In lab tests at the human GnRH receptor, goserelin had a residence time of 5.6 min.
In plain wordsIn lab tests, goserelin remained bound to the human GnRH receptor for a residence time of 5.6 minutes.
- Peptide
- Goserelin
- Outcome
- Not applicableGnRH receptor residence time
- Study
humann: not reported in source
Human GnRH receptor binding assays- Outcome group
- Receptor activity and mechanism · Pharmacology
- Studied dose
- Dose not stated
Measurements
- Residence time
- 5.6 min
- goserelin
Source sentences
Interestingly, the binding kinetics of the peptide agonists were more divergent than their affinities with residence times ranging from 5.6 min (goserelin) to 125 min (deslorelin).
1 context sentence(design, population, supporting numbers)
A novel radioligand-binding competition association assay was developed and optimized for the human GnRH receptor with the use of a radiolabelled peptide agonist, [(125) I]-triptorelin.