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Study · Animal study (in vivo) · rat · 2015

9 results

Modulating Effect of Peptide Therapy on the Morphofunctional State of Bronchial Epithelium in Rats with Obstructive Lung Pathology.

Kuzubova NA, Lebedeva ES, Dvorakovskaya IV, Surkova EA, Platonova IS, Titova ON

Bulletin of experimental biology and medicine1 Sept 2015

PMID26468022 (opens in a new tab)DOI10.1007/s10517-015-3047-x (opens in a new tab)PepBankPUB-26468022
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with COPD, Bronchogen eliminated goblet cell hyperplasia.

    In plain wordsIn rats with COPD, Bronchogen eliminated excessive goblet cell growth.

    Peptide
    Bronchogen (AEDL)
    Outcome
    DecreaseGoblet cell hyperplasia
    Study

    ratn: not reported in source

    NO2-induced COPD
    Outcome group
    Lung injury and fibrosis · Respiratory
    Studied dose
    Dose not stated · 1 monthAs given in this study (rat).

    Source sentences

    Summary
    Administration of tetrapeptide Bronchogen for 1 month eliminates symptoms of remodeling of the bronchial epithelium and lung tissue typical of chronic obstructive pulmonary disease (goblet cell hyperplasia, squamous metaplasia, lymphocytic infiltration and emphysema, and restoration of ciliated cells).
    1 context sentence
    Summary · context
    Chronic obstructive pulmonary disease was modeled in rats by 60-day intermittent exposure to NO2.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with COPD, Bronchogen eliminated squamous metaplasia.

    In plain wordsIn rats with COPD, Bronchogen eliminated squamous metaplasia in the airway lining.

    Peptide
    Bronchogen (AEDL)
    Outcome
    DecreaseSquamous metaplasia
    Study

    ratn: not reported in source

    NO2-induced COPD
    Outcome group
    Lung injury and fibrosis · Respiratory
    Studied dose
    Dose not stated · 1 monthAs given in this study (rat).

    Source sentences

    Summary
    Administration of tetrapeptide Bronchogen for 1 month eliminates symptoms of remodeling of the bronchial epithelium and lung tissue typical of chronic obstructive pulmonary disease (goblet cell hyperplasia, squamous metaplasia, lymphocytic infiltration and emphysema, and restoration of ciliated cells).
    1 context sentence
    Summary · context
    Chronic obstructive pulmonary disease was modeled in rats by 60-day intermittent exposure to NO2.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with COPD, Bronchogen eliminated lymphocytic infiltration.

    In plain wordsIn rats with COPD, Bronchogen eliminated lymphocyte infiltration in lung tissue.

    Peptide
    Bronchogen (AEDL)
    Outcome
    DecreaseLymphocytic infiltration
    Study

    ratn: not reported in source

    NO2-induced COPD
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated · 1 monthAs given in this study (rat).

    Source sentences

    Summary
    Administration of tetrapeptide Bronchogen for 1 month eliminates symptoms of remodeling of the bronchial epithelium and lung tissue typical of chronic obstructive pulmonary disease (goblet cell hyperplasia, squamous metaplasia, lymphocytic infiltration and emphysema, and restoration of ciliated cells).
    1 context sentence
    Summary · context
    Chronic obstructive pulmonary disease was modeled in rats by 60-day intermittent exposure to NO2.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with COPD, Bronchogen eliminated emphysema symptoms.

    In plain wordsIn rats with COPD, Bronchogen eliminated emphysema symptoms.

    Peptide
    Bronchogen (AEDL)
    Outcome
    DecreaseEmphysema
    Study

    ratn: not reported in source

    NO2-induced COPD
    Outcome group
    Lung injury and fibrosis · Respiratory
    Studied dose
    Dose not stated · 1 monthAs given in this study (rat).

    Source sentences

    Summary
    Administration of tetrapeptide Bronchogen for 1 month eliminates symptoms of remodeling of the bronchial epithelium and lung tissue typical of chronic obstructive pulmonary disease (goblet cell hyperplasia, squamous metaplasia, lymphocytic infiltration and emphysema, and restoration of ciliated cells).
    1 context sentence
    Summary · context
    Chronic obstructive pulmonary disease was modeled in rats by 60-day intermittent exposure to NO2.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats with COPD, Bronchogen restored ciliated cells.

    In plain wordsIn rats with COPD, Bronchogen restored ciliated cells in the airway lining.

    Peptide
    Bronchogen (AEDL)
    Outcome
    IncreaseCiliated cell restoration
    Study

    ratn: not reported in source

    NO2-induced COPD
    Outcome group
    Lung injury and fibrosis · Respiratory
    Studied dose
    Dose not stated · 1 monthAs given in this study (rat).

    Source sentences

    Summary
    Administration of tetrapeptide Bronchogen for 1 month eliminates symptoms of remodeling of the bronchial epithelium and lung tissue typical of chronic obstructive pulmonary disease (goblet cell hyperplasia, squamous metaplasia, lymphocytic infiltration and emphysema, and restoration of ciliated cells).
    1 context sentence
    Summary · context
    Chronic obstructive pulmonary disease was modeled in rats by 60-day intermittent exposure to NO2.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats with COPD, Bronchogen enhanced secretory IgA production.

    In plain wordsIn rats with COPD, Bronchogen increased secretory IgA production.

    Peptide
    Bronchogen (AEDL)
    Outcome
    IncreaseSecretory IgA production
    Study

    ratn: not reported in source

    NO2-induced COPD
    Outcome group
    Immune response · Respiratory
    Studied dose
    Dose not stated · 1 monthAs given in this study (rat).

    Source sentences

    Summary
    Enhanced production of secretory IgA, a local immunity marker, attested to normalization of functional activity of bronchial epithelium
    1 context sentence
    Summary · context
    Chronic obstructive pulmonary disease was modeled in rats by 60-day intermittent exposure to NO2.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In rats with COPD, Bronchogen normalized bronchoalveolar cell composition.

    In plain wordsIn rats with COPD, Bronchogen normalized the types of cells in lung lavage fluid.

    Peptide
    Bronchogen (AEDL)
    Outcome
    MixedBronchoalveolar cell composition
    Study

    ratn: not reported in source

    NO2-induced COPD
    Outcome group
    Immune response · Respiratory
    Studied dose
    Dose not stated · 1 monthAs given in this study (rat).

    Source sentences

    Summary
    while normalization of cell composition and profile of proinflammatory cytokines in the bronchoalveolar space reflected reduction of neutrophilic inflammation.
    1 context sentence
    Summary · context
    Chronic obstructive pulmonary disease was modeled in rats by 60-day intermittent exposure to NO2.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In rats with COPD, Bronchogen normalized the bronchoalveolar proinflammatory cytokine profile.

    In plain wordsIn rats with COPD, Bronchogen normalized the inflammatory cytokine profile in lung lavage fluid.

    Peptide
    Bronchogen (AEDL)
    Outcome
    MixedProinflammatory cytokine profile
    Study

    ratn: not reported in source

    NO2-induced COPD
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated · 1 monthAs given in this study (rat).

    Source sentences

    Summary
    while normalization of cell composition and profile of proinflammatory cytokines in the bronchoalveolar space reflected reduction of neutrophilic inflammation.
    1 context sentence
    Summary · context
    Chronic obstructive pulmonary disease was modeled in rats by 60-day intermittent exposure to NO2.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In rats with COPD, Bronchogen reduced neutrophilic inflammation.

    In plain wordsIn rats with COPD, Bronchogen reduced neutrophilic inflammation.

    Peptide
    Bronchogen (AEDL)
    Outcome
    DecreaseNeutrophilic inflammation
    Study

    ratn: not reported in source

    NO2-induced COPD
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated · 1 monthAs given in this study (rat).

    Source sentences

    Summary
    while normalization of cell composition and profile of proinflammatory cytokines in the bronchoalveolar space reflected reduction of neutrophilic inflammation.
    1 context sentence
    Summary · context
    Chronic obstructive pulmonary disease was modeled in rats by 60-day intermittent exposure to NO2.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 17:05 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

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