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Study · Animal study (in vivo) · rat · 2015

2 results

The effectiveness of different neuroprotective agents in facial nerve injury: An experimental study.

Tanyeri G, Celik O, Erbas O, Oltulu F, Yilmaz Dilsiz O

The Laryngoscope26 Aug 2015Cited by 21 (Europe PMC)

PMID26308241 (opens in a new tab)DOI10.1002/lary.25554 (opens in a new tab)PepBankPUB-26308241
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with facial nerve crush injury, oxytocin significantly increased peak-to-peak amplitude on facial electromyography (P=0.004).

    In plain wordsIn rats with a crushed facial nerve, oxytocin increased the strength of the nerve-muscle signal.

    Peptide
    Oxytocin
    Outcome
    IncreasePeak-to-peak amplitude on facial electromyography
    Study

    ratn: not reported in source

    Facial nerve crush injury
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitoneal · 28 daysAs given in this study (rat).

    Source sentences

    Summary
    In peak-to-peak amplitude values, a significant increase was observed in the dexamethasone (P=0.007) and oxytocin subgroups (P=0.004) and was even more apparent in the resveratrol subgroup (P<0.001).
    2 context sentences
    Summary · context
    A crush-type facial nerve injury was performed on the right side of all rats (injury group [IG]), whereas there was no injury on the left side (sham group [SG]).
    Summary · context
    These main groups were divided into five subgroups: 1) no medicine (control); 2) physiological serum; 3) dexamethasone; 4) oxytocin; and 5) resveratrol (Res) administered (intraperitoneal injection) for 28 days.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats with facial nerve crush injury, caspase 3 and 6 immunoexpression in the oxytocin subgroup was moderate compared with the dexamethasone subgroup.

    In plain wordsIn rats with a crushed facial nerve, oxytocin-treated animals showed moderate cell-death markers compared with dexamethasone-treated animals.

    Peptide
    Oxytocin
    Outcome
    Direction not reportedCaspase 3 and 6 immunoexpression
    Study

    ratn: not reported in source

    Facial nerve crush injury
    Comparator
    Dexamethasone
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitoneal · 28 daysAs given in this study (rat).

    Source sentences

    Summary
    Caspase 3 and 6 immunoexpressions of resveratrol and oxytocin subgroups were moderate when compared with dexamethasone subgroup.
    2 context sentences
    Summary · context
    A crush-type facial nerve injury was performed on the right side of all rats (injury group [IG]), whereas there was no injury on the left side (sham group [SG]).
    Summary · context
    These main groups were divided into five subgroups: 1) no medicine (control); 2) physiological serum; 3) dexamethasone; 4) oxytocin; and 5) resveratrol (Res) administered (intraperitoneal injection) for 28 days.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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