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Study · Animal study (in vivo) · rat · 2015

7 results

Efficacy of thymosin α1 and interferon α for the treatment of severe acute pancreatitis in a rat model.

Wang X, Zeng X, Yang B, Zhao S, Chen W, Guo X

Molecular medicine reports1 Sept 2015Cited by 7 (Europe PMC)

PMID26330363 (opens in a new tab)PMCIDPMC4626153 (opens in a new tab)DOI10.3892/mmr.2015.4277 (opens in a new tab)PepBankPUB-26330363
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with severe acute pancreatitis, thymosin alpha‑1 reduced mortality from 50.0% (6/12) to 25.0% (3/12).

    In plain wordsIn rats with severe pancreatitis, fewer rats died with thymosin alpha‑1 than without treatment.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseMortality
    Study

    ratn = 24

    Severe acute pancreatitis induced by sodium taurocholate
    Comparator
    SAP group (saline)
    Outcome group
    Mortality · Whole body
    Studied dose
    26.7 µg/kgAs given in this study (rat).

    Measurements

    Mortality
    25%
    TA1 group
    Mortality
    50%
    SAP group

    Source sentences

    Summary
    mortality rates were reduced from 50.0% (6/12) to 25.0% (3/12) and 33.3% (4/12), respectively.
    2 context sentences
    Summary · context
    The three other groups were administered with 5% 1 ml/kg sodium taurocholate via the cholangiopancreatic duct.
    Summary · context
    SAP group rats were administered with an intravenous injection of saline; TA1 group rats received 26.7 µg/kg TA1; and interferon α (INFα) group rats received 4.0x105 U/kg IFNα.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with severe acute pancreatitis, thymosin alpha‑1 lowered aspartate transaminase, lactate dehydrogenase, amylase and lipase compared with untreated pancreatitis rats within 24 hours.

    In plain wordsIn rats with severe pancreatitis, thymosin alpha‑1 lowered blood enzyme markers of damage compared with untreated rats.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseSerum enzyme indicators (AST, LDH, amylase, lipase)
    Study

    ratn: not reported in source

    Severe acute pancreatitis induced by sodium taurocholate
    Comparator
    SAP group (saline)
    Outcome group
    Organ injury · Gastrointestinal
    Studied dose
    26.7 µg/kgAs given in this study (rat).

    Source sentences

    Summary
    The expression levels of aspartate transaminase, lactate dehydrogenase, α‑amylase (AMY), P‑type‑amylase, lipase, PCT, tumor‑necrosis factor α, interleukin (IL)‑4, IL‑5, and IL‑18 in the TA1 and IFNα‑treated rats were significantly lower, compared with those of the SAP rats within the first 24 h of m…
    2 context sentences
    Summary · context
    The three other groups were administered with 5% 1 ml/kg sodium taurocholate via the cholangiopancreatic duct.
    Summary · context
    SAP group rats were administered with an intravenous injection of saline; TA1 group rats received 26.7 µg/kg TA1; and interferon α (INFα) group rats received 4.0x105 U/kg IFNα.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with severe acute pancreatitis, thymosin alpha‑1 lowered procalcitonin compared with untreated pancreatitis rats within 24 hours.

    In plain wordsIn rats with severe pancreatitis, thymosin alpha‑1 lowered procalcitonin, an inflammation marker, compared with untreated rats.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseProcalcitonin
    Study

    ratn: not reported in source

    Severe acute pancreatitis induced by sodium taurocholate
    Comparator
    SAP group (saline)
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    26.7 µg/kgAs given in this study (rat).

    Source sentences

    Summary
    The expression levels of aspartate transaminase, lactate dehydrogenase, α‑amylase (AMY), P‑type‑amylase, lipase, PCT, tumor‑necrosis factor α, interleukin (IL)‑4, IL‑5, and IL‑18 in the TA1 and IFNα‑treated rats were significantly lower, compared with those of the SAP rats within the first 24 h of m…
    2 context sentences
    Summary · context
    The three other groups were administered with 5% 1 ml/kg sodium taurocholate via the cholangiopancreatic duct.
    Summary · context
    SAP group rats were administered with an intravenous injection of saline; TA1 group rats received 26.7 µg/kg TA1; and interferon α (INFα) group rats received 4.0x105 U/kg IFNα.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with severe acute pancreatitis, thymosin alpha‑1 lowered tumor necrosis factor α, IL-4, IL-5 and IL-18 compared with untreated pancreatitis rats within 24 hours.

    In plain wordsIn rats with severe pancreatitis, thymosin alpha‑1 lowered several inflammation signals compared with untreated rats.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseCytokines (TNF-α, IL-4, IL-5, IL-18)
    Study

    ratn: not reported in source

    Severe acute pancreatitis induced by sodium taurocholate
    Comparator
    SAP group (saline)
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    26.7 µg/kgAs given in this study (rat).

    Source sentences

    Summary
    The expression levels of aspartate transaminase, lactate dehydrogenase, α‑amylase (AMY), P‑type‑amylase, lipase, PCT, tumor‑necrosis factor α, interleukin (IL)‑4, IL‑5, and IL‑18 in the TA1 and IFNα‑treated rats were significantly lower, compared with those of the SAP rats within the first 24 h of m…
    2 context sentences
    Summary · context
    The three other groups were administered with 5% 1 ml/kg sodium taurocholate via the cholangiopancreatic duct.
    Summary · context
    SAP group rats were administered with an intravenous injection of saline; TA1 group rats received 26.7 µg/kg TA1; and interferon α (INFα) group rats received 4.0x105 U/kg IFNα.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats with severe acute pancreatitis, thymosin alpha‑1 significantly increased CD3+, CD4+ and CD8+ T cell levels compared with untreated pancreatitis rats.

    In plain wordsIn rats with severe pancreatitis, thymosin alpha‑1 raised T cell levels compared with untreated rats.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseCD3+, CD4+ and CD8+ T cell levels
    Study

    ratn: not reported in source

    Severe acute pancreatitis induced by sodium taurocholate
    Comparator
    SAP group (saline)
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    26.7 µg/kgAs given in this study (rat).

    Source sentences

    Summary
    The TA1 and IFNα‑treated rats exhibited significantly increased levels of CD3+, CD4+ and CD8+ T cells, and an increased ratio of CD4+/CD8+ cells, compared with SAP rats.
    2 context sentences
    Summary · context
    The three other groups were administered with 5% 1 ml/kg sodium taurocholate via the cholangiopancreatic duct.
    Summary · context
    SAP group rats were administered with an intravenous injection of saline; TA1 group rats received 26.7 µg/kg TA1; and interferon α (INFα) group rats received 4.0x105 U/kg IFNα.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats with severe acute pancreatitis, thymosin alpha‑1 increased the CD4+/CD8+ ratio compared with untreated pancreatitis rats.

    In plain wordsIn rats with severe pancreatitis, thymosin alpha‑1 raised the CD4+/CD8+ T cell ratio compared with untreated rats.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseCD4+/CD8+ ratio
    Study

    ratn: not reported in source

    Severe acute pancreatitis induced by sodium taurocholate
    Comparator
    SAP group (saline)
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    26.7 µg/kgAs given in this study (rat).

    Source sentences

    Summary
    The TA1 and IFNα‑treated rats exhibited significantly increased levels of CD3+, CD4+ and CD8+ T cells, and an increased ratio of CD4+/CD8+ cells, compared with SAP rats.
    2 context sentences
    Summary · context
    The three other groups were administered with 5% 1 ml/kg sodium taurocholate via the cholangiopancreatic duct.
    Summary · context
    SAP group rats were administered with an intravenous injection of saline; TA1 group rats received 26.7 µg/kg TA1; and interferon α (INFα) group rats received 4.0x105 U/kg IFNα.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In rats with severe acute pancreatitis, thymosin alpha‑1 significantly reduced pancreas and lung damage on histology compared with untreated pancreatitis rats.

    In plain wordsIn rats with severe pancreatitis, thymosin alpha‑1 reduced damage to the pancreas and lungs compared with untreated rats.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreasePancreas and lung histology
    Study

    ratn: not reported in source

    Severe acute pancreatitis induced by sodium taurocholate
    Comparator
    SAP group (saline)
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    26.7 µg/kgAs given in this study (rat).

    Source sentences

    Summary
    Histological analysis revealed that the TA1 and IFNα‑treated rats exhibited significantly ameliorated pancreas and lung damage
    2 context sentences
    Summary · context
    The three other groups were administered with 5% 1 ml/kg sodium taurocholate via the cholangiopancreatic duct.
    Summary · context
    SAP group rats were administered with an intravenous injection of saline; TA1 group rats received 26.7 µg/kg TA1; and interferon α (INFα) group rats received 4.0x105 U/kg IFNα.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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