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Study · Randomized controlled trial · n = 40 · 2016

3 results

Intranasal Oxytocin Administration Dampens Amygdala Reactivity towards Emotional Faces in Male and Female PTSD Patients.

Koch SB, van Zuiden M, Nawijn L, Frijling JL, Veltman DJ, Olff M

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology25 Sept 2015Cited by 84 (Europe PMC)

PMID26404844 (opens in a new tab)PMCIDPMC4832009 (opens in a new tab)DOI10.1038/npp.2015.299 (opens in a new tab)PepBankPUB-26404844
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanRandomized controlled trialMechanism

    In healthy male and female trauma-exposed police officers without PTSD, oxytocin enhanced amygdala reactivity toward emotional faces compared with placebo.

    In plain wordsIn trauma-exposed police officers without PTSD, oxytocin increased amygdala brain activity to emotional faces compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseAmygdala reactivity toward emotional faces in trauma-exposed controls
    Study

    n = 40

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    40 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    but enhanced amygdala reactivity in healthy male and female trauma-exposed controls, independent of sex and stimulus valence
    1 context sentence
    Summary · context
    As a first step to investigate the therapeutic potential of OT in PTSD, we conducted a double-blind, placebo-controlled, cross-over functional MRI study examining OT administration effects (40 IU) on amygdala reactivity toward emotional faces in unmedicated male and female police officers with (n=37…
  2. 02HumanRandomized controlled trialMechanism

    In male and female police officers with PTSD, oxytocin dampened amygdala reactivity toward all emotional faces compared with placebo.

    In plain wordsIn police officers with PTSD, oxytocin reduced amygdala brain activity to emotional faces compared with placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseAmygdala reactivity toward emotional faces in PTSD patients
    Study

    n = 37

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    40 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    OT administration dampened amygdala reactivity toward all emotional faces in male and female PTSD patients
    1 context sentence
    Summary · context
    As a first step to investigate the therapeutic potential of OT in PTSD, we conducted a double-blind, placebo-controlled, cross-over functional MRI study examining OT administration effects (40 IU) on amygdala reactivity toward emotional faces in unmedicated male and female police officers with (n=37…
  3. 03HumanRandomized controlled trialMechanism

    In PTSD patients, greater anxiety before scanning and greater amygdala reactivity under placebo were associated with a larger reduction of amygdala reactivity after oxytocin.

    In plain wordsIn police officers with PTSD, higher anxiety and higher amygdala activity under placebo were linked to a larger drop in amygdala activity after oxytocin.

    Peptide
    Oxytocin
    Outcome
    Not applicablePredictors of oxytocin-induced amygdala reactivity reduction in PTSD
    Study

    n = 37

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    40 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    In PTSD patients, greater anxiety prior to scanning and amygdala reactivity during the placebo session were associated with greater reduction of amygdala reactivity after OT administration.
    1 context sentence
    Summary · context
    As a first step to investigate the therapeutic potential of OT in PTSD, we conducted a double-blind, placebo-controlled, cross-over functional MRI study examining OT administration effects (40 IU) on amygdala reactivity toward emotional faces in unmedicated male and female police officers with (n=37…

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Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · 1 stopped early · source ClinicalTrials.gov (opens in a new tab)

TerminatedPhase 1/2NCT03863288

Dose Response Relationship of Oxytocin on Irritability in Youths

University of Nebraskan = 6018 Feb 2022 to 27 Feb 2024

Irritable Mood

Trial pageClinicalTrials.govUpdated 14 Mar 2025

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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