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Study · Randomized controlled trial · 2015

3 results

Oxytocin enhances orienting to social information in a selective group of high-functioning male adults with autism spectrum disorder.

Althaus M, Groen Y, Wijers AA, Noltes H, Tucha O, Hoekstra PJ

Neuropsychologia23 Oct 2015Cited by 43 (Europe PMC)

PMID26498227 (opens in a new tab)DOI10.1016/j.neuropsychologia.2015.10.025 (opens in a new tab)PepBankPUB-26498227
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In male adults with and without autism spectrum disorder, intranasal oxytocin had no significant overall treatment effect on orienting responses.

    In plain wordsIn adult men with and without autism, nasal oxytocin had no overall effect on orienting responses compared with placebo.

    Peptide
    Oxytocin
    Outcome
    No significant changeCardiac and cortical orienting to affective pictures
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    No significant group differences were found, nor were there any treatment effects.
    1 context sentence
    Summary · context
    All subjects participated in a randomised double-blind placebo controlled crossover trial where either oxytocin (OXT) or placebo was administered preceding the viewing of affective pictures.The pictures, selected from the International Affective Picture System (IAPS), represented a systematic variat…
  2. 02HumanRandomized controlled trialEfficacy outcome

    In male adults with ASD who are easily distressed by others in stressful situations, moderator analysis showed oxytocin enhanced orienting to affective pictures with humans.

    In plain wordsIn adult men with autism who are easily distressed, nasal oxytocin increased orienting to pictures with people compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseOrienting to pictures with humans in ASD adults who are easily distressed
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    OXT did enhance orienting to affective pictures with humansin male adults with ASD who are easily distressed when seeing others in stressful situations
    1 context sentence
    Summary · context
    All subjects participated in a randomised double-blind placebo controlled crossover trial where either oxytocin (OXT) or placebo was administered preceding the viewing of affective pictures.The pictures, selected from the International Affective Picture System (IAPS), represented a systematic variat…
  3. 03HumanRandomized controlled trialEfficacy outcome

    In healthy males who are highly sensitive to anticipated punishment and criticism or have a low drive for goal achievement, moderator analysis showed oxytocin enhanced orienting to affective pictures with humans.

    In plain wordsIn healthy men sensitive to criticism or with low drive, nasal oxytocin increased orienting to pictures with people compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseOrienting to pictures with humans in healthy males sensitive to punishment
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Social behavior and cognition · Nervous system and cognition
    Studied dose
    Dose not stated · intranasalAs given in this study (human).

    Source sentences

    Summary
    in healthy males who are highly sensitive to anticipated punishment and criticism or have a low drive for goal achievement
    1 context sentence
    Summary · context
    All subjects participated in a randomised double-blind placebo controlled crossover trial where either oxytocin (OXT) or placebo was administered preceding the viewing of affective pictures.The pictures, selected from the International Affective Picture System (IAPS), represented a systematic variat…

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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