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Study · Measured the body's own peptide · 2016

2 results

Acute Response of PGC-1α and IGF-1 Isoforms to Maximal Eccentric Exercise in Skeletal Muscle of Postmenopausal Women.

Dieli-Conwright CM, Kiwata JL, Tuzon CT, Spektor TM, Sattler FR, Rice JC, Schroeder ET

Journal of strength and conditioning research1 Apr 2016Cited by 9 (Europe PMC)

PMID26340467 (opens in a new tab)PMCIDPMC4769997 (opens in a new tab)DOI10.1519/jsc.0000000000001171 (opens in a new tab)PepBankPUB-26340467
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelNon-randomized trialMechanism

    In postmenopausal women, the body's own MGF mRNA did not change significantly 4 hours after maximal eccentric exercise.

    In plain wordsIn postmenopausal women, the body's own MGF gene activity in muscle did not change after a hard exercise bout.

    Peptide
    MGF / PEG-MGF
    Outcome
    No significant changeMGF mRNA expression 4 hours after eccentric exercise
    Study

    n = 9

    Comparator
    Pre-exercise
    Outcome group
    Exercise and physical function · Musculoskeletal

    Source sentences

    Summary
    whereas IGF-1Eb and mechano-growth factor (MGF) did not significantly change (p > 0.05).
    2 context sentences
    Summary · context
    Nine postmenopausal women (age, 57.9 ± 3.2 years) performed 10 sets of 10 maximal eccentric repetitions of single-leg extension with 20-second rest periods between sets.
    Summary · context
    Muscle biopsies were obtained from the vastus lateralis of the exercised leg before and 4 hours after the RE bout with mRNA expression determined by quantitative real-time polymerase chain reaction.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelNon-randomized trialMechanism

    In postmenopausal women after eccentric exercise, MGF mRNA expression was associated with reduced mRNA expression of the catabolic gene FOXO3A.

    In plain wordsIn postmenopausal women, higher body's own MGF gene activity was linked to lower activity of the muscle-breakdown gene FOXO3A.

    Peptide
    MGF / PEG-MGF
    Outcome
    Not applicableAssociation of MGF mRNA with FOXO3A mRNA
    Study

    n = 9

    Outcome group
    Exercise and physical function · Musculoskeletal

    Measurements

    correlation R
    −0.81 R
    MGF vs FOXO3A mRNA

    Source sentences

    Summary
    whereas MGF mRNA expression was associated with reduced mRNA expression of the catabolic gene FOXO3A (R = -0.81, p ≤ 0.05).
    2 context sentences
    Summary · context
    Nine postmenopausal women (age, 57.9 ± 3.2 years) performed 10 sets of 10 maximal eccentric repetitions of single-leg extension with 20-second rest periods between sets.
    Summary · context
    Muscle biopsies were obtained from the vastus lateralis of the exercised leg before and 4 hours after the RE bout with mRNA expression determined by quantitative real-time polymerase chain reaction.

    This result measures the body's own MGF / PEG-MGF. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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