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Study · Other design · n = 70 · 2015

9 results

[Optimization of the treatment of anxiety disorders with selank].

Medvedev VE, Medvedev VE, Tereshchenko ON, Kost NV, Ter-Israelyan AY, Gushanskaya EV, Chobanu IK, Sokolov OY, Myasoedov NF

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova1 Jan 2015Cited by 1 (Europe PMC)

PMID26356395 (opens in a new tab)DOI10.17116/jnevro20151156133-40 (opens in a new tab)PepBankPUB-26356395
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. 9 results from people.

  1. 01HumanOther designEfficacy outcome

    In patients with anxiety disorders, adding selank to phenazepam brought the positive effect on HDRS earlier than phenazepam alone.

    In plain wordsIn patients with anxiety disorders, adding selank to phenazepam made the improvement on the HDRS scale come earlier than phenazepam alone.

    Peptide
    Selank
    Outcome
    DecreaseTime to positive effect on HDRS
    Study

    n = 70

    Comparator
    Phenazepam monotherapy
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The positive effect of phenazepam was achieved earlier in the optimization of treatment with selank on HDRS.
    1 context sentence
    Summary · context
    Authors explored the anxiolytic effect and tolerability of monotherapy with phenazepam (30 patients) and complex treatment with selank and phenazepam (40 patients) in anxiety-phobic, hypochondriac and somatoform disorders (ICD-10 items F40.2-9, F41.1-9, F45.0-2).
  2. 02HumanOther designSafety outcome

    In patients with anxiety disorders, adding selank reduced phenazepam-related attention and memory impairment compared with phenazepam alone.

    In plain wordsIn patients with anxiety disorders, adding selank reduced attention and memory problems caused by phenazepam, compared with phenazepam alone.

    Peptide
    Selank
    Outcome
    DecreaseAttention and memory impairment from phenazepam
    Study

    n = 70

    Comparator
    Phenazepam monotherapy
    Outcome group
    Adverse events · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The combined treatment decreased the level of undesirable side-effects of phenazepam (attention and memory impairment, asthenia, sedation, increase in sleep duration, sexual disturbances, emotional indifference and orthostatism) during the course of treatment and after the tranquilizer withdrawal.
    1 context sentence
    Summary · context
    Authors explored the anxiolytic effect and tolerability of monotherapy with phenazepam (30 patients) and complex treatment with selank and phenazepam (40 patients) in anxiety-phobic, hypochondriac and somatoform disorders (ICD-10 items F40.2-9, F41.1-9, F45.0-2).
  3. 03HumanOther designSafety outcome

    In patients with anxiety disorders, adding selank reduced phenazepam-related asthenia compared with phenazepam alone.

    In plain wordsIn patients with anxiety disorders, adding selank reduced weakness caused by phenazepam, compared with phenazepam alone.

    Peptide
    Selank
    Outcome
    DecreaseAsthenia from phenazepam
    Study

    n = 70

    Comparator
    Phenazepam monotherapy
    Outcome group
    Adverse events · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The combined treatment decreased the level of undesirable side-effects of phenazepam (attention and memory impairment, asthenia, sedation, increase in sleep duration, sexual disturbances, emotional indifference and orthostatism) during the course of treatment and after the tranquilizer withdrawal.
    1 context sentence
    Summary · context
    Authors explored the anxiolytic effect and tolerability of monotherapy with phenazepam (30 patients) and complex treatment with selank and phenazepam (40 patients) in anxiety-phobic, hypochondriac and somatoform disorders (ICD-10 items F40.2-9, F41.1-9, F45.0-2).
  4. 04HumanOther designSafety outcome

    In patients with anxiety disorders, adding selank reduced phenazepam-related sedation compared with phenazepam alone.

    In plain wordsIn patients with anxiety disorders, adding selank reduced sedation caused by phenazepam, compared with phenazepam alone.

    Peptide
    Selank
    Outcome
    DecreaseSedation from phenazepam
    Study

    n = 70

    Comparator
    Phenazepam monotherapy
    Outcome group
    Adverse events · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The combined treatment decreased the level of undesirable side-effects of phenazepam (attention and memory impairment, asthenia, sedation, increase in sleep duration, sexual disturbances, emotional indifference and orthostatism) during the course of treatment and after the tranquilizer withdrawal.
    1 context sentence
    Summary · context
    Authors explored the anxiolytic effect and tolerability of monotherapy with phenazepam (30 patients) and complex treatment with selank and phenazepam (40 patients) in anxiety-phobic, hypochondriac and somatoform disorders (ICD-10 items F40.2-9, F41.1-9, F45.0-2).
  5. 05HumanOther designSafety outcome

    In patients with anxiety disorders, adding selank reduced the phenazepam-related increase in sleep duration compared with phenazepam alone.

    In plain wordsIn patients with anxiety disorders, adding selank reduced the longer sleep caused by phenazepam, compared with phenazepam alone.

    Peptide
    Selank
    Outcome
    DecreaseIncrease in sleep duration from phenazepam
    Study

    n = 70

    Comparator
    Phenazepam monotherapy
    Outcome group
    Sleep · Sleep
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The combined treatment decreased the level of undesirable side-effects of phenazepam (attention and memory impairment, asthenia, sedation, increase in sleep duration, sexual disturbances, emotional indifference and orthostatism) during the course of treatment and after the tranquilizer withdrawal.
    1 context sentence
    Summary · context
    Authors explored the anxiolytic effect and tolerability of monotherapy with phenazepam (30 patients) and complex treatment with selank and phenazepam (40 patients) in anxiety-phobic, hypochondriac and somatoform disorders (ICD-10 items F40.2-9, F41.1-9, F45.0-2).
  6. 06HumanOther designSafety outcome

    In patients with anxiety disorders, adding selank reduced phenazepam-related sexual disturbances compared with phenazepam alone.

    In plain wordsIn patients with anxiety disorders, adding selank reduced sexual problems caused by phenazepam, compared with phenazepam alone.

    Peptide
    Selank
    Outcome
    DecreaseSexual disturbances from phenazepam
    Study

    n = 70

    Comparator
    Phenazepam monotherapy
    Outcome group
    Adverse events · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The combined treatment decreased the level of undesirable side-effects of phenazepam (attention and memory impairment, asthenia, sedation, increase in sleep duration, sexual disturbances, emotional indifference and orthostatism) during the course of treatment and after the tranquilizer withdrawal.
    1 context sentence
    Summary · context
    Authors explored the anxiolytic effect and tolerability of monotherapy with phenazepam (30 patients) and complex treatment with selank and phenazepam (40 patients) in anxiety-phobic, hypochondriac and somatoform disorders (ICD-10 items F40.2-9, F41.1-9, F45.0-2).
  7. 07HumanOther designSafety outcome

    In patients with anxiety disorders, adding selank reduced phenazepam-related emotional indifference compared with phenazepam alone.

    In plain wordsIn patients with anxiety disorders, adding selank reduced emotional indifference caused by phenazepam, compared with phenazepam alone.

    Peptide
    Selank
    Outcome
    DecreaseEmotional indifference from phenazepam
    Study

    n = 70

    Comparator
    Phenazepam monotherapy
    Outcome group
    Adverse events · Mental health and mood
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The combined treatment decreased the level of undesirable side-effects of phenazepam (attention and memory impairment, asthenia, sedation, increase in sleep duration, sexual disturbances, emotional indifference and orthostatism) during the course of treatment and after the tranquilizer withdrawal.
    1 context sentence
    Summary · context
    Authors explored the anxiolytic effect and tolerability of monotherapy with phenazepam (30 patients) and complex treatment with selank and phenazepam (40 patients) in anxiety-phobic, hypochondriac and somatoform disorders (ICD-10 items F40.2-9, F41.1-9, F45.0-2).
  8. 08HumanOther designSafety outcome

    In patients with anxiety disorders, adding selank reduced phenazepam-related orthostatism compared with phenazepam alone.

    In plain wordsIn patients with anxiety disorders, adding selank reduced orthostatism caused by phenazepam, compared with phenazepam alone.

    Peptide
    Selank
    Outcome
    DecreaseOrthostatism from phenazepam
    Study

    n = 70

    Comparator
    Phenazepam monotherapy
    Outcome group
    Adverse events · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The combined treatment decreased the level of undesirable side-effects of phenazepam (attention and memory impairment, asthenia, sedation, increase in sleep duration, sexual disturbances, emotional indifference and orthostatism) during the course of treatment and after the tranquilizer withdrawal.
    1 context sentence
    Summary · context
    Authors explored the anxiolytic effect and tolerability of monotherapy with phenazepam (30 patients) and complex treatment with selank and phenazepam (40 patients) in anxiety-phobic, hypochondriac and somatoform disorders (ICD-10 items F40.2-9, F41.1-9, F45.0-2).
  9. 09HumanOther designEfficacy outcome

    In patients with anxiety disorders, selank added to phenazepam had a positive impact on quality of life.

    In plain wordsIn patients with anxiety disorders, adding selank to phenazepam had a positive effect on quality of life.

    Peptide
    Selank
    Outcome
    IncreaseQuality of life (SF-36)
    Study

    n = 70

    Comparator
    Phenazepam monotherapy
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Taken together, the therapeutic efficacy and reduction of side-effects had a positive impact on the quality-of-life of the patients treated with selank as add-on to phenazepam.
    1 context sentence
    Summary · context
    Authors explored the anxiolytic effect and tolerability of monotherapy with phenazepam (30 patients) and complex treatment with selank and phenazepam (40 patients) in anxiety-phobic, hypochondriac and somatoform disorders (ICD-10 items F40.2-9, F41.1-9, F45.0-2).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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