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Study · Animal study (in vivo) · rat · 2016

10 results

Attenuation of Acute Phase Injury in Rat Intracranial Hemorrhage by Cerebrolysin that Inhibits Brain Edema and Inflammatory Response.

Yang Y, Zhang Y, Wang Z, Wang S, Gao M, Xu R, Liang C, Zhang H

Neurochemical research26 Oct 2015Cited by 29 (Europe PMC)

PMID26498936 (opens in a new tab)DOI10.1007/s11064-015-1745-4 (opens in a new tab)PepBankPUB-26498936
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with intracerebral hemorrhage, Cerebrolysin improved neurological behavior compared with saline.

    In plain wordsIn rats with brain hemorrhage, Cerebrolysin improved neurological behavior compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseNeurological behavior
    Study

    ratn: not reported in source

    Collagenase-induced intracerebral hemorrhage in adult rats
    Comparator
    ICH plus saline
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    5 ml/kg · intraperitoneallyAs given in this study (rat).

    Source sentences

    Summary
    It is found that cerebrolysin (5 ml/kg) improved the neurological behavior and reduced the ipsilateral brain water content and Evans blue dye extravasation.
    2 context sentences
    Summary · context
    The ICH model was induced by administration of type VII bacterial collagenase into the stratum of adult rats, which were then randomly divided into three groups: ICH + saline; ICH + Cerebrolysin (5 ml/kg) and sham.
    Summary · context
    Cerebrolysin or saline was administered intraperitoneally 1 h post surgery.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with intracerebral hemorrhage, Cerebrolysin reduced water content on the injured brain side compared with saline.

    In plain wordsIn rats with brain hemorrhage, Cerebrolysin reduced water content on the injured brain side compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseIpsilateral brain water content
    Study

    ratn: not reported in source

    Collagenase-induced intracerebral hemorrhage in adult rats
    Comparator
    ICH plus saline
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    5 ml/kg · intraperitoneallyAs given in this study (rat).

    Source sentences

    Summary
    It is found that cerebrolysin (5 ml/kg) improved the neurological behavior and reduced the ipsilateral brain water content and Evans blue dye extravasation.
    2 context sentences
    Summary · context
    The ICH model was induced by administration of type VII bacterial collagenase into the stratum of adult rats, which were then randomly divided into three groups: ICH + saline; ICH + Cerebrolysin (5 ml/kg) and sham.
    Summary · context
    Cerebrolysin or saline was administered intraperitoneally 1 h post surgery.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with intracerebral hemorrhage, Cerebrolysin reduced Evans blue dye leakage compared with saline.

    In plain wordsIn rats with brain hemorrhage, Cerebrolysin reduced Evans blue dye leakage compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseEvans blue dye extravasation
    Study

    ratn: not reported in source

    Collagenase-induced intracerebral hemorrhage in adult rats
    Comparator
    ICH plus saline
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    5 ml/kg · intraperitoneallyAs given in this study (rat).

    Source sentences

    Summary
    It is found that cerebrolysin (5 ml/kg) improved the neurological behavior and reduced the ipsilateral brain water content and Evans blue dye extravasation.
    2 context sentences
    Summary · context
    The ICH model was induced by administration of type VII bacterial collagenase into the stratum of adult rats, which were then randomly divided into three groups: ICH + saline; ICH + Cerebrolysin (5 ml/kg) and sham.
    Summary · context
    Cerebrolysin or saline was administered intraperitoneally 1 h post surgery.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats with intracerebral hemorrhage, Cerebrolysin reduced peri-hematomal IL-1β levels compared with saline.

    In plain wordsIn rats with brain hemorrhage, Cerebrolysin reduced peri-hematomal IL-1β levels compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseIL-1β levels
    Study

    ratn: not reported in source

    Collagenase-induced intracerebral hemorrhage in adult rats
    Comparator
    ICH plus saline
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    5 ml/kg · intraperitoneallyAs given in this study (rat).

    Source sentences

    Summary
    After cerebrolysin treated, the levels of pro-inflammatory factors and AQP4 in the peri-hematomal areas were markedly reduced and were accompanied with higher expression of TJPs.
    3 context sentences
    Summary · context
    The levels of pro-inflammatory factors (IL-1β, TNF-α and IL-6) were assayed by Real-time PCR and Elisa kits.
    Summary · context
    The ICH model was induced by administration of type VII bacterial collagenase into the stratum of adult rats, which were then randomly divided into three groups: ICH + saline; ICH + Cerebrolysin (5 ml/kg) and sham.
    Summary · context
    Cerebrolysin or saline was administered intraperitoneally 1 h post surgery.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In rats with intracerebral hemorrhage, Cerebrolysin reduced peri-hematomal TNF-α levels compared with saline.

    In plain wordsIn rats with brain hemorrhage, Cerebrolysin reduced peri-hematomal TNF-α levels compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseTNF-α levels
    Study

    ratn: not reported in source

    Collagenase-induced intracerebral hemorrhage in adult rats
    Comparator
    ICH plus saline
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    5 ml/kg · intraperitoneallyAs given in this study (rat).

    Source sentences

    Summary
    After cerebrolysin treated, the levels of pro-inflammatory factors and AQP4 in the peri-hematomal areas were markedly reduced and were accompanied with higher expression of TJPs.
    3 context sentences
    Summary · context
    The levels of pro-inflammatory factors (IL-1β, TNF-α and IL-6) were assayed by Real-time PCR and Elisa kits.
    Summary · context
    The ICH model was induced by administration of type VII bacterial collagenase into the stratum of adult rats, which were then randomly divided into three groups: ICH + saline; ICH + Cerebrolysin (5 ml/kg) and sham.
    Summary · context
    Cerebrolysin or saline was administered intraperitoneally 1 h post surgery.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In rats with intracerebral hemorrhage, Cerebrolysin reduced peri-hematomal IL-6 levels compared with saline.

    In plain wordsIn rats with brain hemorrhage, Cerebrolysin reduced peri-hematomal IL-6 levels compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseIL-6 levels
    Study

    ratn: not reported in source

    Collagenase-induced intracerebral hemorrhage in adult rats
    Comparator
    ICH plus saline
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    5 ml/kg · intraperitoneallyAs given in this study (rat).

    Source sentences

    Summary
    After cerebrolysin treated, the levels of pro-inflammatory factors and AQP4 in the peri-hematomal areas were markedly reduced and were accompanied with higher expression of TJPs.
    3 context sentences
    Summary · context
    The levels of pro-inflammatory factors (IL-1β, TNF-α and IL-6) were assayed by Real-time PCR and Elisa kits.
    Summary · context
    The ICH model was induced by administration of type VII bacterial collagenase into the stratum of adult rats, which were then randomly divided into three groups: ICH + saline; ICH + Cerebrolysin (5 ml/kg) and sham.
    Summary · context
    Cerebrolysin or saline was administered intraperitoneally 1 h post surgery.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In rats with intracerebral hemorrhage, Cerebrolysin reduced peri-hematomal AQP4 levels compared with saline.

    In plain wordsIn rats with brain hemorrhage, Cerebrolysin reduced peri-hematomal AQP4 levels compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseAQP4 levels
    Study

    ratn: not reported in source

    Collagenase-induced intracerebral hemorrhage in adult rats
    Comparator
    ICH plus saline
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    5 ml/kg · intraperitoneallyAs given in this study (rat).

    Source sentences

    Summary
    After cerebrolysin treated, the levels of pro-inflammatory factors and AQP4 in the peri-hematomal areas were markedly reduced and were accompanied with higher expression of TJPs.
    2 context sentences
    Summary · context
    The ICH model was induced by administration of type VII bacterial collagenase into the stratum of adult rats, which were then randomly divided into three groups: ICH + saline; ICH + Cerebrolysin (5 ml/kg) and sham.
    Summary · context
    Cerebrolysin or saline was administered intraperitoneally 1 h post surgery.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In rats with intracerebral hemorrhage, Cerebrolysin accompanied higher claudin-5 expression compared with saline.

    In plain wordsIn rats with brain hemorrhage, Cerebrolysin accompanied higher claudin-5 expression compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseClaudin-5 expression
    Study

    ratn: not reported in source

    Collagenase-induced intracerebral hemorrhage in adult rats
    Comparator
    ICH plus saline
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    5 ml/kg · intraperitoneallyAs given in this study (rat).

    Source sentences

    Summary
    After cerebrolysin treated, the levels of pro-inflammatory factors and AQP4 in the peri-hematomal areas were markedly reduced and were accompanied with higher expression of TJPs.
    3 context sentences
    Summary · context
    Aquaporin-4 (AQP4) and tight junction proteins (TJPs; claudin-5, occludin and zonula occluden-1) expression were measured at multiple time points.
    Summary · context
    The ICH model was induced by administration of type VII bacterial collagenase into the stratum of adult rats, which were then randomly divided into three groups: ICH + saline; ICH + Cerebrolysin (5 ml/kg) and sham.
    Summary · context
    Cerebrolysin or saline was administered intraperitoneally 1 h post surgery.
  9. 09AnimalAnimal study (in vivo)Mechanism

    In rats with intracerebral hemorrhage, Cerebrolysin accompanied higher occludin expression compared with saline.

    In plain wordsIn rats with brain hemorrhage, Cerebrolysin accompanied higher occludin expression compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseOccludin expression
    Study

    ratn: not reported in source

    Collagenase-induced intracerebral hemorrhage in adult rats
    Comparator
    ICH plus saline
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    5 ml/kg · intraperitoneallyAs given in this study (rat).

    Source sentences

    Summary
    After cerebrolysin treated, the levels of pro-inflammatory factors and AQP4 in the peri-hematomal areas were markedly reduced and were accompanied with higher expression of TJPs.
    3 context sentences
    Summary · context
    Aquaporin-4 (AQP4) and tight junction proteins (TJPs; claudin-5, occludin and zonula occluden-1) expression were measured at multiple time points.
    Summary · context
    The ICH model was induced by administration of type VII bacterial collagenase into the stratum of adult rats, which were then randomly divided into three groups: ICH + saline; ICH + Cerebrolysin (5 ml/kg) and sham.
    Summary · context
    Cerebrolysin or saline was administered intraperitoneally 1 h post surgery.
  10. 10AnimalAnimal study (in vivo)Mechanism

    In rats with intracerebral hemorrhage, Cerebrolysin accompanied higher zonula occluden-1 expression compared with saline.

    In plain wordsIn rats with brain hemorrhage, Cerebrolysin accompanied higher zonula occluden-1 expression compared with saline.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseZonula occluden-1 expression
    Study

    ratn: not reported in source

    Collagenase-induced intracerebral hemorrhage in adult rats
    Comparator
    ICH plus saline
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    5 ml/kg · intraperitoneallyAs given in this study (rat).

    Source sentences

    Summary
    After cerebrolysin treated, the levels of pro-inflammatory factors and AQP4 in the peri-hematomal areas were markedly reduced and were accompanied with higher expression of TJPs.
    3 context sentences
    Summary · context
    Aquaporin-4 (AQP4) and tight junction proteins (TJPs; claudin-5, occludin and zonula occluden-1) expression were measured at multiple time points.
    Summary · context
    The ICH model was induced by administration of type VII bacterial collagenase into the stratum of adult rats, which were then randomly divided into three groups: ICH + saline; ICH + Cerebrolysin (5 ml/kg) and sham.
    Summary · context
    Cerebrolysin or saline was administered intraperitoneally 1 h post surgery.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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