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Study · Animal study (in vivo) · mouse · 2016

2 results

Signaling, stress response and apoptosis in pre-diabetes and diabetes: restoring immune balance in mice with alloxan-induced type 1 diabetes mellitus.

Novoselova EG, Glushkova OV, Lunin SM, Khrenov MO, Novoselova TV, Parfenyuk SB, Fesenko EE

International immunopharmacology12 Dec 2015Cited by 10 (Europe PMC)

PMID26690976 (opens in a new tab)DOI10.1016/j.intimp.2015.11.007 (opens in a new tab)PepBankPUB-26690976
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In diabetic mice, thymulin improved or normalized immune balance.

    In plain wordsIn mice with diabetes, thymulin improved or normalized immune balance.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    MixedImmune balance in diabetic mice
    Study

    mousen: not reported in source

    Alloxan-induced diabetes
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment with an inhibitor of NF-κB, thymulin, or a diet with an antioxidant improved or normalized the immune balance in diabetic mice and also notably decreased pancreatic cell damage in pre-diabetic mice.
    2 context sentences
    Summary · context
    The aim of this study was to compare immune imbalances in "pre-diabetic" and diabetic mice and to evaluate the efficacy of several agents in improving the immunity of mice with type 1 diabetes.
    Summary · context
    Pre-diabetic and diabetic models generated by a single or double alloxan injection were monitored for plasma glucose and pancreas immunohistochemistry.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In pre-diabetic mice, thymulin notably decreased pancreatic cell damage.

    In plain wordsIn pre-diabetic mice, thymulin reduced pancreatic cell damage.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreasePancreatic cell damage in pre-diabetic mice
    Study

    mousen: not reported in source

    Alloxan-induced diabetes
    Outcome group
    Organ injury · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Treatment with an inhibitor of NF-κB, thymulin, or a diet with an antioxidant improved or normalized the immune balance in diabetic mice and also notably decreased pancreatic cell damage in pre-diabetic mice.
    2 context sentences
    Summary · context
    The aim of this study was to compare immune imbalances in "pre-diabetic" and diabetic mice and to evaluate the efficacy of several agents in improving the immunity of mice with type 1 diabetes.
    Summary · context
    Pre-diabetic and diabetic models generated by a single or double alloxan injection were monitored for plasma glucose and pancreas immunohistochemistry.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:55 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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