In model membranes, LL‑37 formed a stable aggregate on negatively charged membranes that can likely produce toroidal pores until bound peptide exceeds a critical concentration.
In plain wordsIn lab tests, LL‑37 formed a stable cluster on negatively charged model membranes.
- Peptide
- LL-37
- Outcome
- Not applicableAggregation state on negatively charged membranes
- Study
n: not reported in source
Model lipid membranes of different composition and charge- Outcome group
- Receptor activity and mechanism · Pharmacology
- Studied dose
- Dose not stated
Source sentences
LL-37 interacts with negatively charged membranes forming a stable aggregate, which can likely produce toroidal pores until the amount of bound peptide exceeds a critical concentration.
1 context sentence(design, population, supporting numbers)
In this context, antimicrobial peptide LL-37 and two variants were studied in the presence of model membranes with different lipid compositions and charges.