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Study · In vitro (cells) · 2015

6 results

Mechano growth factor-E regulates apoptosis and inflammatory responses in fibroblast-like synoviocytes of knee osteoarthritis.

Li H, Lei M, Yu C, Lv Y, Song Y, Yang L

International orthopaedics4 Sept 2015Cited by 12 (Europe PMC)

PMID26338342 (opens in a new tab)DOI10.1007/s00264-015-2974-5 (opens in a new tab)PepBankPUB-26338342
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Safety outcome

    In osteoarthritis fibroblast-like synoviocytes, exogenous MGF-E peptide had no obvious cytotoxic effects.

    In plain wordsIn cells, the MGF-E peptide did not clearly harm joint lining cells.

    Peptide
    MGF / PEG-MGF
    Outcome
    No significant changeCytotoxicity in OA-FLS
    Study

    n: not reported in source

    OA fibroblast-like synoviocytes (OA-FLS)
    Outcome group
    Cell viability and death · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Exogenous MGF-E peptide has no obvious cytotoxic effects on OA-FLS and promotes LOX expression in OA-FLS, induce apoptosis and ER stress and down-regulate protein levels of tumour necrosis factor alpha (TNF-α) and interleukin-1 beta (IL-1β).
    1 context sentence
    Summary · context
    A (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium, inner salt) (MTS) assay was performed to evaluate cytotoxic effects of exogenous MGF-E peptide on OA fibroblast-like synoviocytes (OA-FLS).
  2. 02LabIn vitro (cells)Mechanism

    In osteoarthritis fibroblast-like synoviocytes, exogenous MGF-E peptide promoted LOX expression.

    In plain wordsIn cells, the MGF-E peptide raised the activity of the LOX gene in joint lining cells.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseLOX expression
    Study

    n: not reported in source

    OA fibroblast-like synoviocytes (OA-FLS)
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Exogenous MGF-E peptide has no obvious cytotoxic effects on OA-FLS and promotes LOX expression in OA-FLS, induce apoptosis and ER stress and down-regulate protein levels of tumour necrosis factor alpha (TNF-α) and interleukin-1 beta (IL-1β).
    1 context sentence
    Summary · context
    Quantitative real-time polymerase chain reaction (qRT-PCR) was used to check messenger RNA (mRNA) expression levels of lysyl oxidase (LOX) family members (LOX) after OA-FLS treatment using MGF-E peptide.
  3. 03LabIn vitro (cells)Mechanism

    In osteoarthritis fibroblast-like synoviocytes, exogenous MGF-E peptide induced apoptosis.

    In plain wordsIn cells, the MGF-E peptide caused more programmed cell death in joint lining cells.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseApoptosis
    Study

    n: not reported in source

    OA fibroblast-like synoviocytes (OA-FLS)
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Exogenous MGF-E peptide has no obvious cytotoxic effects on OA-FLS and promotes LOX expression in OA-FLS, induce apoptosis and ER stress and down-regulate protein levels of tumour necrosis factor alpha (TNF-α) and interleukin-1 beta (IL-1β).
  4. 04LabIn vitro (cells)Mechanism

    In osteoarthritis fibroblast-like synoviocytes, exogenous MGF-E peptide induced endoplasmic reticulum (ER) stress.

    In plain wordsIn cells, the MGF-E peptide caused more stress in a part of the cell called the ER.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseER stress
    Study

    n: not reported in source

    OA fibroblast-like synoviocytes (OA-FLS)
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Exogenous MGF-E peptide has no obvious cytotoxic effects on OA-FLS and promotes LOX expression in OA-FLS, induce apoptosis and ER stress and down-regulate protein levels of tumour necrosis factor alpha (TNF-α) and interleukin-1 beta (IL-1β).
    1 context sentence
    Summary · context
    Western blot was used to detect biomarkers of endoplasmic reticulum (ER) stress and inflammatory cytokines.
  5. 05LabIn vitro (cells)Mechanism

    In osteoarthritis fibroblast-like synoviocytes, exogenous MGF-E peptide down-regulated protein levels of TNF-α.

    In plain wordsIn cells, the MGF-E peptide lowered TNF-α, an inflammation signal, in joint lining cells.

    Peptide
    MGF / PEG-MGF
    Outcome
    DecreaseTNF-α protein level
    Study

    n: not reported in source

    OA fibroblast-like synoviocytes (OA-FLS)
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Exogenous MGF-E peptide has no obvious cytotoxic effects on OA-FLS and promotes LOX expression in OA-FLS, induce apoptosis and ER stress and down-regulate protein levels of tumour necrosis factor alpha (TNF-α) and interleukin-1 beta (IL-1β).
    1 context sentence
    Summary · context
    Western blot was used to detect biomarkers of endoplasmic reticulum (ER) stress and inflammatory cytokines.
  6. 06LabIn vitro (cells)Mechanism

    In osteoarthritis fibroblast-like synoviocytes, exogenous MGF-E peptide down-regulated protein levels of IL-1β.

    In plain wordsIn cells, the MGF-E peptide lowered IL-1β, an inflammation signal, in joint lining cells.

    Peptide
    MGF / PEG-MGF
    Outcome
    DecreaseIL-1β protein level
    Study

    n: not reported in source

    OA fibroblast-like synoviocytes (OA-FLS)
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Exogenous MGF-E peptide has no obvious cytotoxic effects on OA-FLS and promotes LOX expression in OA-FLS, induce apoptosis and ER stress and down-regulate protein levels of tumour necrosis factor alpha (TNF-α) and interleukin-1 beta (IL-1β).
    1 context sentence
    Summary · context
    Western blot was used to detect biomarkers of endoplasmic reticulum (ER) stress and inflammatory cytokines.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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