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Study · Randomized controlled trial · 2015

3 results

[An assessment of cerebrolysin effect on BDNF level in patients with post stroke aphasia depending on carbohydrate metabolism disorders].

Shishkova VN, Zotova LI, Maljukova NG, Sutjusheva IR, Kan NV, Gasanova EM, Kerimova EI

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova1 Jan 2015Cited by 4 (Europe PMC)

PMID26356162 (opens in a new tab)DOI10.17116/jnevro20151155157-63 (opens in a new tab)PepBankPUB-26356162
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In patients with post-stroke aphasia, Cerebrolysin added to standard neurorehabilitation showed clinical efficacy for speech impairment.

    In plain wordsIn patients with post-stroke aphasia, Cerebrolysin added to standard rehabilitation improved speech impairment.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseSpeech recovery
    Study

    n: not reported in source

    Outcome group
    Speech and language · Nervous system and cognition
    Studied dose
    20 ml, 5 days a week · intravenous · 4 weeksAs given in this study (human).

    Source sentences

    Summary
    Clinical efficacy of cerebrolysin (intravenously in dose 20 ml in 100 ml of physiological solution, 5 days a week, during 4 weeks) used in addition to standard neurorehabilitation measures in patients with post stroke aphasia of different severity was demonstrated.
    1 context sentence
    Summary · context
    We carried out an open randomized controlled study to explore the changes in the rate of speech recovery and BDNF concentrations in patients with left-hemisphere stroke and carbohydrate metabolism disorders (diabetes mellitus type2 or prediabetes) who received cerebrolysin.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In post-stroke aphasia, Cerebrolysin treatment was most effective for very marked and marked speech impairment, particularly without carbohydrate metabolism disorders.

    In plain wordsIn post-stroke aphasia, Cerebrolysin improved speech most with very marked or marked impairment, particularly without carbohydrate metabolism disorders.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseSpeech improvement by severity and metabolic status
    Study

    n: not reported in source

    Outcome group
    Speech and language · Nervous system and cognition
    Studied dose
    20 ml, 5 days a week · intravenous · 4 weeksAs given in this study (human).

    Source sentences

    Summary
    This treatment was most effective in patients with very marked and marked speech impairment that was confirmed by the maximal possible improvement of speech during the first course of neurorehabilitation measures, in particular in a subgroup of patients without carbohydrate metabolism disorders.
    1 context sentence
    Summary · context
    We carried out an open randomized controlled study to explore the changes in the rate of speech recovery and BDNF concentrations in patients with left-hemisphere stroke and carbohydrate metabolism disorders (diabetes mellitus type2 or prediabetes) who received cerebrolysin.
  3. 03HumanRandomized controlled trialMechanism

    In patients with post-stroke aphasia, Cerebrolysin treatment significantly increased BDNF concentrations.

    In plain wordsIn patients with post-stroke aphasia, Cerebrolysin treatment increased BDNF concentrations.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseBDNF concentration
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    20 ml, 5 days a week · intravenous · 4 weeksAs given in this study (human).

    Source sentences

    Summary
    A significant increase in BDNF concentrations was an additional evidence of this improvement.
    2 context sentences
    Summary · context
    Clinical efficacy of cerebrolysin (intravenously in dose 20 ml in 100 ml of physiological solution, 5 days a week, during 4 weeks) used in addition to standard neurorehabilitation measures in patients with post stroke aphasia of different severity was demonstrated.
    Summary · context
    We carried out an open randomized controlled study to explore the changes in the rate of speech recovery and BDNF concentrations in patients with left-hemisphere stroke and carbohydrate metabolism disorders (diabetes mellitus type2 or prediabetes) who received cerebrolysin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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