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Study · Measured the body's own peptide · 2015

3 results

Comparative effect of electroacupuncture and moxibustion on the expression of substance P and vasoactive intestinal peptide in patients with irritable bowel syndrome.

Zhenzhong L, Xiaojun Y, Weijun T, Yuehua C, Jie S, Jimeng Z, Anqi W, Chunhui B, Yin S

Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan1 Aug 2015Cited by 28 (Europe PMC)

PMID26427109 (opens in a new tab)DOI10.1016/s0254-6272(15)30116-3 (opens in a new tab)PepBankPUB-26427109
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelRandomized controlled trialOther

    In patients with irritable bowel syndrome, electroacupuncture lowered the abnormally raised expression of the body's own VIP in colonic mucosa.

    In plain wordsIn people with irritable bowel syndrome, electroacupuncture lowered the raised natural VIP levels in the colon lining.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    DecreaseColonic mucosal VIP expression after electroacupuncture
    Study

    n = 81

    Comparator
    Before treatment
    Outcome group
    Endogenous peptide levels · Gastrointestinal

    Source sentences

    Summary
    EA and Mox treatments both down-regulated the abnormally increased SP and VIP expression in the colonic mucosa, with no significant difference shown between the two treatments.
    2 context sentences
    Summary · context
    There were four dropout cases, leaving 81 participants (41 with IBS-D and 40 with IBS-C) who volunteered to undergo colonoscopy before and after the treatment sessions.
    Summary · context
    During colonoscopy, sigmoid mucosa were collected to detect SP and VIP expression using immunohistochemistry assay.

    This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelRandomized controlled trialOther

    In patients with irritable bowel syndrome, moxibustion lowered the abnormally raised expression of the body's own VIP in colonic mucosa.

    In plain wordsIn people with irritable bowel syndrome, moxibustion lowered the raised natural VIP levels in the colon lining.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    DecreaseColonic mucosal VIP expression after moxibustion
    Study

    n = 81

    Comparator
    Before treatment
    Outcome group
    Endogenous peptide levels · Gastrointestinal

    Source sentences

    Summary
    EA and Mox treatments both down-regulated the abnormally increased SP and VIP expression in the colonic mucosa, with no significant difference shown between the two treatments.
    2 context sentences
    Summary · context
    There were four dropout cases, leaving 81 participants (41 with IBS-D and 40 with IBS-C) who volunteered to undergo colonoscopy before and after the treatment sessions.
    Summary · context
    During colonoscopy, sigmoid mucosa were collected to detect SP and VIP expression using immunohistochemistry assay.

    This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelRandomized controlled trialOther

    In patients with irritable bowel syndrome, the fall in the body's own VIP expression in colonic mucosa did not differ between electroacupuncture and moxibustion.

    In plain wordsIn people with irritable bowel syndrome, electroacupuncture and moxibustion lowered natural colon VIP levels by a similar amount.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    No significant changeColonic mucosal VIP expression, electroacupuncture versus moxibustion
    Study

    n = 81

    Comparator
    Moxibustion versus electroacupuncture
    Outcome group
    Endogenous peptide levels · Gastrointestinal

    Source sentences

    Summary
    EA and Mox treatments both down-regulated the abnormally increased SP and VIP expression in the colonic mucosa, with no significant difference shown between the two treatments.
    2 context sentences
    Summary · context
    There were four dropout cases, leaving 81 participants (41 with IBS-D and 40 with IBS-C) who volunteered to undergo colonoscopy before and after the treatment sessions.
    Summary · context
    During colonoscopy, sigmoid mucosa were collected to detect SP and VIP expression using immunohistochemistry assay.

    This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 19:08 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 12:40 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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