Skip to content

Study · Randomized controlled trial · n = 62 · 2016

2 results

Oxytocin improves compassion toward women among patients with PTSD.

Palgi S, Klein E, Shamay-Tsoory SG

Psychoneuroendocrinology17 Nov 2015Cited by 28 (Europe PMC)

PMID26671007 (opens in a new tab)DOI10.1016/j.psyneuen.2015.11.008 (opens in a new tab)PepBankPUB-26671007
Publisher pagePubMedAsk about this study
Jump to 2 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In patients with PTSD and healthy controls, a single intranasal dose of oxytocin enhanced compassion toward women compared with placebo.

    In plain wordsIn people with PTSD and healthy people, one nasal dose of oxytocin raised compassion toward women compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseCompassion toward women
    Study

    n = 62

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    24 IU · intranasal · single doseAs given in this study (human).

    Source sentences

    Summary
    Moreover, the results indicate that a single intranasal dose of OT enhances compassion toward women (but not towards men), both in patients with PTSD and in controls.
    1 context sentence
    Summary · context
    Using a randomized, double-blind, placebo-controlled crossover design, we administered 24 IU of OT and placebo at a one-week interval to 32 patients with PTSD and to 30 matched healthy control participants.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In patients with PTSD and healthy controls, a single intranasal dose of oxytocin did not enhance compassion toward men compared with placebo.

    In plain wordsIn people with PTSD and healthy people, one nasal dose of oxytocin did not raise compassion toward men compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeCompassion toward men
    Study

    n = 62

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    24 IU · intranasal · single doseAs given in this study (human).

    Source sentences

    Summary
    Moreover, the results indicate that a single intranasal dose of OT enhances compassion toward women (but not towards men), both in patients with PTSD and in controls.
    1 context sentence
    Summary · context
    Using a randomized, double-blind, placebo-controlled crossover design, we administered 24 IU of OT and placebo at a one-week interval to 32 patients with PTSD and to 30 matched healthy control participants.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · 1 completed · source ClinicalTrials.gov (opens in a new tab)

CompletedEarly phase 1NCT03211013

Study of the Effects of Oxytocin on Attentional Bias and Startle in PTSD

Palo Alto Veterans Institute for Researchn = 1710 Jul 2017 to 9 Jun 2021

Posttraumatic Stress Disorder

Trial pageClinicalTrials.govUpdated 10 Jun 2021

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.