The role of mechano-growth factor E peptide in the regulation of osteosarcoma.

Shang J, Fan X, Liu H

Oncology letters9 Jun 2015Cited by 6 (Europe PMC)

PMID26622556PMCIDPMC4509376DOI10.3892/ol.2015.3339PepBankPUB-26622556

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

4 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Mechanism
In osteosarcoma cell lines, MGF-E treatment altered the cell cycle distribution.
In plain wordsIn lab cell lines, MGF-E peptide changed how bone cancer cells were spread across the cell cycle.
Peptide
MGF / PEG-MGF
Outcome
Direction not reportedCell cycle distribution
Study
n: not reported in source
osteosarcoma cell lines
Outcome group
Tumor growth · Cancer
Studied dose
Dose not stated
Source sentences
Summary
Furthermore, MGF-E treatment altered the cell cycle distribution, and promoted the proliferation, migration and invasion of osteosarcoma cells.
1 context sentence(design, population, supporting numbers)
Summary · context
Concomitantly, exogenous MGF-E peptide was used to stimulate these osteosarcoma cell lines.
Report a problemFND-2662255603
02LabIn vitro (cells)Efficacy outcome
In osteosarcoma cell lines, MGF-E treatment promoted proliferation.
In plain wordsIn lab cell lines, MGF-E peptide made bone cancer cells grow more.
Peptide
MGF / PEG-MGF
Outcome
IncreaseProliferation of osteosarcoma cells
Study
n: not reported in source
osteosarcoma cell lines
Outcome group
Tumor growth · Cancer
Studied dose
Dose not stated
Source sentences
Summary
Furthermore, MGF-E treatment altered the cell cycle distribution, and promoted the proliferation, migration and invasion of osteosarcoma cells.
1 context sentence(design, population, supporting numbers)
Summary · context
Concomitantly, exogenous MGF-E peptide was used to stimulate these osteosarcoma cell lines.
Report a problemFND-2662255604
03LabIn vitro (cells)Efficacy outcome
In osteosarcoma cell lines, MGF-E treatment promoted migration.
In plain wordsIn lab cell lines, MGF-E peptide made bone cancer cells move more.
Peptide
MGF / PEG-MGF
Outcome
IncreaseMigration of osteosarcoma cells
Study
n: not reported in source
osteosarcoma cell lines
Outcome group
Tumor growth · Cancer
Studied dose
Dose not stated
Source sentences
Summary
Furthermore, MGF-E treatment altered the cell cycle distribution, and promoted the proliferation, migration and invasion of osteosarcoma cells.
1 context sentence(design, population, supporting numbers)
Summary · context
Concomitantly, exogenous MGF-E peptide was used to stimulate these osteosarcoma cell lines.
Report a problemFND-2662255605
04LabIn vitro (cells)Efficacy outcome
In osteosarcoma cell lines, MGF-E treatment promoted invasion.
In plain wordsIn lab cell lines, MGF-E peptide made bone cancer cells invade more.
Peptide
MGF / PEG-MGF
Outcome
IncreaseInvasion of osteosarcoma cells
Study
n: not reported in source
osteosarcoma cell lines
Outcome group
Tumor growth · Cancer
Studied dose
Dose not stated
Source sentences
Summary
Furthermore, MGF-E treatment altered the cell cycle distribution, and promoted the proliferation, migration and invasion of osteosarcoma cells.
1 context sentence(design, population, supporting numbers)
Summary · context
Concomitantly, exogenous MGF-E peptide was used to stimulate these osteosarcoma cell lines.
Report a problemFND-2662255606

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

05LabEndogenous levelIn vitro (cells)Other
In osteosarcoma cell lines, natural MGF was overexpressed in malignant osteosarcoma cells.
In plain wordsIn lab cell lines, the body's own MGF was higher in aggressive bone cancer cells.
Peptide
MGF / PEG-MGF
Outcome
IncreaseMGF expression in malignant osteosarcoma cells
Study
n: not reported in source
osteosarcoma cell lines
Outcome group
Tumor growth · Cancer
Source sentences
Summary
MGF was overexpressed in malignant osteosarcoma cells,
1 context sentence(design, population, supporting numbers)
Summary · context
In order to investigate the effects of the mechano-growth factor E (MGF-E) peptide, which is derived from the IGF-I alternative splicing isoform, on the regulation of the development of osteosarcoma, the expression of MGF was detected in osteosarcoma cell lines with different degrees of malignancy.
This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2662255601
06LabEndogenous levelIn vitro (cells)Other
In osteosarcoma cell lines, natural MGF was not expressed in the least malignant osteosarcoma cells.
In plain wordsIn lab cell lines, the body's own MGF was absent in the least aggressive bone cancer cells.
Peptide
MGF / PEG-MGF
Outcome
Not applicableMGF expression in the least malignant osteosarcoma cells
Study
n: not reported in source
osteosarcoma cell lines
Outcome group
Tumor growth · Cancer
Source sentences
Summary
while it was not expressed in the least malignant osteosarcoma cells.
1 context sentence(design, population, supporting numbers)
Summary · context
In order to investigate the effects of the mechano-growth factor E (MGF-E) peptide, which is derived from the IGF-I alternative splicing isoform, on the regulation of the development of osteosarcoma, the expression of MGF was detected in osteosarcoma cell lines with different degrees of malignancy.
This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-2662255602

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Keywords

PepBank is a research reference. Talk to a doctor before you use any peptide.