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Study · Case report or series · n = 4 · 2015

2 results

Teriparatide in Fracture Non-Unions.

Coppola C, Del Buono A, Maffulli N

Translational medicine @ UniSa1 Sept 2014Cited by 18 (Europe PMC)

PMID26535187 (opens in a new tab)PMCIDPMC4592043 (opens in a new tab)PepBankPUB-26535187
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Summary

BackgroundThe use of teriparatide in the management of fracture disorders is poorly documented. This study aims to show that teriparatide administration may improve the healing process in patients with nonunions after open fixation of traumatic fractures of the lower limb.MethodsFour patients received Teriparatide for management of non-unions after open fixation of traumatic fractures of the lower limb.ResultsTeriparatide administration resulted in adequate bone callus over the site of nonunion in all the patients, and clinical and radiographic evidence of sound union.ConclusionsThe efficacy of teriparatide in delayed or non unions is still unclear. It may induce an angiogenetic response which counteracts the features responsible for development of non-union.Level of evidenceLevel IV, therapeutic case series.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanCase report or seriesEfficacy outcome

    All four patients with lower-limb fracture nonunion developed adequate bone callus during teriparatide treatment.

    In plain wordsAll four patients with lower-limb fracture nonunion developed adequate bone callus during teriparatide treatment.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    Not applicableBone callus at nonunion
    Study

    n = 4

    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Teriparatide administration resulted in adequate bone callus over the site of nonunion in all the patients, and clinical and radiographic evidence of sound union.
    1 context sentence
    Summary · context
    Four patients received Teriparatide for management of non-unions after open fixation of traumatic fractures of the lower limb.
  2. 02HumanCase report or seriesEfficacy outcome

    Patients with lower-limb fracture nonunion showed clinical and radiographic evidence of sound union during teriparatide treatment.

    In plain wordsPatients with lower-limb fracture nonunion showed clinical and imaging evidence of bone union during teriparatide treatment.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    Not applicableClinical and radiographic union
    Study

    n = 4

    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Teriparatide administration resulted in adequate bone callus over the site of nonunion in all the patients, and clinical and radiographic evidence of sound union.
    1 context sentence
    Summary · context
    Four patients received Teriparatide for management of non-unions after open fixation of traumatic fractures of the lower limb.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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