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Study · Randomized controlled trial · 2016

4 results

Oxytocin selectively modulates brain response to stimuli probing social synchrony.

Levy J, Goldstein A, Zagoory-Sharon O, Weisman O, Schneiderman I, Eidelman-Rothman M, Feldman R

NeuroImage9 Oct 2015Cited by 41 (Europe PMC)

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanRandomized controlled trialMechanism

    In male combat veterans, oxytocin attenuated the increased response to combat stimuli in the posterior superior temporal sulcus compared with placebo.

    In plain wordsIn male combat veterans, oxytocin reduced brain activity in a social perception area when viewing combat scenes, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    DecreasepSTS response to combat stimuli in combat veterans
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Among combat veterans, OT attenuated the increased response to combat stimuli in the posterior superior temporal sulcus (pSTS) - a hub of social perception, action observation, and mentalizing - and enhanced activation in the inferior parietal lobule (IPL) to the pleasant social scene.
    1 context sentence
    Summary · context
    Using a randomized, double-blind, within-subject design, 40 combat-trained and control male veterans underwent magnetoencephalography (MEG) twice following OT/placebo administration while viewing two social vignettes rated as highly synchronous: pleasant male social gathering and coordinated unit during combat.
  2. 02HumanRandomized controlled trialMechanism

    In male combat veterans, oxytocin enhanced activation in the inferior parietal lobule to the pleasant social scene compared with placebo.

    In plain wordsIn male combat veterans, oxytocin raised brain activity in a movement-understanding area when viewing a pleasant social scene, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseIPL activation to pleasant social scene in combat veterans
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Among combat veterans, OT attenuated the increased response to combat stimuli in the posterior superior temporal sulcus (pSTS) - a hub of social perception, action observation, and mentalizing - and enhanced activation in the inferior parietal lobule (IPL) to the pleasant social scene.
    1 context sentence
    Summary · context
    Using a randomized, double-blind, within-subject design, 40 combat-trained and control male veterans underwent magnetoencephalography (MEG) twice following OT/placebo administration while viewing two social vignettes rated as highly synchronous: pleasant male social gathering and coordinated unit during combat.
  3. 03HumanRandomized controlled trialMechanism

    In male control veterans, oxytocin enhanced inferior frontal gyrus response to combat cues compared with placebo.

    In plain wordsIn male control veterans, oxytocin raised activity in a brain area linked to mirroring others when viewing combat cues, compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseIFG response to combat cues in control veterans
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Among controls, OT enhanced inferior frontal gyrus (IFG) response to combat cues, demonstrating selective OT effects on mirror-neuron and mentalizing networks.
    1 context sentence
    Summary · context
    Using a randomized, double-blind, within-subject design, 40 combat-trained and control male veterans underwent magnetoencephalography (MEG) twice following OT/placebo administration while viewing two social vignettes rated as highly synchronous: pleasant male social gathering and coordinated unit during combat.
  4. 04HumanRandomized controlled trialMechanism

    In male veterans, oxytocin-enhanced mirror network activity was dampened in those who reported higher posttraumatic symptoms.

    In plain wordsIn male veterans, the oxytocin-linked rise in mirror network brain activity was smaller in those reporting more posttraumatic symptoms.

    Peptide
    Oxytocin
    Outcome
    Not applicableOxytocin-enhanced mirror network activity by posttraumatic symptoms
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    OT-enhanced mirror network activity was dampened in veterans reporting higher posttraumatic symptoms.
    1 context sentence
    Summary · context
    Using a randomized, double-blind, within-subject design, 40 combat-trained and control male veterans underwent magnetoencephalography (MEG) twice following OT/placebo administration while viewing two social vignettes rated as highly synchronous: pleasant male social gathering and coordinated unit during combat.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · 1 ongoing · source ClinicalTrials.gov (opens in a new tab)

RecruitingPhase 2NCT06364228

Intranasal Oxytocin Intervention for Caregivers to Persons With Dementia

University of Nebraskan = 32est. 20 Jun 2026 to est. Jun 2027

Stress

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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