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Study · Measured the body's own peptide · 2015

2 results

Nasal Levels of Antimicrobial Peptides in Allergic Asthma Patients and Healthy Controls: Differences and Effect of a Short 1,25(OH)2 Vitamin D3 Treatment.

Thijs W, Janssen K, van Schadewijk AM, Papapoulos SE, le Cessie S, Middeldorp S, Melissant CF, Rabe KF, Hiemstra PS

PloS one6 Nov 2015Cited by 18 (Europe PMC)

PMID26545199 (opens in a new tab)PMCIDPMC4636236 (opens in a new tab)DOI10.1371/journal.pone.0140986 (opens in a new tab)PepBankPUB-26545199
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Summary

BackgroundAllergy is often accompanied by infections and lower levels of antimicrobial peptides (AMPs). Vitamin D has been shown to increase expression of selected AMPs. In this study we investigated whether antimicrobial peptide levels in nasal secretions of allergic asthma patients are lower than in healthy controls, and whether administration of the active form of vitamin D (1,25(OH)2D3) affects these antimicrobial peptide levels.MethodsThe levels of antimicrobial peptides in nasal secretions were compared between 19 allergic asthma patients and 23 healthy controls. The effect of seven days daily oral treatment with 2 μg 1,25(OH)2D3 on antimicrobial peptides in nasal secretions was assessed in a placebo-controlled cross-over clinical study.ResultsLevels of neutrophil α-defensins (human neutrophil peptides 1-3; HNP1-3) and lipocalin 2 (LCN2; also known as NGAL) were significantly lower in asthmatics, but no differences in LL-37 and SLPI were detected. Treatment with a short-term 1,25(OH)2D3 caused a small increase in HNP1-3, but not when the asthma and control groups were analyzed separately. LL-37, LCN2 and SLPI did not change after treatment with 1,25(OH)2D3.ConclusionLevels of the antimicrobial peptides HNP1-3 and LCN2 are lower in nasal secretions in asthmatics and are not substantially affected by a short-term treatment with active vitamin D.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study2

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelRandomized controlled trialOther

    Seven days of oral 1,25(OH)2D3 did not change the level of the body's own LL‑37 in nasal secretions in a placebo-controlled cross-over study.

    In plain wordsA short course of active vitamin D did not change the body's own LL‑37 in nasal fluid.

    Peptide
    LL-37
    Outcome
    No significant changeNasal LL-37 after 1,25(OH)2D3 treatment
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Immune response · Respiratory

    Source sentences

    Summary
    LL-37, LCN2 and SLPI did not change after treatment with 1,25(OH)2D3.
    2 context sentences
    Summary · context
    The levels of antimicrobial peptides in nasal secretions were compared between 19 allergic asthma patients and 23 healthy controls.
    Summary · context
    The effect of seven days daily oral treatment with 2 μg 1,25(OH)2D3 on antimicrobial peptides in nasal secretions was assessed in a placebo-controlled cross-over clinical study.

    This result measures the body's own LL-37. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelObservational studyOther

    Levels of the body's own LL‑37 in nasal secretions did not differ between 19 allergic asthma patients and 23 healthy controls.

    In plain wordsNatural LL‑37 levels in nasal fluid were similar in people with allergic asthma and healthy people.

    Peptide
    LL-37
    Outcome
    No significant changeNasal LL-37 in allergic asthma patients versus healthy controls
    Study

    n = 42

    Comparator
    Healthy controls
    Outcome group
    Immune response · Respiratory

    Source sentences

    Summary
    Levels of neutrophil α-defensins (human neutrophil peptides 1-3; HNP1-3) and lipocalin 2 (LCN2; also known as NGAL) were significantly lower in asthmatics, but no differences in LL-37 and SLPI were detected.
    2 context sentences
    Summary · context
    The levels of antimicrobial peptides in nasal secretions were compared between 19 allergic asthma patients and 23 healthy controls.
    Summary · context
    The effect of seven days daily oral treatment with 2 μg 1,25(OH)2D3 on antimicrobial peptides in nasal secretions was assessed in a placebo-controlled cross-over clinical study.

    This result measures the body's own LL-37. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:57 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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