Enhancement of Lumbar Fusion and Alleviation of Adjacent Segment Disc Degeneration by Intermittent PTH(1-34) in Ovariectomized Rats.

Zhou Z, Tian FM, Gou Y, Wang P, Zhang H, Song HP, Shen Y, Zhang YZ, Zhang L

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research27 Nov 2015Cited by 28 (Europe PMC)

PMID26542457DOI10.1002/jbmr.2736PepBankPUB-26542457

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In ovariectomized rats, PTH increased new bone formation versus controls.
In plain wordsIn rats, PTH increased new bone formation versus controls.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseNew bone formation
Study
ratn: not reported in source
Ovariectomized lumbar fusion model
Comparator
control group
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · 8 weeksAs given in this study (rat).
Source sentences
Summary
Greater new bone formation in histology was observed in PTH-treated animals compared to the control group.
2 context sentences(design, population, supporting numbers)
Summary · context
In the present study, we evaluated the effects of intermittent PTH(1-34) on ASDD in an ovariectomized (OVX) rat model.
Summary · context
PTH(1-34) was intermittently administered immediately after PLF surgery and lasted for 8 weeks using the following groups (n = 20) (V = vehicle): Sham+V, OVX+V, Sham+PLF+V, OVX+PLF+V, OVX+PLF+PTH.
Report a problemFND-2654245701
02AnimalAnimal study (in vivo)Efficacy outcome
In ovariectomized rats, intermittent PTH alleviated adjacent segment disc degeneration while preserving disc and endplate features.
In plain wordsIn rats, intermittent PTH reduced adjacent disc degeneration while preserving disc and endplate features.
Peptide
Teriparatide (PTH 1-34)
Outcome
DecreaseAdjacent segment disc degeneration
Study
ratn: not reported in source
Ovariectomized lumbar fusion model
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · 8 weeksAs given in this study (rat).
Source sentences
Summary
Intermittent PTH(1-34) significantly alleviated ASDD by preserving disc height, microvessel density, relative area of vascular buds, endplate thickness and the relative area of endplate calcification.
2 context sentences(design, population, supporting numbers)
Summary · context
In the present study, we evaluated the effects of intermittent PTH(1-34) on ASDD in an ovariectomized (OVX) rat model.
Summary · context
PTH(1-34) was intermittently administered immediately after PLF surgery and lasted for 8 weeks using the following groups (n = 20) (V = vehicle): Sham+V, OVX+V, Sham+PLF+V, OVX+PLF+V, OVX+PLF+PTH.
Report a problemFND-2654245702
03AnimalAnimal study (in vivo)Mechanism
In ovariectomized rats, PTH decreased MMP-13 expression.
In plain wordsIn rats, PTH decreased MMP-13 expression.
Peptide
Teriparatide (PTH 1-34)
Outcome
DecreaseMMP-13 expression
Study
ratn: not reported in source
Ovariectomized lumbar fusion model
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · 8 weeksAs given in this study (rat).
Source sentences
Summary
Moreover, protein expression results showed that PTH(1-34) not only inhibited matrix degradation by decreasing MMP-13, ADAMTS-4 and Col-I, but also promote matrix synthesis by increasing Col-II and Aggrecan.
2 context sentences(design, population, supporting numbers)
Summary · context
In the present study, we evaluated the effects of intermittent PTH(1-34) on ASDD in an ovariectomized (OVX) rat model.
Summary · context
PTH(1-34) was intermittently administered immediately after PLF surgery and lasted for 8 weeks using the following groups (n = 20) (V = vehicle): Sham+V, OVX+V, Sham+PLF+V, OVX+PLF+V, OVX+PLF+PTH.
Report a problemFND-2654245703
04AnimalAnimal study (in vivo)Mechanism
In ovariectomized rats, PTH decreased ADAMTS-4 expression.
In plain wordsIn rats, PTH decreased ADAMTS-4 expression.
Peptide
Teriparatide (PTH 1-34)
Outcome
DecreaseADAMTS-4 expression
Study
ratn: not reported in source
Ovariectomized lumbar fusion model
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · 8 weeksAs given in this study (rat).
Source sentences
Summary
Moreover, protein expression results showed that PTH(1-34) not only inhibited matrix degradation by decreasing MMP-13, ADAMTS-4 and Col-I, but also promote matrix synthesis by increasing Col-II and Aggrecan.
2 context sentences(design, population, supporting numbers)
Summary · context
In the present study, we evaluated the effects of intermittent PTH(1-34) on ASDD in an ovariectomized (OVX) rat model.
Summary · context
PTH(1-34) was intermittently administered immediately after PLF surgery and lasted for 8 weeks using the following groups (n = 20) (V = vehicle): Sham+V, OVX+V, Sham+PLF+V, OVX+PLF+V, OVX+PLF+PTH.
Report a problemFND-2654245704
05AnimalAnimal study (in vivo)Mechanism
In ovariectomized rats, PTH decreased Col-I expression.
In plain wordsIn rats, PTH decreased Col-I expression.
Peptide
Teriparatide (PTH 1-34)
Outcome
DecreaseCol-I expression
Study
ratn: not reported in source
Ovariectomized lumbar fusion model
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · 8 weeksAs given in this study (rat).
Source sentences
Summary
Moreover, protein expression results showed that PTH(1-34) not only inhibited matrix degradation by decreasing MMP-13, ADAMTS-4 and Col-I, but also promote matrix synthesis by increasing Col-II and Aggrecan.
2 context sentences(design, population, supporting numbers)
Summary · context
In the present study, we evaluated the effects of intermittent PTH(1-34) on ASDD in an ovariectomized (OVX) rat model.
Summary · context
PTH(1-34) was intermittently administered immediately after PLF surgery and lasted for 8 weeks using the following groups (n = 20) (V = vehicle): Sham+V, OVX+V, Sham+PLF+V, OVX+PLF+V, OVX+PLF+PTH.
Report a problemFND-2654245705
06AnimalAnimal study (in vivo)Mechanism
In ovariectomized rats, PTH increased Col-II expression.
In plain wordsIn rats, PTH increased Col-II expression.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseCol-II expression
Study
ratn: not reported in source
Ovariectomized lumbar fusion model
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · 8 weeksAs given in this study (rat).
Source sentences
Summary
Moreover, protein expression results showed that PTH(1-34) not only inhibited matrix degradation by decreasing MMP-13, ADAMTS-4 and Col-I, but also promote matrix synthesis by increasing Col-II and Aggrecan.
2 context sentences(design, population, supporting numbers)
Summary · context
In the present study, we evaluated the effects of intermittent PTH(1-34) on ASDD in an ovariectomized (OVX) rat model.
Summary · context
PTH(1-34) was intermittently administered immediately after PLF surgery and lasted for 8 weeks using the following groups (n = 20) (V = vehicle): Sham+V, OVX+V, Sham+PLF+V, OVX+PLF+V, OVX+PLF+PTH.
Report a problemFND-2654245706
07AnimalAnimal study (in vivo)Mechanism
In ovariectomized rats, PTH increased Aggrecan expression.
In plain wordsIn rats, PTH increased Aggrecan expression.
Peptide
Teriparatide (PTH 1-34)
Outcome
IncreaseAggrecan expression
Study
ratn: not reported in source
Ovariectomized lumbar fusion model
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated · 8 weeksAs given in this study (rat).
Source sentences
Summary
Moreover, protein expression results showed that PTH(1-34) not only inhibited matrix degradation by decreasing MMP-13, ADAMTS-4 and Col-I, but also promote matrix synthesis by increasing Col-II and Aggrecan.
2 context sentences(design, population, supporting numbers)
Summary · context
In the present study, we evaluated the effects of intermittent PTH(1-34) on ASDD in an ovariectomized (OVX) rat model.
Summary · context
PTH(1-34) was intermittently administered immediately after PLF surgery and lasted for 8 weeks using the following groups (n = 20) (V = vehicle): Sham+V, OVX+V, Sham+PLF+V, OVX+PLF+V, OVX+PLF+PTH.
Report a problemFND-2654245707

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

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