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Study · Not a test of the peptide alone · 2015

1 result

Ampelopsin protects endothelial cells from hyperglycemia-induced oxidative damage by inducing autophagy via the AMPK signaling pathway.

Liang X, Zhang T, Shi L, Kang C, Wan J, Zhou Y, Zhu J, Mi M

BioFactors (Oxford, England)1 Nov 2015Cited by 31 (Europe PMC)

PMID26644014 (opens in a new tab)DOI10.1002/biof.1248 (opens in a new tab)PepBankPUB-26644014
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone1

In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking AICAR (acadesine).

  1. 01LabNot a test of AICAR (acadesine) aloneIn vitro (cells)Mechanism

    In HUVECs, AICAR strengthened ampelopsin-induced autophagy.

    In plain wordsIn cells, AICAR strengthened the autophagy response to ampelopsin.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseAmpelopsin-induced autophagy
    Study

    humann: not reported in source

    HUVECs
    Outcome group
    Receptor activity and mechanism · Cardiovascular

    Source sentences

    Summary
    Ampelopsin-induced autophagy was attenuated by the AMPK antagonist compound C but strengthened by the AMPK agonist AICAR (5-minoimidazole-4-carboxamide ribonucleotide).
    1 context sentence
    Summary · context
    This study focused on the effect of ampelopsin on hyperglycemia-induced oxidative damage and the underlying mechanism of this effect in human umbilical vein endothelial cells (HUVECs).

    In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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