Skip to content

Study · Animal study (in vivo) · rat · 2015

6 results

[THE EFFECT OF ACTH-(4-7)-PGP PEPTIDE ON LIPID PEROXIDATION IN LIVER AND ACTIVITY OF SERUM TRANSAMINASES IN RATS UNDER ACUTE AND CHRONIC IMMOBILIZATION STRESS CONDITIONS].

Bobyntsev I, Kryukov AA, Shepeleva M, Ivanov AV

Eksperimental'naia i klinicheskaia farmakologiia1 Jan 2015

PMID26591577 (opens in a new tab)PepBankPUB-26591577
Publisher pageAsk about this study
Jump to 6 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats under immobilization stress, Semax across the whole studied dose range produced an antioxidant effect in hepatocytes.

    In plain wordsIn rats under stress, Semax at all tested doses had an antioxidant effect in liver cells.

    Peptide
    Semax
    Outcome
    DecreaseHepatocyte free-radical oxidation (antioxidant effect)
    Study

    ratn: not reported in source

    Wistar male rats, acute and chronic immobilization stress
    Outcome group
    Oxidative stress · Liver
    Studied dose
    5, 50, 150 and 450 μg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    peptide administration in the entire dose range studied produced antioxidant effect in hepatocytes
    1 context sentence
    Summary · context
    The effect of ACTH-(4-7)-PGP (semax) intraperitoneal injection at doses of 5, 50, 150 and 450 μg/kg b.w. on the free-radical oxidation and the activity of serum transaminases in Wistar male rats subjected to acute and chronic immobilization stress has been studied.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats under acute immobilization stress, Semax at 150 mg/kg (as written) produced prooxidant effects.

    In plain wordsIn rats under short-term stress, Semax at one dose had a prooxidant effect, the opposite of an antioxidant effect.

    Peptide
    Semax
    Outcome
    IncreaseHepatocyte free-radical oxidation under acute stress (prooxidant effect)
    Study

    ratn: not reported in source

    Wistar male rats, acute and chronic immobilization stress
    Outcome group
    Oxidative stress · Liver
    Studied dose
    150 mg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    prooxidant effects were observed at a drug dose of 150 mg/kg under acute stress conditions
    1 context sentence
    Summary · context
    The effect of ACTH-(4-7)-PGP (semax) intraperitoneal injection at doses of 5, 50, 150 and 450 μg/kg b.w. on the free-radical oxidation and the activity of serum transaminases in Wistar male rats subjected to acute and chronic immobilization stress has been studied.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats under chronic immobilization stress, Semax at 450 μg/kg significantly increased serum ALT activity.

    In plain wordsIn rats under long-term stress, Semax at 450 μg/kg raised the blood liver enzyme ALT.

    Peptide
    Semax
    Outcome
    IncreaseSerum ALT activity at 450 μg/kg in chronic stress
    Study

    ratn: not reported in source

    Wistar male rats, acute and chronic immobilization stress
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    450 μg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    significantly increased the activity of serum ALT and AST at a dose of 450 μg/kg under chronic stress conditions.
    1 context sentence
    Summary · context
    The effect of ACTH-(4-7)-PGP (semax) intraperitoneal injection at doses of 5, 50, 150 and 450 μg/kg b.w. on the free-radical oxidation and the activity of serum transaminases in Wistar male rats subjected to acute and chronic immobilization stress has been studied.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats under chronic immobilization stress, Semax at 450 μg/kg significantly increased serum AST activity.

    In plain wordsIn rats under long-term stress, Semax at 450 μg/kg raised the blood liver enzyme AST.

    Peptide
    Semax
    Outcome
    IncreaseSerum AST activity at 450 μg/kg in chronic stress
    Study

    ratn: not reported in source

    Wistar male rats, acute and chronic immobilization stress
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    450 μg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    significantly increased the activity of serum ALT and AST at a dose of 450 μg/kg under chronic stress conditions.
    1 context sentence
    Summary · context
    The effect of ACTH-(4-7)-PGP (semax) intraperitoneal injection at doses of 5, 50, 150 and 450 μg/kg b.w. on the free-radical oxidation and the activity of serum transaminases in Wistar male rats subjected to acute and chronic immobilization stress has been studied.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats under immobilization stress, Semax at 5 and 50 μg/kg decreased serum ALT activity.

    In plain wordsIn rats under stress, Semax at 5 and 50 μg/kg lowered the blood liver enzyme ALT.

    Peptide
    Semax
    Outcome
    DecreaseSerum ALT activity at 5 and 50 μg/kg
    Study

    ratn: not reported in source

    Wistar male rats, acute and chronic immobilization stress
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    5 and 50 μg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    The ALT activity was decreased at doses of 5 and 50 μg/kg, but increased at a dose of 450 μg/kg.
    1 context sentence
    Summary · context
    The effect of ACTH-(4-7)-PGP (semax) intraperitoneal injection at doses of 5, 50, 150 and 450 μg/kg b.w. on the free-radical oxidation and the activity of serum transaminases in Wistar male rats subjected to acute and chronic immobilization stress has been studied.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats under immobilization stress, Semax at 5 μg/kg reliably increased serum AST activity.

    In plain wordsIn rats under stress, Semax at 5 μg/kg raised the blood liver enzyme AST.

    Peptide
    Semax
    Outcome
    IncreaseSerum AST activity at 5 μg/kg
    Study

    ratn: not reported in source

    Wistar male rats, acute and chronic immobilization stress
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    5 μg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    The AST activity was already reliably increased at a dose of 5 μg/kg.
    1 context sentence
    Summary · context
    The effect of ACTH-(4-7)-PGP (semax) intraperitoneal injection at doses of 5, 50, 150 and 450 μg/kg b.w. on the free-radical oxidation and the activity of serum transaminases in Wistar male rats subjected to acute and chronic immobilization stress has been studied.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.