Skip to content

Study · Animal study (in vivo) · rat · 2015

3 results

Role of the Paraventricular Nucleus of the Hypothalamus in the Sympathoexcitatory Effects of Leptin.

Shi Z, Li B, Brooks VL

Hypertension (Dallas, Tex. : 1979)14 Sept 2015Cited by 49 (Europe PMC)

PMID26370892 (opens in a new tab)PMCIDPMC4798233 (opens in a new tab)DOI10.1161/hypertensionaha.115.06017 (opens in a new tab)PepBankPUB-26370892
Source linkPubMedAsk about this study
Jump to 3 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In anesthetized rats, melanotan II injected into the paraventricular nucleus increased lumbar sympathetic nerve activity only after blockade of neuropeptide Y Y1 receptors.

    In plain wordsIn anesthetized rats, melanotan II in a brain area raised sympathetic nerve activity, but only after neuropeptide Y receptors were blocked.

    Peptide
    Melanotan II
    Outcome
    IncreaseLumbar sympathetic nerve activity
    Study

    ratn: not reported in source

    Anesthetized male Sprague-Dawley rats
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    Dose not stated · intra-paraventricular nucleusAs given in this study (rat).

    Source sentences

    Summary
    Injection of the melanocortin 3/4 receptor agonist melanotan-II into the paraventricular nucleus increased LSNA, mean arterial pressure, and heart rate only after blockade of neuropeptide Y Y1 receptors.
    1 context sentence
    Summary · context
    Here, using anesthetized male Sprague-Dawley rats, we investigated the role of the paraventricular nucleus of the hypothalamus.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In anesthetized rats, melanotan II injected into the paraventricular nucleus increased mean arterial pressure only after blockade of neuropeptide Y Y1 receptors.

    In plain wordsIn anesthetized rats, melanotan II in a brain area raised blood pressure, but only after neuropeptide Y receptors were blocked.

    Peptide
    Melanotan II
    Outcome
    IncreaseMean arterial pressure
    Study

    ratn: not reported in source

    Anesthetized male Sprague-Dawley rats
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    Dose not stated · intra-paraventricular nucleusAs given in this study (rat).

    Source sentences

    Summary
    Injection of the melanocortin 3/4 receptor agonist melanotan-II into the paraventricular nucleus increased LSNA, mean arterial pressure, and heart rate only after blockade of neuropeptide Y Y1 receptors.
    1 context sentence
    Summary · context
    Here, using anesthetized male Sprague-Dawley rats, we investigated the role of the paraventricular nucleus of the hypothalamus.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In anesthetized rats, melanotan II injected into the paraventricular nucleus increased heart rate only after blockade of neuropeptide Y Y1 receptors.

    In plain wordsIn anesthetized rats, melanotan II in a brain area raised heart rate, but only after neuropeptide Y receptors were blocked.

    Peptide
    Melanotan II
    Outcome
    IncreaseHeart rate
    Study

    ratn: not reported in source

    Anesthetized male Sprague-Dawley rats
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated · intra-paraventricular nucleusAs given in this study (rat).

    Source sentences

    Summary
    Injection of the melanocortin 3/4 receptor agonist melanotan-II into the paraventricular nucleus increased LSNA, mean arterial pressure, and heart rate only after blockade of neuropeptide Y Y1 receptors.
    1 context sentence
    Summary · context
    Here, using anesthetized male Sprague-Dawley rats, we investigated the role of the paraventricular nucleus of the hypothalamus.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.