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Study · Animal study (in vivo) · mouse · 2016

10 results

A Nonhematopoietic Erythropoietin Analogue, ARA 290, Inhibits Macrophage Activation and Prevents Damage to Transplanted Islets.

Watanabe M, Lundgren T, Saito Y, Cerami A, Brines M, Östenson CG, Kumagai-Braesch M

Transplantation1 Mar 2016Cited by 23 (Europe PMC)

PMID26683514 (opens in a new tab)DOI10.1097/tp.0000000000001026 (opens in a new tab)PepBankPUB-26683514
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In diabetic mice given a marginal islet transplant, ARA‑290 significantly improved blood glucose levels compared with control animals (P < 0.001).

    In plain wordsIn diabetic mice with transplanted islets, ARA‑290 improved blood glucose levels compared with control animals.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    DecreaseBlood glucose after marginal islet transplantation
    Study

    mousen: not reported in source

    marginal pancreatic islet transplantation (185 islets) in streptozotocin-induced diabetic mice
    Comparator
    Control animals
    Outcome group
    Glycemic control · Endocrine and hormones
    Studied dose
    120 μg/kg · intraperitoneal · just before and at 0, 6, and 24 hours after transplantationAs given in this study (mouse).

    Source sentences

    Summary
    After the marginal PITx, ARA 290 treatment significantly improved the blood glucose levels when compared to those of control animals (P < 0.001).
    2 context sentences
    Summary · context
    As a marginal PITx, 185 islets were transplanted into the liver of streptozotocin-induced diabetic mice (H-2) via the portal vein.
    Summary · context
    Recipients were given ARA 290 (120 μg/kg) intraperitoneally just before and at 0, 6, and 24 hours after PITx.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In diabetic mice given an islet transplant, ARA‑290 suppressed the upregulation of monocyte chemoattractant protein-1 mRNA in the liver.

    In plain wordsIn mice with islet transplants, ARA‑290 reduced a rise in the liver inflammation signal MCP-1.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    DecreaseLiver MCP-1 mRNA after islet transplantation
    Study

    mousen: not reported in source

    marginal pancreatic islet transplantation in diabetic mice
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    120 μg/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Upregulation of monocyte chemoattractant protein-1, macrophage inflammatory protein-1β, IL-1β, and IL-6 messenger RNA expression within the liver was suppressed by ARA 290 treatment.
    1 context sentence
    Summary · context
    Liver samples were obtained at 12 hours after PITx, and expression levels of proinflammatory cytokines were assessed.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In diabetic mice given an islet transplant, ARA‑290 suppressed the upregulation of macrophage inflammatory protein-1β mRNA in the liver.

    In plain wordsIn mice with islet transplants, ARA‑290 reduced a rise in the liver inflammation signal MIP-1β.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    DecreaseLiver MIP-1β mRNA after islet transplantation
    Study

    mousen: not reported in source

    marginal pancreatic islet transplantation in diabetic mice
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    120 μg/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Upregulation of monocyte chemoattractant protein-1, macrophage inflammatory protein-1β, IL-1β, and IL-6 messenger RNA expression within the liver was suppressed by ARA 290 treatment.
    1 context sentence
    Summary · context
    Liver samples were obtained at 12 hours after PITx, and expression levels of proinflammatory cytokines were assessed.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In diabetic mice given an islet transplant, ARA‑290 suppressed the upregulation of IL-1β mRNA in the liver.

    In plain wordsIn mice with islet transplants, ARA‑290 reduced a rise in the liver inflammation signal IL-1β.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    DecreaseLiver IL-1β mRNA after islet transplantation
    Study

    mousen: not reported in source

    marginal pancreatic islet transplantation in diabetic mice
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    120 μg/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Upregulation of monocyte chemoattractant protein-1, macrophage inflammatory protein-1β, IL-1β, and IL-6 messenger RNA expression within the liver was suppressed by ARA 290 treatment.
    1 context sentence
    Summary · context
    Liver samples were obtained at 12 hours after PITx, and expression levels of proinflammatory cytokines were assessed.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In diabetic mice given an islet transplant, ARA‑290 suppressed the upregulation of IL-6 mRNA in the liver.

    In plain wordsIn mice with islet transplants, ARA‑290 reduced a rise in the liver inflammation signal IL-6.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    DecreaseLiver IL-6 mRNA after islet transplantation
    Study

    mousen: not reported in source

    marginal pancreatic islet transplantation in diabetic mice
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    120 μg/kg · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Upregulation of monocyte chemoattractant protein-1, macrophage inflammatory protein-1β, IL-1β, and IL-6 messenger RNA expression within the liver was suppressed by ARA 290 treatment.
    1 context sentence
    Summary · context
    Liver samples were obtained at 12 hours after PITx, and expression levels of proinflammatory cytokines were assessed.
  6. 06LabEx vivo tissueEfficacy outcome

    In cultured mouse pancreatic islets, ARA‑290 protected islets from cytokine-induced damage.

    In plain wordsIn lab tests on mouse islets, ARA‑290 protected the islets from damage caused by inflammatory signals.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    DecreaseIslet damage from cytokines
    Study

    mousen: not reported in source

    cultured pancreatic islets
    Outcome group
    Inflammation markers · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    ARA 290 protected islets from cytokine-induced damage and apoptosis.
    1 context sentence
    Summary · context
    The effects of ARA 290 on pancreatic islets of C57BL/6J (H-2) mice and on murine macrophages were investigated using an in vitro culture model.
  7. 07LabEx vivo tissueEfficacy outcome

    In cultured mouse pancreatic islets, ARA‑290 protected islets from cytokine-induced apoptosis.

    In plain wordsIn lab tests on mouse islets, ARA‑290 protected the islets from programmed cell death caused by inflammatory signals.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    DecreaseIslet apoptosis from cytokines
    Study

    mousen: not reported in source

    cultured pancreatic islets
    Outcome group
    Inflammation markers · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    ARA 290 protected islets from cytokine-induced damage and apoptosis.
    1 context sentence
    Summary · context
    The effects of ARA 290 on pancreatic islets of C57BL/6J (H-2) mice and on murine macrophages were investigated using an in vitro culture model.
  8. 08LabIn vitro (cells)Efficacy outcome

    In murine macrophages, ARA‑290 significantly inhibited secretion of IL-6.

    In plain wordsIn mouse immune cells, ARA‑290 lowered release of IL-6, an inflammation signal.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    DecreaseIL-6 secretion from macrophages
    Study

    mousen: not reported in source

    murine macrophages
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Secretion of pro-inflammatory cytokines (IL-6, IL-12, and TNF-α) from macrophages was significantly inhibited by ARA 290.
    1 context sentence
    Summary · context
    The effects of ARA 290 on pancreatic islets of C57BL/6J (H-2) mice and on murine macrophages were investigated using an in vitro culture model.
  9. 09LabIn vitro (cells)Efficacy outcome

    In murine macrophages, ARA‑290 significantly inhibited secretion of IL-12.

    In plain wordsIn mouse immune cells, ARA‑290 lowered release of IL-12, an inflammation signal.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    DecreaseIL-12 secretion from macrophages
    Study

    mousen: not reported in source

    murine macrophages
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Secretion of pro-inflammatory cytokines (IL-6, IL-12, and TNF-α) from macrophages was significantly inhibited by ARA 290.
    1 context sentence
    Summary · context
    The effects of ARA 290 on pancreatic islets of C57BL/6J (H-2) mice and on murine macrophages were investigated using an in vitro culture model.
  10. 10LabIn vitro (cells)Efficacy outcome

    In murine macrophages, ARA‑290 significantly inhibited secretion of TNF-α.

    In plain wordsIn mouse immune cells, ARA‑290 lowered release of TNF-α, an inflammation signal.

    Peptide
    Cibinetide (ARA-290)
    Outcome
    DecreaseTNF-α secretion from macrophages
    Study

    mousen: not reported in source

    murine macrophages
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Secretion of pro-inflammatory cytokines (IL-6, IL-12, and TNF-α) from macrophages was significantly inhibited by ARA 290.
    1 context sentence
    Summary · context
    The effects of ARA 290 on pancreatic islets of C57BL/6J (H-2) mice and on murine macrophages were investigated using an in vitro culture model.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 19:08 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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