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Study · Animal study (in vivo) · sheep · 2016

19 results

A Selective V(1A) Receptor Agonist, Selepressin, Is Superior to Arginine Vasopressin and to Norepinephrine in Ovine Septic Shock.

He X, Su F, Taccone FS, Laporte R, Kjølbye AL, Zhang J, Xie K, Moussa MD, Reinheimer TM, Vincent JL

Critical care medicine1 Jan 2016Cited by 64 (Europe PMC)

PMID26496451 (opens in a new tab)PMCIDPMC4684247 (opens in a new tab)DOI10.1097/ccm.0000000000001380 (opens in a new tab)PepBankPUB-26496451
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study19

19 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In sheep with septic shock, selepressin-treated animals survived longer than the other study animals.

    In plain wordsIn sheep with septic shock, selepressin-treated animals lived longer than the other study animals.

    Peptide
    Selepressin
    Outcome
    IncreaseSurvival duration
    Study

    sheepn = 46

    Fecal peritonitis septic shock
    Comparator
    Other study animals
    Outcome group
    Mortality · Whole body
    Studied dose
    Initially 1 pmol/kg/min, then titrated · IV · Until death or maximum 30 hoursAs given in this study (sheep).

    Source sentences

    Summary
    Selepressin-treated animals survived longer than the other animals.
    2 context sentences
    Summary · context
    We compared the effects of selepressin, a selective V(1A) receptor agonist, arginine vasopressin, and norepinephrine on hemodynamics, organ function, and survival in an ovine septic shock model.
    Summary · context
    Fecal peritonitis was induced in the anesthetized, mechanically ventilated, fluid-resuscitated sheep, and they were randomized in two successive phases.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In septic sheep receiving early intervention, selepressin maintained arterial pressure better than arginine vasopressin.

    In plain wordsIn sheep with septic shock, early selepressin maintained blood pressure better than arginine vasopressin.

    Peptide
    Selepressin
    Outcome
    IncreaseEarly-intervention mean arterial pressure
    Study

    sheepn = 14

    Fecal peritonitis septic shock
    Comparator
    Arginine vasopressin
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    Initially 1 pmol/kg/min, then titrated · IV · Until death or maximum 30 hoursAs given in this study (sheep).

    Source sentences

    Summary
    In the early-intervention groups, selepressin maintained mean arterial pressure and cardiac index better than arginine vasopressin or norepinephrine, slowed the increase in blood lactate levels, and was associated with less lung edema, lower cumulative fluid balance, and lower interleukin-6 and nitrite/nitrate levels.
    3 context sentences
    Summary · context
    Three early-intervention groups (each n = 7) received selepressin, arginine vasopressin, or norepinephrine at the same initial infusion rates as for the late intervention, but already when mean arterial pressure had decreased by 10% from baseline; doses were then titrated as for the late intervention.
    Summary · context
    We compared the effects of selepressin, a selective V(1A) receptor agonist, arginine vasopressin, and norepinephrine on hemodynamics, organ function, and survival in an ovine septic shock model.
    Summary · context
    Fecal peritonitis was induced in the anesthetized, mechanically ventilated, fluid-resuscitated sheep, and they were randomized in two successive phases.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In septic sheep receiving early intervention, selepressin maintained arterial pressure better than norepinephrine.

    In plain wordsIn sheep with septic shock, early selepressin maintained blood pressure better than norepinephrine.

    Peptide
    Selepressin
    Outcome
    IncreaseEarly-intervention mean arterial pressure
    Study

    sheepn = 14

    Fecal peritonitis septic shock
    Comparator
    Norepinephrine
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    Initially 1 pmol/kg/min, then titrated · IV · Until death or maximum 30 hoursAs given in this study (sheep).

    Source sentences

    Summary
    In the early-intervention groups, selepressin maintained mean arterial pressure and cardiac index better than arginine vasopressin or norepinephrine, slowed the increase in blood lactate levels, and was associated with less lung edema, lower cumulative fluid balance, and lower interleukin-6 and nitrite/nitrate levels.
    3 context sentences
    Summary · context
    Three early-intervention groups (each n = 7) received selepressin, arginine vasopressin, or norepinephrine at the same initial infusion rates as for the late intervention, but already when mean arterial pressure had decreased by 10% from baseline; doses were then titrated as for the late intervention.
    Summary · context
    We compared the effects of selepressin, a selective V(1A) receptor agonist, arginine vasopressin, and norepinephrine on hemodynamics, organ function, and survival in an ovine septic shock model.
    Summary · context
    Fecal peritonitis was induced in the anesthetized, mechanically ventilated, fluid-resuscitated sheep, and they were randomized in two successive phases.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In septic sheep receiving early intervention, selepressin maintained cardiac index better than arginine vasopressin.

    In plain wordsIn sheep with septic shock, early selepressin maintained cardiac pumping better than arginine vasopressin.

    Peptide
    Selepressin
    Outcome
    IncreaseEarly-intervention cardiac index
    Study

    sheepn = 14

    Fecal peritonitis septic shock
    Comparator
    Arginine vasopressin
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Initially 1 pmol/kg/min, then titrated · IV · Until death or maximum 30 hoursAs given in this study (sheep).

    Source sentences

    Summary
    In the early-intervention groups, selepressin maintained mean arterial pressure and cardiac index better than arginine vasopressin or norepinephrine, slowed the increase in blood lactate levels, and was associated with less lung edema, lower cumulative fluid balance, and lower interleukin-6 and nitrite/nitrate levels.
    3 context sentences
    Summary · context
    Three early-intervention groups (each n = 7) received selepressin, arginine vasopressin, or norepinephrine at the same initial infusion rates as for the late intervention, but already when mean arterial pressure had decreased by 10% from baseline; doses were then titrated as for the late intervention.
    Summary · context
    We compared the effects of selepressin, a selective V(1A) receptor agonist, arginine vasopressin, and norepinephrine on hemodynamics, organ function, and survival in an ovine septic shock model.
    Summary · context
    Fecal peritonitis was induced in the anesthetized, mechanically ventilated, fluid-resuscitated sheep, and they were randomized in two successive phases.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In septic sheep receiving early intervention, selepressin maintained cardiac index better than norepinephrine.

    In plain wordsIn sheep with septic shock, early selepressin maintained cardiac pumping better than norepinephrine.

    Peptide
    Selepressin
    Outcome
    IncreaseEarly-intervention cardiac index
    Study

    sheepn = 14

    Fecal peritonitis septic shock
    Comparator
    Norepinephrine
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Initially 1 pmol/kg/min, then titrated · IV · Until death or maximum 30 hoursAs given in this study (sheep).

    Source sentences

    Summary
    In the early-intervention groups, selepressin maintained mean arterial pressure and cardiac index better than arginine vasopressin or norepinephrine, slowed the increase in blood lactate levels, and was associated with less lung edema, lower cumulative fluid balance, and lower interleukin-6 and nitrite/nitrate levels.
    3 context sentences
    Summary · context
    Three early-intervention groups (each n = 7) received selepressin, arginine vasopressin, or norepinephrine at the same initial infusion rates as for the late intervention, but already when mean arterial pressure had decreased by 10% from baseline; doses were then titrated as for the late intervention.
    Summary · context
    We compared the effects of selepressin, a selective V(1A) receptor agonist, arginine vasopressin, and norepinephrine on hemodynamics, organ function, and survival in an ovine septic shock model.
    Summary · context
    Fecal peritonitis was induced in the anesthetized, mechanically ventilated, fluid-resuscitated sheep, and they were randomized in two successive phases.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In septic sheep receiving early intervention, selepressin slowed the lactate increase compared with arginine vasopressin.

    In plain wordsIn sheep with septic shock, early selepressin slowed the blood lactate increase compared with arginine vasopressin.

    Peptide
    Selepressin
    Outcome
    DecreaseEarly-intervention blood lactate increase
    Study

    sheepn = 14

    Fecal peritonitis septic shock
    Comparator
    Arginine vasopressin
    Outcome group
    Vascular function · Cardiovascular
    Studied dose
    Initially 1 pmol/kg/min, then titrated · IV · Until death or maximum 30 hoursAs given in this study (sheep).

    Source sentences

    Summary
    In the early-intervention groups, selepressin maintained mean arterial pressure and cardiac index better than arginine vasopressin or norepinephrine, slowed the increase in blood lactate levels, and was associated with less lung edema, lower cumulative fluid balance, and lower interleukin-6 and nitrite/nitrate levels.
    3 context sentences
    Summary · context
    Three early-intervention groups (each n = 7) received selepressin, arginine vasopressin, or norepinephrine at the same initial infusion rates as for the late intervention, but already when mean arterial pressure had decreased by 10% from baseline; doses were then titrated as for the late intervention.
    Summary · context
    We compared the effects of selepressin, a selective V(1A) receptor agonist, arginine vasopressin, and norepinephrine on hemodynamics, organ function, and survival in an ovine septic shock model.
    Summary · context
    Fecal peritonitis was induced in the anesthetized, mechanically ventilated, fluid-resuscitated sheep, and they were randomized in two successive phases.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In septic sheep receiving early intervention, selepressin slowed the lactate increase compared with norepinephrine.

    In plain wordsIn sheep with septic shock, early selepressin slowed the blood lactate increase compared with norepinephrine.

    Peptide
    Selepressin
    Outcome
    DecreaseEarly-intervention blood lactate increase
    Study

    sheepn = 14

    Fecal peritonitis septic shock
    Comparator
    Norepinephrine
    Outcome group
    Vascular function · Cardiovascular
    Studied dose
    Initially 1 pmol/kg/min, then titrated · IV · Until death or maximum 30 hoursAs given in this study (sheep).

    Source sentences

    Summary
    In the early-intervention groups, selepressin maintained mean arterial pressure and cardiac index better than arginine vasopressin or norepinephrine, slowed the increase in blood lactate levels, and was associated with less lung edema, lower cumulative fluid balance, and lower interleukin-6 and nitrite/nitrate levels.
    3 context sentences
    Summary · context
    Three early-intervention groups (each n = 7) received selepressin, arginine vasopressin, or norepinephrine at the same initial infusion rates as for the late intervention, but already when mean arterial pressure had decreased by 10% from baseline; doses were then titrated as for the late intervention.
    Summary · context
    We compared the effects of selepressin, a selective V(1A) receptor agonist, arginine vasopressin, and norepinephrine on hemodynamics, organ function, and survival in an ovine septic shock model.
    Summary · context
    Fecal peritonitis was induced in the anesthetized, mechanically ventilated, fluid-resuscitated sheep, and they were randomized in two successive phases.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In septic sheep receiving early intervention, lung edema was lower with selepressin than arginine vasopressin.

    In plain wordsIn sheep with septic shock, early selepressin produced less lung fluid accumulation than arginine vasopressin.

    Peptide
    Selepressin
    Outcome
    DecreaseEarly-intervention lung edema
    Study

    sheepn = 14

    Fecal peritonitis septic shock
    Comparator
    Arginine vasopressin
    Outcome group
    Lung injury and fibrosis · Respiratory
    Studied dose
    Initially 1 pmol/kg/min, then titrated · IV · Until death or maximum 30 hoursAs given in this study (sheep).

    Source sentences

    Summary
    In the early-intervention groups, selepressin maintained mean arterial pressure and cardiac index better than arginine vasopressin or norepinephrine, slowed the increase in blood lactate levels, and was associated with less lung edema, lower cumulative fluid balance, and lower interleukin-6 and nitrite/nitrate levels.
    3 context sentences
    Summary · context
    Three early-intervention groups (each n = 7) received selepressin, arginine vasopressin, or norepinephrine at the same initial infusion rates as for the late intervention, but already when mean arterial pressure had decreased by 10% from baseline; doses were then titrated as for the late intervention.
    Summary · context
    We compared the effects of selepressin, a selective V(1A) receptor agonist, arginine vasopressin, and norepinephrine on hemodynamics, organ function, and survival in an ovine septic shock model.
    Summary · context
    Fecal peritonitis was induced in the anesthetized, mechanically ventilated, fluid-resuscitated sheep, and they were randomized in two successive phases.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In septic sheep receiving early intervention, lung edema was lower with selepressin than norepinephrine.

    In plain wordsIn sheep with septic shock, early selepressin produced less lung fluid accumulation than norepinephrine.

    Peptide
    Selepressin
    Outcome
    DecreaseEarly-intervention lung edema
    Study

    sheepn = 14

    Fecal peritonitis septic shock
    Comparator
    Norepinephrine
    Outcome group
    Lung injury and fibrosis · Respiratory
    Studied dose
    Initially 1 pmol/kg/min, then titrated · IV · Until death or maximum 30 hoursAs given in this study (sheep).

    Source sentences

    Summary
    In the early-intervention groups, selepressin maintained mean arterial pressure and cardiac index better than arginine vasopressin or norepinephrine, slowed the increase in blood lactate levels, and was associated with less lung edema, lower cumulative fluid balance, and lower interleukin-6 and nitrite/nitrate levels.
    3 context sentences
    Summary · context
    Three early-intervention groups (each n = 7) received selepressin, arginine vasopressin, or norepinephrine at the same initial infusion rates as for the late intervention, but already when mean arterial pressure had decreased by 10% from baseline; doses were then titrated as for the late intervention.
    Summary · context
    We compared the effects of selepressin, a selective V(1A) receptor agonist, arginine vasopressin, and norepinephrine on hemodynamics, organ function, and survival in an ovine septic shock model.
    Summary · context
    Fecal peritonitis was induced in the anesthetized, mechanically ventilated, fluid-resuscitated sheep, and they were randomized in two successive phases.
  10. 10AnimalAnimal study (in vivo)Efficacy outcome

    In septic sheep receiving early intervention, cumulative fluid balance was lower with selepressin than arginine vasopressin.

    In plain wordsIn sheep with septic shock, early selepressin produced less fluid accumulation than arginine vasopressin.

    Peptide
    Selepressin
    Outcome
    DecreaseEarly-intervention cumulative fluid balance
    Study

    sheepn = 14

    Fecal peritonitis septic shock
    Comparator
    Arginine vasopressin
    Outcome group
    Electrolyte balance · Whole body
    Studied dose
    Initially 1 pmol/kg/min, then titrated · IV · Until death or maximum 30 hoursAs given in this study (sheep).

    Source sentences

    Summary
    In the early-intervention groups, selepressin maintained mean arterial pressure and cardiac index better than arginine vasopressin or norepinephrine, slowed the increase in blood lactate levels, and was associated with less lung edema, lower cumulative fluid balance, and lower interleukin-6 and nitrite/nitrate levels.
    3 context sentences
    Summary · context
    Three early-intervention groups (each n = 7) received selepressin, arginine vasopressin, or norepinephrine at the same initial infusion rates as for the late intervention, but already when mean arterial pressure had decreased by 10% from baseline; doses were then titrated as for the late intervention.
    Summary · context
    We compared the effects of selepressin, a selective V(1A) receptor agonist, arginine vasopressin, and norepinephrine on hemodynamics, organ function, and survival in an ovine septic shock model.
    Summary · context
    Fecal peritonitis was induced in the anesthetized, mechanically ventilated, fluid-resuscitated sheep, and they were randomized in two successive phases.
  11. 11AnimalAnimal study (in vivo)Efficacy outcome

    In septic sheep receiving early intervention, cumulative fluid balance was lower with selepressin than norepinephrine.

    In plain wordsIn sheep with septic shock, early selepressin produced less fluid accumulation than norepinephrine.

    Peptide
    Selepressin
    Outcome
    DecreaseEarly-intervention cumulative fluid balance
    Study

    sheepn = 14

    Fecal peritonitis septic shock
    Comparator
    Norepinephrine
    Outcome group
    Electrolyte balance · Whole body
    Studied dose
    Initially 1 pmol/kg/min, then titrated · IV · Until death or maximum 30 hoursAs given in this study (sheep).

    Source sentences

    Summary
    In the early-intervention groups, selepressin maintained mean arterial pressure and cardiac index better than arginine vasopressin or norepinephrine, slowed the increase in blood lactate levels, and was associated with less lung edema, lower cumulative fluid balance, and lower interleukin-6 and nitrite/nitrate levels.
    3 context sentences
    Summary · context
    Three early-intervention groups (each n = 7) received selepressin, arginine vasopressin, or norepinephrine at the same initial infusion rates as for the late intervention, but already when mean arterial pressure had decreased by 10% from baseline; doses were then titrated as for the late intervention.
    Summary · context
    We compared the effects of selepressin, a selective V(1A) receptor agonist, arginine vasopressin, and norepinephrine on hemodynamics, organ function, and survival in an ovine septic shock model.
    Summary · context
    Fecal peritonitis was induced in the anesthetized, mechanically ventilated, fluid-resuscitated sheep, and they were randomized in two successive phases.
  12. 12AnimalAnimal study (in vivo)Efficacy outcome

    In septic sheep receiving early intervention, interleukin-6 levels were lower with selepressin than arginine vasopressin.

    In plain wordsIn sheep with septic shock, early selepressin produced lower interleukin-6 levels than arginine vasopressin.

    Peptide
    Selepressin
    Outcome
    DecreaseEarly-intervention interleukin-6
    Study

    sheepn = 14

    Fecal peritonitis septic shock
    Comparator
    Arginine vasopressin
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Initially 1 pmol/kg/min, then titrated · IV · Until death or maximum 30 hoursAs given in this study (sheep).

    Source sentences

    Summary
    In the early-intervention groups, selepressin maintained mean arterial pressure and cardiac index better than arginine vasopressin or norepinephrine, slowed the increase in blood lactate levels, and was associated with less lung edema, lower cumulative fluid balance, and lower interleukin-6 and nitrite/nitrate levels.
    3 context sentences
    Summary · context
    Three early-intervention groups (each n = 7) received selepressin, arginine vasopressin, or norepinephrine at the same initial infusion rates as for the late intervention, but already when mean arterial pressure had decreased by 10% from baseline; doses were then titrated as for the late intervention.
    Summary · context
    We compared the effects of selepressin, a selective V(1A) receptor agonist, arginine vasopressin, and norepinephrine on hemodynamics, organ function, and survival in an ovine septic shock model.
    Summary · context
    Fecal peritonitis was induced in the anesthetized, mechanically ventilated, fluid-resuscitated sheep, and they were randomized in two successive phases.
  13. 13AnimalAnimal study (in vivo)Efficacy outcome

    In septic sheep receiving early intervention, interleukin-6 levels were lower with selepressin than norepinephrine.

    In plain wordsIn sheep with septic shock, early selepressin produced lower interleukin-6 levels than norepinephrine.

    Peptide
    Selepressin
    Outcome
    DecreaseEarly-intervention interleukin-6
    Study

    sheepn = 14

    Fecal peritonitis septic shock
    Comparator
    Norepinephrine
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Initially 1 pmol/kg/min, then titrated · IV · Until death or maximum 30 hoursAs given in this study (sheep).

    Source sentences

    Summary
    In the early-intervention groups, selepressin maintained mean arterial pressure and cardiac index better than arginine vasopressin or norepinephrine, slowed the increase in blood lactate levels, and was associated with less lung edema, lower cumulative fluid balance, and lower interleukin-6 and nitrite/nitrate levels.
    3 context sentences
    Summary · context
    Three early-intervention groups (each n = 7) received selepressin, arginine vasopressin, or norepinephrine at the same initial infusion rates as for the late intervention, but already when mean arterial pressure had decreased by 10% from baseline; doses were then titrated as for the late intervention.
    Summary · context
    We compared the effects of selepressin, a selective V(1A) receptor agonist, arginine vasopressin, and norepinephrine on hemodynamics, organ function, and survival in an ovine septic shock model.
    Summary · context
    Fecal peritonitis was induced in the anesthetized, mechanically ventilated, fluid-resuscitated sheep, and they were randomized in two successive phases.
  14. 14AnimalAnimal study (in vivo)Efficacy outcome

    In septic sheep receiving early intervention, nitrite/nitrate levels were lower with selepressin than arginine vasopressin.

    In plain wordsIn sheep with septic shock, early selepressin produced lower nitrite/nitrate levels than arginine vasopressin.

    Peptide
    Selepressin
    Outcome
    DecreaseEarly-intervention nitrite/nitrate
    Study

    sheepn = 14

    Fecal peritonitis septic shock
    Comparator
    Arginine vasopressin
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Initially 1 pmol/kg/min, then titrated · IV · Until death or maximum 30 hoursAs given in this study (sheep).

    Source sentences

    Summary
    In the early-intervention groups, selepressin maintained mean arterial pressure and cardiac index better than arginine vasopressin or norepinephrine, slowed the increase in blood lactate levels, and was associated with less lung edema, lower cumulative fluid balance, and lower interleukin-6 and nitrite/nitrate levels.
    3 context sentences
    Summary · context
    Three early-intervention groups (each n = 7) received selepressin, arginine vasopressin, or norepinephrine at the same initial infusion rates as for the late intervention, but already when mean arterial pressure had decreased by 10% from baseline; doses were then titrated as for the late intervention.
    Summary · context
    We compared the effects of selepressin, a selective V(1A) receptor agonist, arginine vasopressin, and norepinephrine on hemodynamics, organ function, and survival in an ovine septic shock model.
    Summary · context
    Fecal peritonitis was induced in the anesthetized, mechanically ventilated, fluid-resuscitated sheep, and they were randomized in two successive phases.
  15. 15AnimalAnimal study (in vivo)Efficacy outcome

    In septic sheep receiving early intervention, nitrite/nitrate levels were lower with selepressin than norepinephrine.

    In plain wordsIn sheep with septic shock, early selepressin produced lower nitrite/nitrate levels than norepinephrine.

    Peptide
    Selepressin
    Outcome
    DecreaseEarly-intervention nitrite/nitrate
    Study

    sheepn = 14

    Fecal peritonitis septic shock
    Comparator
    Norepinephrine
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Initially 1 pmol/kg/min, then titrated · IV · Until death or maximum 30 hoursAs given in this study (sheep).

    Source sentences

    Summary
    In the early-intervention groups, selepressin maintained mean arterial pressure and cardiac index better than arginine vasopressin or norepinephrine, slowed the increase in blood lactate levels, and was associated with less lung edema, lower cumulative fluid balance, and lower interleukin-6 and nitrite/nitrate levels.
    3 context sentences
    Summary · context
    Three early-intervention groups (each n = 7) received selepressin, arginine vasopressin, or norepinephrine at the same initial infusion rates as for the late intervention, but already when mean arterial pressure had decreased by 10% from baseline; doses were then titrated as for the late intervention.
    Summary · context
    We compared the effects of selepressin, a selective V(1A) receptor agonist, arginine vasopressin, and norepinephrine on hemodynamics, organ function, and survival in an ovine septic shock model.
    Summary · context
    Fecal peritonitis was induced in the anesthetized, mechanically ventilated, fluid-resuscitated sheep, and they were randomized in two successive phases.
  16. 16AnimalAnimal study (in vivo)Efficacy outcome

    In septic sheep receiving late intervention, selepressin delayed the arterial pressure decrease compared with arginine vasopressin.

    In plain wordsIn sheep with septic shock, late selepressin delayed the blood pressure decrease compared with arginine vasopressin.

    Peptide
    Selepressin
    Outcome
    IncreaseLate-intervention mean arterial pressure
    Study

    sheepn = 12

    Fecal peritonitis septic shock
    Comparator
    Arginine vasopressin
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    Initially 1 pmol/kg/min, then titrated · IV · Until death or maximum 30 hoursAs given in this study (sheep).

    Source sentences

    Summary
    In the late-intervention groups, selepressin delayed the decrease in mean arterial pressure and was associated with lower lung wet/dry weight ratios than in the other two groups.
    3 context sentences
    Summary · context
    Three late-intervention groups (each n = 6) received IV selepressin (1 pmol/kg/min), arginine vasopressin (0.25 pmol [0.1 mU]/kg/min), or norepinephrine (3 nmol [0.5 μg]/kg/min) when mean arterial pressure remained less than 70 mm Hg despite fluid challenge; study drugs were thereafter titrated to k…
    Summary · context
    We compared the effects of selepressin, a selective V(1A) receptor agonist, arginine vasopressin, and norepinephrine on hemodynamics, organ function, and survival in an ovine septic shock model.
    Summary · context
    Fecal peritonitis was induced in the anesthetized, mechanically ventilated, fluid-resuscitated sheep, and they were randomized in two successive phases.
  17. 17AnimalAnimal study (in vivo)Efficacy outcome

    In septic sheep receiving late intervention, selepressin delayed the arterial pressure decrease compared with norepinephrine.

    In plain wordsIn sheep with septic shock, late selepressin delayed the blood pressure decrease compared with norepinephrine.

    Peptide
    Selepressin
    Outcome
    IncreaseLate-intervention mean arterial pressure
    Study

    sheepn = 12

    Fecal peritonitis septic shock
    Comparator
    Norepinephrine
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    Initially 1 pmol/kg/min, then titrated · IV · Until death or maximum 30 hoursAs given in this study (sheep).

    Source sentences

    Summary
    In the late-intervention groups, selepressin delayed the decrease in mean arterial pressure and was associated with lower lung wet/dry weight ratios than in the other two groups.
    3 context sentences
    Summary · context
    Three late-intervention groups (each n = 6) received IV selepressin (1 pmol/kg/min), arginine vasopressin (0.25 pmol [0.1 mU]/kg/min), or norepinephrine (3 nmol [0.5 μg]/kg/min) when mean arterial pressure remained less than 70 mm Hg despite fluid challenge; study drugs were thereafter titrated to k…
    Summary · context
    We compared the effects of selepressin, a selective V(1A) receptor agonist, arginine vasopressin, and norepinephrine on hemodynamics, organ function, and survival in an ovine septic shock model.
    Summary · context
    Fecal peritonitis was induced in the anesthetized, mechanically ventilated, fluid-resuscitated sheep, and they were randomized in two successive phases.
  18. 18AnimalAnimal study (in vivo)Efficacy outcome

    In septic sheep receiving late intervention, lung wet/dry weight ratios were lower with selepressin than arginine vasopressin.

    In plain wordsIn sheep with septic shock, late selepressin produced lower lung wet/dry weight ratios than arginine vasopressin.

    Peptide
    Selepressin
    Outcome
    DecreaseLate-intervention lung wet/dry weight ratio
    Study

    sheepn = 12

    Fecal peritonitis septic shock
    Comparator
    Arginine vasopressin
    Outcome group
    Lung injury and fibrosis · Respiratory
    Studied dose
    Initially 1 pmol/kg/min, then titrated · IV · Until death or maximum 30 hoursAs given in this study (sheep).

    Source sentences

    Summary
    In the late-intervention groups, selepressin delayed the decrease in mean arterial pressure and was associated with lower lung wet/dry weight ratios than in the other two groups.
    3 context sentences
    Summary · context
    Three late-intervention groups (each n = 6) received IV selepressin (1 pmol/kg/min), arginine vasopressin (0.25 pmol [0.1 mU]/kg/min), or norepinephrine (3 nmol [0.5 μg]/kg/min) when mean arterial pressure remained less than 70 mm Hg despite fluid challenge; study drugs were thereafter titrated to k…
    Summary · context
    We compared the effects of selepressin, a selective V(1A) receptor agonist, arginine vasopressin, and norepinephrine on hemodynamics, organ function, and survival in an ovine septic shock model.
    Summary · context
    Fecal peritonitis was induced in the anesthetized, mechanically ventilated, fluid-resuscitated sheep, and they were randomized in two successive phases.
  19. 19AnimalAnimal study (in vivo)Efficacy outcome

    In septic sheep receiving late intervention, lung wet/dry weight ratios were lower with selepressin than norepinephrine.

    In plain wordsIn sheep with septic shock, late selepressin produced lower lung wet/dry weight ratios than norepinephrine.

    Peptide
    Selepressin
    Outcome
    DecreaseLate-intervention lung wet/dry weight ratio
    Study

    sheepn = 12

    Fecal peritonitis septic shock
    Comparator
    Norepinephrine
    Outcome group
    Lung injury and fibrosis · Respiratory
    Studied dose
    Initially 1 pmol/kg/min, then titrated · IV · Until death or maximum 30 hoursAs given in this study (sheep).

    Source sentences

    Summary
    In the late-intervention groups, selepressin delayed the decrease in mean arterial pressure and was associated with lower lung wet/dry weight ratios than in the other two groups.
    3 context sentences
    Summary · context
    Three late-intervention groups (each n = 6) received IV selepressin (1 pmol/kg/min), arginine vasopressin (0.25 pmol [0.1 mU]/kg/min), or norepinephrine (3 nmol [0.5 μg]/kg/min) when mean arterial pressure remained less than 70 mm Hg despite fluid challenge; study drugs were thereafter titrated to k…
    Summary · context
    We compared the effects of selepressin, a selective V(1A) receptor agonist, arginine vasopressin, and norepinephrine on hemodynamics, organ function, and survival in an ovine septic shock model.
    Summary · context
    Fecal peritonitis was induced in the anesthetized, mechanically ventilated, fluid-resuscitated sheep, and they were randomized in two successive phases.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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