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Study · Not a test of the peptide alone · 2014

3 results

Enhanced delivery of hydrophilic peptides in vitro by transdermal microneedle pretreatment.

Zhang S, Qiu Y, Gao Y

Acta pharmaceutica Sinica. B24 Jan 2014Cited by 48 (Europe PMC)

PMID26579370 (opens in a new tab)PMCIDPMC4590292 (opens in a new tab)DOI10.1016/j.apsb.2013.12.011 (opens in a new tab)PepBankPUB-26579370
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, the peptide was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking the peptide.

  1. 01LabNot a test of Argireline (acetyl hexapeptide-8) aloneEx vivo tissuePharmacokinetics

    In porcine ear skin, microneedle pretreatment enhanced permeation of the peptide pool containing acetyl hexapeptide-3, with molecular-weight-dependent rates.

    In plain wordsIn lab tests on pig skin, microneedle pretreatment increased permeation of pooled peptides, including acetyl hexapeptide-3, versus no pretreatment.

    Peptide
    Argireline (acetyl hexapeptide-8)
    Outcome
    IncreasePooled peptide permeation after microneedle pretreatment
    Study

    pign: not reported in source

    Porcine ear skin
    Comparator
    Without microneedle pretreatment
    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    Peptide permeation across the skin was significantly enhanced by microneedle pretreatment, and permeation rates were dependent on peptide molecular weights.
    2 context sentences
    Summary · context
    Four model peptides were used (Gly-Gln-Pro-Arg [tetrapeptide-3, 456.6 Da], Val-Gly-Val-Ala-Pro-Gly [hexapeptide, 498.6 Da], AC-Glu-Glu-Met-Gln-Arg-Arg-NH2 [acetyl hexapeptide-3, 889 Da] and Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2 [oxytocin, 1007.2 Da]).
    Summary · context
    The influence of microneedle pretreatment on skin permeation was evaluated using porcine ear skin with Franze diffusion cell.

    In this study, Argireline (acetyl hexapeptide-8) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Argireline (acetyl hexapeptide-8).

  2. 02LabNot a test of Oxytocin aloneEx vivo tissuePharmacokinetics

    In porcine ear skin, microneedle pretreatment enhanced permeation of the peptide pool containing oxytocin, with molecular-weight-dependent rates.

    In plain wordsIn lab tests on pig skin, microneedle pretreatment increased permeation of pooled peptides, including oxytocin, versus no pretreatment.

    Peptide
    Oxytocin
    Outcome
    IncreasePooled peptide permeation after microneedle pretreatment
    Study

    pign: not reported in source

    Porcine ear skin
    Comparator
    Without microneedle pretreatment
    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    Peptide permeation across the skin was significantly enhanced by microneedle pretreatment, and permeation rates were dependent on peptide molecular weights.
    2 context sentences
    Summary · context
    Four model peptides were used (Gly-Gln-Pro-Arg [tetrapeptide-3, 456.6 Da], Val-Gly-Val-Ala-Pro-Gly [hexapeptide, 498.6 Da], AC-Glu-Glu-Met-Gln-Arg-Arg-NH2 [acetyl hexapeptide-3, 889 Da] and Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2 [oxytocin, 1007.2 Da]).
    Summary · context
    The influence of microneedle pretreatment on skin permeation was evaluated using porcine ear skin with Franze diffusion cell.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  3. 03LabNot a test of Argireline (acetyl hexapeptide-8) aloneEx vivo tissueMechanism

    In porcine ear skin, D2O flux correlated positively with acetyl hexapeptide-3 clearance, suggesting a contribution from convective solvent flow.

    In plain wordsIn lab tests on pig skin, higher D2O flux was linked to higher acetyl hexapeptide-3 clearance.

    Peptide
    Argireline (acetyl hexapeptide-8)
    Outcome
    IncreaseD2O flux and acetyl hexapeptide-3 clearance correlation
    Study

    pign: not reported in source

    Porcine ear skin
    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    A positive correlation between D2O flux and acetyl hexapeptide-3 clearances suggests that convective solvent flow contributes to the enhanced transdermal peptide delivery.
    2 context sentences
    Summary · context
    Four model peptides were used (Gly-Gln-Pro-Arg [tetrapeptide-3, 456.6 Da], Val-Gly-Val-Ala-Pro-Gly [hexapeptide, 498.6 Da], AC-Glu-Glu-Met-Gln-Arg-Arg-NH2 [acetyl hexapeptide-3, 889 Da] and Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2 [oxytocin, 1007.2 Da]).
    Summary · context
    The influence of microneedle pretreatment on skin permeation was evaluated using porcine ear skin with Franze diffusion cell.

    In this study, Argireline (acetyl hexapeptide-8) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Argireline (acetyl hexapeptide-8).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    22 Oct 2026, 02:25 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 18:59 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:51 UTC

    First added · source update from Europe PMC

Subjects

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