Comparative effects of whey protein versus L-leucine on skeletal muscle protein synthesis and markers of ribosome biogenesis following resistance exercise.

Mobley CB, Fox CD, Thompson RM, Healy JC, Santucci V, Kephart WC, McCloskey AE, Kim M, Pascoe DD, Martin JS, Moon JR, Young KC, Roberts MD

Amino acids27 Oct 2015Cited by 25 (Europe PMC)

PMID26507545DOI10.1007/s00726-015-2121-zPepBankPUB-26507545

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking AICAR (acadesine).

01LabNot a test of AICAR (acadesine) aloneIn vitro (cells)Mechanism
In C2C12 myotubes, exercise-like treatments including AICAR similarly altered ribosome biogenesis markers.
In plain wordsIn cells, exercise-like treatments including AICAR changed ribosome biogenesis markers.
Peptide
AICAR (acadesine)
Outcome
Direction not reportedRibosome biogenesis markers
Study
n: not reported in source
differentiated C2C12 myotubes
Outcome group
Receptor activity and mechanism · Musculoskeletal
Source sentences
Summary
In vitro findings confirmed that 'exercise-like' treatments similarly altered markers of ribosome biogenesis, but only LEU increased 47S pre-rRNA levels (P < 0.01).
1 context sentence(design, population, supporting numbers)
Summary · context
Additionally, in vitro experiments were performed on differentiated C2C12 myotubes to compare nutrient (i.e., WP, LEU) and 'exercise-like' treatments (i.e., caffeine, hydrogen peroxide, and AICAR) on ribosome biogenesis markers.
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
Report a problemFND-2650754501
02LabNot a test of AICAR (acadesine) aloneIn vitro (cells)Mechanism
In C2C12 myotubes, exercise-like treatments including AICAR did not significantly increase 47S pre-rRNA levels; only leucine did.
In plain wordsIn cells, exercise-like treatments including AICAR did not significantly increase 47S pre-rRNA levels; only leucine did.
Peptide
AICAR (acadesine)
Outcome
No significant change47S pre-rRNA levels
Study
n: not reported in source
differentiated C2C12 myotubes
Outcome group
Receptor activity and mechanism · Musculoskeletal
Source sentences
Summary
In vitro findings confirmed that 'exercise-like' treatments similarly altered markers of ribosome biogenesis, but only LEU increased 47S pre-rRNA levels (P < 0.01).
1 context sentence(design, population, supporting numbers)
Summary · context
Additionally, in vitro experiments were performed on differentiated C2C12 myotubes to compare nutrient (i.e., WP, LEU) and 'exercise-like' treatments (i.e., caffeine, hydrogen peroxide, and AICAR) on ribosome biogenesis markers.
In this study, AICAR (acadesine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AICAR (acadesine).
Report a problemFND-2650754502

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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