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Study · Not a test of the peptide alone · 2015

2 results

Ghrelin alters neurite outgrowth and electrophysiological properties of mouse ventrolateral arcuate tyrosine hydroxylase neurons in culture.

Huang S, Lee SA, Oswald KE, Fry M

Biochemical and biophysical research communications15 Sept 2015Cited by 2 (Europe PMC)

PMID26385180 (opens in a new tab)DOI10.1016/j.bbrc.2015.09.069 (opens in a new tab)PepBankPUB-26385180
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

  1. 01LabNot a test of GHRP-6 aloneIn vitro (cells)Mechanism

    In mouse VL-ARC neuronal cultures, D-Lys-GHRP‑6 abolished the ghrelin-induced increase in neurite number.

    In plain wordsIn cells from mice, D-Lys-GHRP‑6 blocked the increase in neurite number seen with ghrelin alone.

    Peptide
    GHRP-6
    Outcome
    DecreaseNeurite number
    Study

    mousen: not reported in source

    VL-ARC TH-EGFP neuronal cultures
    Comparator
    ghrelin alone
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    After five days of treatment with 100 nM ghrelin, TH-EGFP neurons exhibited significantly more and longer neurites than control treated neurons, and the effects of ghrelin were abolished by 100 μM ghrelin antagonist, D-Lys-GHRP-6.
    1 context sentence
    Summary · context
    We prepared dissociated neuronal cultures from the VL-ARC of transgenic mice expressing EGFP under control of the tyrosine hydroxylase (TH) promoter, thus allowing visual identification of putative catecholaminergic (TH-EGFP) neurons.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  2. 02LabNot a test of GHRP-6 aloneIn vitro (cells)Mechanism

    In mouse VL-ARC neuronal cultures, D-Lys-GHRP‑6 abolished the ghrelin-induced increase in neurite length.

    In plain wordsIn cells from mice, D-Lys-GHRP‑6 blocked the increase in neurite length seen with ghrelin alone.

    Peptide
    GHRP-6
    Outcome
    DecreaseNeurite length
    Study

    mousen: not reported in source

    VL-ARC TH-EGFP neuronal cultures
    Comparator
    ghrelin alone
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    After five days of treatment with 100 nM ghrelin, TH-EGFP neurons exhibited significantly more and longer neurites than control treated neurons, and the effects of ghrelin were abolished by 100 μM ghrelin antagonist, D-Lys-GHRP-6.
    1 context sentence
    Summary · context
    We prepared dissociated neuronal cultures from the VL-ARC of transgenic mice expressing EGFP under control of the tyrosine hydroxylase (TH) promoter, thus allowing visual identification of putative catecholaminergic (TH-EGFP) neurons.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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