In recently trauma-exposed women, oxytocin increased left amygdala reactivity to neutral faces, as shown by a significant treatment by sex interaction.
In plain wordsIn recently trauma-exposed women, oxytocin raised left amygdala brain activity when viewing neutral faces compared with placebo, and the effect differed by sex.
- Peptide
- Oxytocin
- Outcome
- IncreaseLeft amygdala reactivity to neutral faces in women
- Study
n: not reported in source
- Comparator
- Placebo
- Analysis
- Exploratory
- Outcome group
- Brain and neuronal activity · Nervous system and cognition
- Studied dose
- 40 IU · intranasal · single doseAs given in this study (human).
Source sentences
There was a significant treatment by sex interaction on amygdala reactivity to neutral faces, with women showing increased left amygdala reactivity after oxytocin.
2 context sentences(design, population, supporting numbers)
We explored treatment interactions with sex.
In a randomized double-blind placebo-controlled fMRI study, we investigated effects of a single intranasal oxytocin administration (40 IU) on amygdala reactivity to happy, neutral and fearful faces in 41 recently trauma-exposed men and women showing moderate to high distress after initial post-trauma screening.