Mechano-growth factor enhances differentiation of bone marrow-derived mesenchymal stem cells.

Li H, Lei M, Luo Z, Wu S, Zhong L, Xu Z, Lv Y, Yang L

Biotechnology letters2 Sept 2015Cited by 10 (Europe PMC)

PMID26330369DOI10.1007/s10529-015-1915-0PepBankPUB-26330369

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

5 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Efficacy outcome
In human bone marrow-derived mesenchymal stem cells, MGF E peptide significantly increased osteogenic differentiation.
In plain wordsIn cells, the MGF E peptide made human bone marrow stem cells turn into bone cells more.
Peptide
MGF / PEG-MGF
Outcome
IncreaseOsteogenic differentiation of hBMSCs
Study
humann: not reported in source
human bone marrow-derived mesenchymal stem cells (hBMSCs) in vitro
Outcome group
Cell proliferation and differentiation · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
Alizarin Red S, Oil Red O and Alcian Blue staining showed osteogenic, adipogenic and chondrogenic differentiation were significantly increased after hBMSCs were treated with MGF E peptide.
1 context sentence(design, population, supporting numbers)
Summary · context
To investigate the effect of mechano-growth factor (MGF) on the differentiation of human bone marrow-derived mesenchymal stem cells (hBMSCs) in vitro.
Report a problemFND-2633036901
02LabIn vitro (cells)Efficacy outcome
In human bone marrow-derived mesenchymal stem cells, MGF E peptide significantly increased adipogenic differentiation.
In plain wordsIn cells, the MGF E peptide made human bone marrow stem cells turn into fat cells more.
Peptide
MGF / PEG-MGF
Outcome
IncreaseAdipogenic differentiation of hBMSCs
Study
humann: not reported in source
human bone marrow-derived mesenchymal stem cells (hBMSCs) in vitro
Outcome group
Cell proliferation and differentiation · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
Alizarin Red S, Oil Red O and Alcian Blue staining showed osteogenic, adipogenic and chondrogenic differentiation were significantly increased after hBMSCs were treated with MGF E peptide.
1 context sentence(design, population, supporting numbers)
Summary · context
To investigate the effect of mechano-growth factor (MGF) on the differentiation of human bone marrow-derived mesenchymal stem cells (hBMSCs) in vitro.
Report a problemFND-2633036902
03LabIn vitro (cells)Efficacy outcome
In human bone marrow-derived mesenchymal stem cells, MGF E peptide significantly increased chondrogenic differentiation.
In plain wordsIn cells, the MGF E peptide made human bone marrow stem cells turn into cartilage cells more.
Peptide
MGF / PEG-MGF
Outcome
IncreaseChondrogenic differentiation of hBMSCs
Study
humann: not reported in source
human bone marrow-derived mesenchymal stem cells (hBMSCs) in vitro
Outcome group
Cell proliferation and differentiation · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
Alizarin Red S, Oil Red O and Alcian Blue staining showed osteogenic, adipogenic and chondrogenic differentiation were significantly increased after hBMSCs were treated with MGF E peptide.
1 context sentence(design, population, supporting numbers)
Summary · context
To investigate the effect of mechano-growth factor (MGF) on the differentiation of human bone marrow-derived mesenchymal stem cells (hBMSCs) in vitro.
Report a problemFND-2633036903
04LabIn vitro (cells)Mechanism
In hBMSCs, the proliferation rate was decreased after MGF treatment compared with the control group.
In plain wordsIn cells, MGF treatment slowed the growth of human bone marrow stem cells compared with untreated cells.
Peptide
MGF / PEG-MGF
Outcome
DecreasehBMSC proliferation rate
Study
humann: not reported in source
human bone marrow-derived mesenchymal stem cells (hBMSCs) in vitro
Comparator
Control group
Outcome group
Cell proliferation and differentiation · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
hBMSCs proliferation rate was decreased and G1 phase of the cell cycle was lengthened after MGF treatment when compared to the control group.
1 context sentence(design, population, supporting numbers)
Summary · context
To investigate the effect of mechano-growth factor (MGF) on the differentiation of human bone marrow-derived mesenchymal stem cells (hBMSCs) in vitro.
Report a problemFND-2633036906
05LabIn vitro (cells)Mechanism
In hBMSCs, the G1 phase of the cell cycle was lengthened after MGF treatment compared with the control group.
In plain wordsIn cells, MGF treatment lengthened one phase of the cell cycle compared with untreated cells.
Peptide
MGF / PEG-MGF
Outcome
IncreaseG1 phase length of the cell cycle
Study
humann: not reported in source
human bone marrow-derived mesenchymal stem cells (hBMSCs) in vitro
Comparator
Control group
Outcome group
Cell proliferation and differentiation · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
G1 phase of the cell cycle was lengthened after MGF treatment when compared to the control group.
1 context sentence(design, population, supporting numbers)
Summary · context
To investigate the effect of mechano-growth factor (MGF) on the differentiation of human bone marrow-derived mesenchymal stem cells (hBMSCs) in vitro.
Report a problemFND-2633036907

Studies that did not test the peptide alone2

In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking MGF / PEG-MGF.

06LabNot a test of MGF / PEG-MGF aloneIn vitro (cells)Efficacy outcome
In hBMSCs, Collagen II expression was considerably increased with chondrogenic medium supplemented with TGF-β3 and MGF E peptide. The abstract names no comparator without the peptide.
In plain wordsIn cells, Collagen II rose with TGF-β3 and MGF E peptide together. The abstract does not show the effect of the peptide alone.
Peptide
MGF / PEG-MGF
Outcome
IncreaseCollagen II expression with TGF-β3 and MGF E peptide
Study
humann: not reported in source
human bone marrow-derived mesenchymal stem cells (hBMSCs) in vitro
Outcome group
Cell proliferation and differentiation · Musculoskeletal
Source sentences
Summary
Collagen II expression was considerably increased after hBMSCs were induced with chondrogenic induction culture medium supplemented with TGF-β3 and MGF E peptide.
1 context sentence(design, population, supporting numbers)
Summary · context
To investigate the effect of mechano-growth factor (MGF) on the differentiation of human bone marrow-derived mesenchymal stem cells (hBMSCs) in vitro.
In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.
Report a problemFND-2633036904
07LabNot a test of MGF / PEG-MGF aloneIn vitro (cells)Efficacy outcome
In hBMSCs, overexpression of MGF by an expression plasmid enhanced tri-lineage differentiation.
In plain wordsIn cells, adding an MGF gene on a plasmid increased how much stem cells turned into three cell types.
Peptide
MGF / PEG-MGF
Outcome
IncreaseTri-lineage differentiation after MGF overexpression by plasmid
Study
humann: not reported in source
human bone marrow-derived mesenchymal stem cells (hBMSCs) in vitro
Outcome group
Cell proliferation and differentiation · Musculoskeletal
Source sentences
Summary
Overexpression of MGF by an expression plasmid further confirmed the MGF could enhance tri-lineage differentiation of hBMSCs.
1 context sentence(design, population, supporting numbers)
Summary · context
To investigate the effect of mechano-growth factor (MGF) on the differentiation of human bone marrow-derived mesenchymal stem cells (hBMSCs) in vitro.
In this study, MGF / PEG-MGF was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MGF / PEG-MGF.
Report a problemFND-2633036905

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

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