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Study · Randomized controlled trial · n = 37 · 2016

5 results

Intranasal Oxytocin Affects Amygdala Functional Connectivity after Trauma Script-Driven Imagery in Distressed Recently Trauma-Exposed Individuals.

Frijling JL, van Zuiden M, Koch SB, Nawijn L, Veltman DJ, Olff M

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology31 Aug 2015Cited by 53 (Europe PMC)

PMID26346640 (opens in a new tab)PMCIDPMC4793112 (opens in a new tab)DOI10.1038/npp.2015.278 (opens in a new tab)PepBankPUB-26346640
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

  1. 01HumanRandomized controlled trialMechanism

    In recently trauma-exposed individuals, oxytocin reduced amygdala-left vlPFC functional connectivity after trauma script-driven imagery versus neutral imagery, whereas placebo enhanced it.

    In plain wordsIn recently trauma-exposed people, oxytocin lowered a measure of amygdala-prefrontal brain connectivity after trauma reminders, while placebo raised it.

    Peptide
    Oxytocin
    Outcome
    DecreaseAmygdala-left vlPFC functional connectivity after trauma script
    Study

    n = 37

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    40 IU · intranasal · single doseAs given in this study (human).

    Source sentences

    Summary
    We found that oxytocin administration reduced amygdala-left vlPFC FC after trauma script-driven imagery, compared with neutral script-driven imagery, whereas in PL-treated participants enhanced amygdala-left vlPFC FC was observed following trauma script-driven imagery.
    1 context sentence
    Summary · context
    a single intranasal oxytocin administration (40 IU) on seed-based amygdala resting-state FC with emotion regulation areas (ventromedial prefrontal cortex (vmPFC), ventrolateral prefrontal cortex (vlPFC)), and salience processing areas (insula, dorsal anterior cingulate cortex (dACC)) in 37 individua…
  2. 02HumanRandomized controlled trialMechanism

    In recently trauma-exposed individuals, oxytocin increased amygdala-insula functional connectivity irrespective of script condition.

    In plain wordsIn recently trauma-exposed people, oxytocin raised amygdala-insula brain connectivity compared with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseAmygdala-insula functional connectivity
    Study

    n = 37

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    40 IU · intranasal · single doseAs given in this study (human).

    Source sentences

    Summary
    Irrespective of script condition, oxytocin increased amygdala-insula FC and decreased amygdala-vmPFC FC.
    1 context sentence
    Summary · context
    a single intranasal oxytocin administration (40 IU) on seed-based amygdala resting-state FC with emotion regulation areas (ventromedial prefrontal cortex (vmPFC), ventrolateral prefrontal cortex (vlPFC)), and salience processing areas (insula, dorsal anterior cingulate cortex (dACC)) in 37 individua…
  3. 03HumanRandomized controlled trialMechanism

    In recently trauma-exposed individuals, oxytocin decreased amygdala-vmPFC functional connectivity irrespective of script condition.

    In plain wordsIn recently trauma-exposed people, oxytocin lowered amygdala-prefrontal brain connectivity compared with placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseAmygdala-vmPFC functional connectivity
    Study

    n = 37

    Comparator
    Placebo
    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    40 IU · intranasal · single doseAs given in this study (human).

    Source sentences

    Summary
    Irrespective of script condition, oxytocin increased amygdala-insula FC and decreased amygdala-vmPFC FC.
    1 context sentence
    Summary · context
    a single intranasal oxytocin administration (40 IU) on seed-based amygdala resting-state FC with emotion regulation areas (ventromedial prefrontal cortex (vmPFC), ventrolateral prefrontal cortex (vlPFC)), and salience processing areas (insula, dorsal anterior cingulate cortex (dACC)) in 37 individua…
  4. 04HumanRandomized controlled trialEfficacy outcome

    In recently trauma-exposed individuals, the oxytocin group reported lower sleepiness after the trauma script than the placebo group.

    In plain wordsIn recently trauma-exposed people, those given oxytocin felt less sleepy after trauma reminders than those given placebo.

    Peptide
    Oxytocin
    Outcome
    DecreaseSleepiness after trauma script
    Study

    n = 37

    Comparator
    Placebo
    Outcome group
    Sleep · Sleep
    Studied dose
    40 IU · intranasal · single doseAs given in this study (human).

    Source sentences

    Summary
    These neural effects were accompanied by lower levels of sleepiness and higher flashback intensity in the oxytocin group after the trauma script.
    1 context sentence
    Summary · context
    a single intranasal oxytocin administration (40 IU) on seed-based amygdala resting-state FC with emotion regulation areas (ventromedial prefrontal cortex (vmPFC), ventrolateral prefrontal cortex (vlPFC)), and salience processing areas (insula, dorsal anterior cingulate cortex (dACC)) in 37 individua…
  5. 05HumanRandomized controlled trialEfficacy outcome

    In recently trauma-exposed individuals, the oxytocin group reported higher flashback intensity after the trauma script than the placebo group.

    In plain wordsIn recently trauma-exposed people, those given oxytocin reported more intense flashbacks after trauma reminders than those given placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseFlashback intensity after trauma script
    Study

    n = 37

    Comparator
    Placebo
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    40 IU · intranasal · single doseAs given in this study (human).

    Source sentences

    Summary
    These neural effects were accompanied by lower levels of sleepiness and higher flashback intensity in the oxytocin group after the trauma script.
    1 context sentence
    Summary · context
    a single intranasal oxytocin administration (40 IU) on seed-based amygdala resting-state FC with emotion regulation areas (ventromedial prefrontal cortex (vmPFC), ventrolateral prefrontal cortex (vlPFC)), and salience processing areas (insula, dorsal anterior cingulate cortex (dACC)) in 37 individua…

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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