with PTSD, a single intranasal dose of oxytocin decreased subjective anxiety and nervousness.

    In plain wordsIn people with PTSD, one nasal dose of oxytocin lowered feelings of anxiety and nervousness compared with placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseSubjective anxiety and nervousness
    Study

    n = 37

    Comparator
    Placebo
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    40 IU · intranasal · single doseAs given in this study (human).

    Source sentences

    Summary
    In PTSD patients, OT administration resulted in decreased subjective anxiety and nervousness.
    2 context sentences
    Summary · context
    We therefore investigated the behavioral and neurobiological effects of a single intranasal OT administration (40 IU) in PTSD patients.
    Summary · context
    We conducted a randomized, placebo-controlled, cross-over resting-state fMRI study in male and female police officers with (n=37, 21 males) and without PTSD (n=40, 20 males).
  2. 02HumanRandomized controlled trialMechanism

    In male PTSD patients, intranasal oxytocin reinstated right CeM to left vmPFC connectivity that was diminished under placebo compared with trauma-exposed controls.

    In plain wordsIn men with PTSD, nasal oxytocin restored a weakened link between two brain areas, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseRight CeM to left vmPFC connectivity in male PTSD patients
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    40 IU · intranasal · single doseAs given in this study (human).

    Source sentences

    Summary
    Under placebo, male PTSD patients showed diminished right CeM to left ventromedial prefrontal cortex (vmPFC) connectivity compared with male trauma-exposed controls, which was reinstated after OT administration.
    2 context sentences
    Summary · context
    We therefore investigated the behavioral and neurobiological effects of a single intranasal OT administration (40 IU) in PTSD patients.
    Summary · context
    We conducted a randomized, placebo-controlled, cross-over resting-state fMRI study in male and female police officers with (n=37, 21 males) and without PTSD (n=40, 20 males).
  3. 03HumanRandomized controlled trialMechanism

    In female PTSD patients, intranasal oxytocin dampened the enhanced right BLA to bilateral dACC connectivity seen under placebo compared with trauma-exposed controls.

    In plain wordsIn women with PTSD, nasal oxytocin reduced an overly strong link between two brain areas, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseRight BLA to bilateral dACC connectivity in female PTSD patients
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    40 IU · intranasal · single doseAs given in this study (human).

    Source sentences

    Summary
    Additionally, female PTSD patients showed enhanced right BLA to bilateral dorsal anterior cingulate cortex (dACC) connectivity compared with female trauma-exposed controls, which was dampened after OT administration.
    2 context sentences
    Summary · context
    We therefore investigated the behavioral and neurobiological effects of a single intranasal OT administration (40 IU) in PTSD patients.
    Summary · context
    We conducted a randomized, placebo-controlled, cross-over resting-state fMRI study in male and female police officers with (n=37, 21 males) and without PTSD (n=40, 20 males).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · 1 completed · source ClinicalTrials.gov (opens in a new tab)

CompletedEarly phase 1NCT03211013

Study of the Effects of Oxytocin on Attentional Bias and Startle in PTSD

Palo Alto Veterans Institute for Researchn = 1710 Jul 2017 to 9 Jun 2021

Posttraumatic Stress Disorder

Trial pageClinicalTrials.govUpdated 10 Jun 2021

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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