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Study · In vitro (cells) · 2015

10 results

[EFFECT OF PEPTIDE SEMAX ON SYNAPTIC ACTIVITY AND SHORT-TERM PLASTICITY OF GLUTAMATERGIC SYNAPSES OF CO-CULTURED DORSAL ROOT GANGLION AND DORSAL HORN NEURONS].

Shypshyna MS, Veselovsky NS, Myasoedov NF, Shram SI, Fedulova SA

Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994)1 Jan 2015Cited by 2 (Europe PMC)

PMID26552305 (opens in a new tab)DOI10.15407/fz61.04.048 (opens in a new tab)PepBankPUB-26552305
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In co-cultured dorsal root ganglion and dorsal horn neurons, 100 µM Semax increased the paired-pulse ratio in sensory synapses from 0.53 to 0.95 (P < 0.001).

    In plain wordsIn cultured nerve cells, Semax at 100 µM changed short-term signal behaviour by raising the paired-pulse ratio.

    Peptide
    Semax
    Outcome
    IncreasePaired-pulse ratio
    Study

    n = 7

    Co-cultured dorsal root ganglion and dorsal horn neurons
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    100 µM · 12 days in vitroAs given in this study.

    Measurements

    Paired-pulse ratio
    0.95 ratio
    100 µM Semax
    Paired-pulse ratio
    0.53 ratio
    baseline

    Source sentences

    Summary
    increasing the paired-pulse ratio from 0.53 ± 0.028 (n = 8) to 0.91 ± 0.072 (n = 6, P < 0.01) and 0.95 ± 0.026 (n = 7; P < 0.001)
    1 context sentence
    Summary · context
    The influence of long-term culturing (12 days in vitro) of dorsal root ganglion (DRG) and dorsal horn (DH) neurons with peptide Semax on the level of synaptic activity at co-cultures, as well as short-term plasticity in sensory synapses were studied.
  2. 02LabIn vitro (cells)Activity measurement

    In co-cultured dorsal root ganglion and dorsal horn neurons, 100 µM Semax reduced the CV2/CV1 ratio from 1.49 to 1.11.

    In plain wordsIn cultured nerve cells, Semax at 100 µM lowered the CV2/CV1 ratio, a measure of synaptic transmission.

    Peptide
    Semax
    Outcome
    DecreaseRatio of coefficients of variation (CV2/CV1)
    Study

    n = 7

    Co-cultured dorsal root ganglion and dorsal horn neurons
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    100 µM · 12 days in vitroAs given in this study.

    Measurements

    CV2/CV1
    1.11 ratio
    100 µM Semax
    CV2/CV1
    1.49 ratio
    baseline

    Source sentences

    Summary
    reducing the ratio of the coefficients of variation (CV2/ CV1) from 1.49 ± 0.11 (n = 8) to 1.02 ± 0.09 (n = 6; P < 0.05) and 1.11 ± 0.13 (n = 7; P < 0.0)
    1 context sentence
    Summary · context
    The influence of long-term culturing (12 days in vitro) of dorsal root ganglion (DRG) and dorsal horn (DH) neurons with peptide Semax on the level of synaptic activity at co-cultures, as well as short-term plasticity in sensory synapses were studied.
  3. 03LabIn vitro (cells)Activity measurement

    In co-cultured dorsal root ganglion and dorsal horn neurons, 10 µM Semax increased the frequency of spontaneous glutamatergic postsynaptic currents in dorsal horn neurons (to 71.7 ± 1.8%, P < 0.001).

    In plain wordsIn cultured nerve cells, Semax at 10 µM made spontaneous glutamate signals in dorsal horn neurons more frequent.

    Peptide
    Semax
    Outcome
    IncreaseFrequency of spontaneous glutamatergic postsynaptic currents in DH neurons
    Study

    n = 6

    Co-cultured dorsal root ganglion and dorsal horn neurons
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    10 µM · 12 days in vitroAs given in this study.

    Measurements

    Spontaneous glutamatergic current frequency
    71.7%
    10 µM Semax

    Source sentences

    Summary
    neuronal culturing with peptide at concentrations of 10 and 100 µM led to increasing the frequency of spontaneous glutamatergic postsynaptic currents in DH neurons to 71.7 ± 1.8% and 93.9 ± 3.1% (n = 6; P < 0.001)
    1 context sentence
    Summary · context
    The influence of long-term culturing (12 days in vitro) of dorsal root ganglion (DRG) and dorsal horn (DH) neurons with peptide Semax on the level of synaptic activity at co-cultures, as well as short-term plasticity in sensory synapses were studied.
  4. 04LabIn vitro (cells)Activity measurement

    In co-cultured dorsal root ganglion and dorsal horn neurons, 100 µM Semax increased the frequency of spontaneous glutamatergic postsynaptic currents in dorsal horn neurons (to 93.9 ± 3.1%, P < 0.001).

    In plain wordsIn cultured nerve cells, Semax at 100 µM made spontaneous glutamate signals in dorsal horn neurons more frequent.

    Peptide
    Semax
    Outcome
    IncreaseFrequency of spontaneous glutamatergic postsynaptic currents in DH neurons
    Study

    n = 6

    Co-cultured dorsal root ganglion and dorsal horn neurons
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    100 µM · 12 days in vitroAs given in this study.

    Measurements

    Spontaneous glutamatergic current frequency
    93.9%
    100 µM Semax

    Source sentences

    Summary
    neuronal culturing with peptide at concentrations of 10 and 100 µM led to increasing the frequency of spontaneous glutamatergic postsynaptic currents in DH neurons to 71.7 ± 1.8% and 93.9 ± 3.1% (n = 6; P < 0.001)
    1 context sentence
    Summary · context
    The influence of long-term culturing (12 days in vitro) of dorsal root ganglion (DRG) and dorsal horn (DH) neurons with peptide Semax on the level of synaptic activity at co-cultures, as well as short-term plasticity in sensory synapses were studied.
  5. 05LabIn vitro (cells)Activity measurement

    In co-cultured dorsal root ganglion and dorsal horn neurons, 10 µM Semax increased the paired-pulse ratio in sensory synapses from 0.53 to 0.91 (P < 0.01).

    In plain wordsIn cultured nerve cells, Semax at 10 µM changed short-term signal behaviour by raising the paired-pulse ratio.

    Peptide
    Semax
    Outcome
    IncreasePaired-pulse ratio
    Study

    n = 6

    Co-cultured dorsal root ganglion and dorsal horn neurons
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    10 µM · 12 days in vitroAs given in this study.

    Measurements

    Paired-pulse ratio
    0.91 ratio
    10 µM Semax
    Paired-pulse ratio
    0.53 ratio
    baseline

    Source sentences

    Summary
    increasing the paired-pulse ratio from 0.53 ± 0.028 (n = 8) to 0.91 ± 0.072 (n = 6, P < 0.01) and 0.95 ± 0.026 (n = 7; P < 0.001)
    1 context sentence
    Summary · context
    The influence of long-term culturing (12 days in vitro) of dorsal root ganglion (DRG) and dorsal horn (DH) neurons with peptide Semax on the level of synaptic activity at co-cultures, as well as short-term plasticity in sensory synapses were studied.
  6. 06LabIn vitro (cells)Activity measurement

    In co-cultured dorsal root ganglion and dorsal horn neurons, 10 µM Semax reduced the CV2/CV1 ratio from 1.49 to 1.02 (P < 0.05).

    In plain wordsIn cultured nerve cells, Semax at 10 µM lowered the CV2/CV1 ratio, a measure of synaptic transmission.

    Peptide
    Semax
    Outcome
    DecreaseRatio of coefficients of variation (CV2/CV1)
    Study

    n = 6

    Co-cultured dorsal root ganglion and dorsal horn neurons
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    10 µM · 12 days in vitroAs given in this study.

    Measurements

    CV2/CV1
    1.02 ratio
    10 µM Semax
    CV2/CV1
    1.49 ratio
    baseline

    Source sentences

    Summary
    reducing the ratio of the coefficients of variation (CV2/ CV1) from 1.49 ± 0.11 (n = 8) to 1.02 ± 0.09 (n = 6; P < 0.05) and 1.11 ± 0.13 (n = 7; P < 0.0)
    1 context sentence
    Summary · context
    The influence of long-term culturing (12 days in vitro) of dorsal root ganglion (DRG) and dorsal horn (DH) neurons with peptide Semax on the level of synaptic activity at co-cultures, as well as short-term plasticity in sensory synapses were studied.
  7. 07LabIn vitro (cells)Activity measurement

    In co-cultured dorsal root ganglion and dorsal horn neurons, Semax had no significant effect on the amplitude of miniature glutamatergic currents.

    In plain wordsIn cultured nerve cells, Semax did not significantly change the size of miniature glutamate signals.

    Peptide
    Semax
    Outcome
    No significant changeAmplitude of miniature glutamatergic currents
    Study

    n: not reported in source

    Co-cultured dorsal root ganglion and dorsal horn neurons
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    10 and 100 µM · 12 days in vitroAs given in this study.

    Source sentences

    Summary
    Semax has a not significant effect on the amplitude and frequency of miniature glutamatergic currents
    1 context sentence
    Summary · context
    The influence of long-term culturing (12 days in vitro) of dorsal root ganglion (DRG) and dorsal horn (DH) neurons with peptide Semax on the level of synaptic activity at co-cultures, as well as short-term plasticity in sensory synapses were studied.
  8. 08LabIn vitro (cells)Activity measurement

    In co-cultured dorsal root ganglion and dorsal horn neurons, Semax had no significant effect on the frequency of miniature glutamatergic currents.

    In plain wordsIn cultured nerve cells, Semax did not significantly change how often miniature glutamate signals occurred.

    Peptide
    Semax
    Outcome
    No significant changeFrequency of miniature glutamatergic currents
    Study

    n: not reported in source

    Co-cultured dorsal root ganglion and dorsal horn neurons
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    10 and 100 µM · 12 days in vitroAs given in this study.

    Source sentences

    Summary
    Semax has a not significant effect on the amplitude and frequency of miniature glutamatergic currents
    1 context sentence
    Summary · context
    The influence of long-term culturing (12 days in vitro) of dorsal root ganglion (DRG) and dorsal horn (DH) neurons with peptide Semax on the level of synaptic activity at co-cultures, as well as short-term plasticity in sensory synapses were studied.
  9. 09LabIn vitro (cells)Activity measurement

    In co-cultured dorsal root ganglion and dorsal horn neurons, Semax increased the amplitudes of spontaneous postsynaptic currents.

    In plain wordsIn cultured nerve cells, Semax increased the size of spontaneous nerve signals.

    Peptide
    Semax
    Outcome
    IncreaseAmplitude of spontaneous postsynaptic currents
    Study

    n: not reported in source

    Co-cultured dorsal root ganglion and dorsal horn neurons
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    10 and 100 µM · 12 days in vitroAs given in this study.

    Source sentences

    Summary
    but causes an increase of the amplitudes of spontaneous postsynaptic currents, as well as elevates the quantum content.
    1 context sentence
    Summary · context
    The influence of long-term culturing (12 days in vitro) of dorsal root ganglion (DRG) and dorsal horn (DH) neurons with peptide Semax on the level of synaptic activity at co-cultures, as well as short-term plasticity in sensory synapses were studied.
  10. 10LabIn vitro (cells)Activity measurement

    In co-cultured dorsal root ganglion and dorsal horn neurons, Semax elevated the quantum content of synaptic transmission.

    In plain wordsIn cultured nerve cells, Semax raised the quantum content, a measure of how much signal is released at synapses.

    Peptide
    Semax
    Outcome
    IncreaseQuantum content
    Study

    n: not reported in source

    Co-cultured dorsal root ganglion and dorsal horn neurons
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    10 and 100 µM · 12 days in vitroAs given in this study.

    Source sentences

    Summary
    but causes an increase of the amplitudes of spontaneous postsynaptic currents, as well as elevates the quantum content.
    1 context sentence
    Summary · context
    The influence of long-term culturing (12 days in vitro) of dorsal root ganglion (DRG) and dorsal horn (DH) neurons with peptide Semax on the level of synaptic activity at co-cultures, as well as short-term plasticity in sensory synapses were studied.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

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