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Study · In vitro (cells) · 2015

7 results

Increased IGF-IEc expression and mechano-growth factor production in intestinal muscle of fibrostenotic Crohn's disease and smooth muscle hypertrophy.

Li C, Vu K, Hazelgrove K, Kuemmerle JF

American journal of physiology. Gastrointestinal and liver physiology1 Oct 2015Cited by 16 (Europe PMC)

PMID26428636 (opens in a new tab)PMCIDPMC4669353 (opens in a new tab)DOI10.1152/ajpgi.00414.2014 (opens in a new tab)PepBankPUB-26428636
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In vitro, synthetic MGF caused phosphorylation of Erk5 and MEF2C.

    In plain wordsIn cells, synthetic MGF switched on the signalling proteins Erk5 and MEF2C.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseErk5 and MEF2C phosphorylation after synthetic MGF
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    both were phosphorylated and colocalized to nucleus in response to synthetic MGF in vitro.
  2. 02LabIn vitro (cells)Mechanism

    In vitro, synthetic MGF caused Erk5 and MEF2C to colocalize in the nucleus.

    In plain wordsIn cells, synthetic MGF moved the signalling proteins Erk5 and MEF2C together into the cell nucleus.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseErk5 and MEF2C nuclear colocalization after synthetic MGF
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    both were phosphorylated and colocalized to nucleus in response to synthetic MGF in vitro.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 03LabEndogenous levelEx vivo tissueMechanism

    In muscle cells isolated from fibrostenotic intestine in Crohn's disease, IGF-IEc transcripts were increased, under regulation by endogenous TGF-β1.

    In plain wordsIn cells from Crohn's disease gut, the body's own MGF gene activity (IGF-IEc) was higher.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseIGF-IEc transcript level in muscle cells from fibrostenotic intestine
    Study

    n: not reported in source

    Outcome group
    Endogenous peptide levels · Gastrointestinal

    Source sentences

    Summary
    IGF-IEc transcripts and MGF protein were increased in muscle cells isolated from fibrostenotic intestine under regulation by endogenous TGF-β1.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

  2. 04LabEndogenous levelEx vivo tissueMechanism

    In muscle cells isolated from fibrostenotic intestine in Crohn's disease, MGF protein was increased, under regulation by endogenous TGF-β1.

    In plain wordsIn cells from Crohn's disease gut, the body's own MGF protein was higher.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseMGF protein level in muscle cells from fibrostenotic intestine
    Study

    n: not reported in source

    Outcome group
    Endogenous peptide levels · Gastrointestinal

    Source sentences

    Summary
    IGF-IEc transcripts and MGF protein were increased in muscle cells isolated from fibrostenotic intestine under regulation by endogenous TGF-β1.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

Studies that did not test the peptide alone3

In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking MGF / PEG-MGF.

  1. 05LabNot a test of MGF / PEG-MGF aloneIn vitro (cells)Mechanism

    In vitro, Erk5 inhibition or MEF2C siRNA blocked smooth muscle-specific gene expression induced by synthetic MGF.

    In plain wordsIn cells, blocking Erk5 or MEF2C stopped the muscle gene activity that synthetic MGF caused.

    Peptide
    MGF / PEG-MGF
    Outcome
    DecreaseSmooth muscle-specific gene expression induced by synthetic MGF, after Erk5 inhibition or MEF2C siRNA
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Gastrointestinal

    Source sentences

    Summary
    Erk5 inhibition or MEF2C siRNA blocked smooth muscle-specific gene expression and hypertrophy induced by synthetic MGF.

    In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.

  2. 06LabNot a test of MGF / PEG-MGF aloneIn vitro (cells)Mechanism

    In vitro, Erk5 inhibition or MEF2C siRNA blocked hypertrophy induced by synthetic MGF.

    In plain wordsIn cells, blocking Erk5 or MEF2C stopped the muscle cell enlargement that synthetic MGF caused.

    Peptide
    MGF / PEG-MGF
    Outcome
    DecreaseHypertrophy induced by synthetic MGF, after Erk5 inhibition or MEF2C siRNA
    Study

    n: not reported in source

    Outcome group
    Cell proliferation and differentiation · Gastrointestinal

    Source sentences

    Summary
    Erk5 inhibition or MEF2C siRNA blocked smooth muscle-specific gene expression and hypertrophy induced by synthetic MGF.

    In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.

  3. 07LabNot a test of MGF / PEG-MGF aloneIn vitro (cells)Mechanism

    In vitro, immunoneutralization of endogenous MGF or pro-IGF-IEc inhibited muscle hypertrophy induced by conditioned media of cultured fibrostenotic muscle.

    In plain wordsIn cells, blocking the body's own MGF with antibodies reduced the muscle cell enlargement caused by media from Crohn's disease muscle.

    Peptide
    MGF / PEG-MGF
    Outcome
    DecreaseHypertrophy induced by fibrostenotic muscle conditioned media, after immunoneutralization of MGF or pro-IGF-IEc
    Study

    n: not reported in source

    Outcome group
    Cell proliferation and differentiation · Gastrointestinal

    Source sentences

    Summary
    Conditioned media of cultured fibrostenotic muscle induced muscle hypertrophy that was inhibited by immunoneutralization of endogenous MGF or pro-IGF-IEc.

    In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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