Effect of Intra-articular Injection of AOD9604 with or without Hyaluronic Acid in Rabbit Osteoarthritis Model.

Kwon DR, Park GY

Annals of clinical and laboratory science1 Jan 2015Cited by 9 (Europe PMC)

PMID26275694PepBankPUB-26275694

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study12

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rabbits with collagenase-induced knee osteoarthritis, gross morphological scores were significantly lower with AOD9604 alone than with saline.
In plain wordsIn rabbits with knee arthritis, joint damage scores were lower with AOD9604 than with saline.
Peptide
AOD-9604
Outcome
DecreaseGross morphological score
Study
rabbitn: not reported in source
collagenase-induced knee osteoarthritis
Comparator
Saline (Group 1)
Outcome group
Bone and joint · Musculoskeletal
Studied dose
0.25 mg AOD9604 weekly · intra-articular · 4-7 weeksAs given in this study (rabbit).
Source sentences
Summary
Mean gross morphological and histopathological scores were significantly higher in Group 1 than in Groups 2, 3, and 4
2 context sentences(design, population, supporting numbers)
Summary · context
Mature New Zealand white rabbits (n=32) were randomly administered 2 mg collagenase type II twice in each knee joint.
Summary · context
Weekly injections of 0.6 mL saline (Group 1), 6 mg HA (Group 2), 0.25 mg AOD9604 (Group 3), and 0.25 mg AOD9604 with 6 mg HA (Group 4) were administered for 4-7 weeks after the first intra-articular collagenase injection.
Report a problemFND-2627569401
02AnimalAnimal study (in vivo)Efficacy outcome
In rabbits with collagenase-induced knee osteoarthritis, histopathological scores were significantly lower with AOD9604 alone than with saline.
In plain wordsIn rabbits with knee arthritis, cartilage tissue damage scores were lower with AOD9604 than with saline.
Peptide
AOD-9604
Outcome
DecreaseHistopathological score
Study
rabbitn: not reported in source
collagenase-induced knee osteoarthritis
Comparator
Saline (Group 1)
Outcome group
Bone and joint · Musculoskeletal
Studied dose
0.25 mg AOD9604 weekly · intra-articular · 4-7 weeksAs given in this study (rabbit).
Source sentences
Summary
Mean gross morphological and histopathological scores were significantly higher in Group 1 than in Groups 2, 3, and 4
2 context sentences(design, population, supporting numbers)
Summary · context
Mature New Zealand white rabbits (n=32) were randomly administered 2 mg collagenase type II twice in each knee joint.
Summary · context
Weekly injections of 0.6 mL saline (Group 1), 6 mg HA (Group 2), 0.25 mg AOD9604 (Group 3), and 0.25 mg AOD9604 with 6 mg HA (Group 4) were administered for 4-7 weeks after the first intra-articular collagenase injection.
Report a problemFND-2627569402
03AnimalAnimal study (in vivo)Efficacy outcome
In rabbits with collagenase-induced knee osteoarthritis, gross morphological scores were significantly lower with AOD9604 plus HA than with HA alone.
In plain wordsIn rabbits with knee arthritis, joint damage scores were lower with AOD9604 plus HA than with HA alone.
Peptide
AOD-9604
Outcome
DecreaseGross morphological score
Study
rabbitn: not reported in source
collagenase-induced knee osteoarthritis
Comparator
HA alone (Group 2)
Outcome group
Bone and joint · Musculoskeletal
Studied dose
0.25 mg AOD9604 with 6 mg HA weekly · intra-articular · 4-7 weeksAs given in this study (rabbit).
Source sentences
Summary
the scores were significantly lower in Group 4 than in Groups 2 and 3
2 context sentences(design, population, supporting numbers)
Summary · context
Mature New Zealand white rabbits (n=32) were randomly administered 2 mg collagenase type II twice in each knee joint.
Summary · context
Weekly injections of 0.6 mL saline (Group 1), 6 mg HA (Group 2), 0.25 mg AOD9604 (Group 3), and 0.25 mg AOD9604 with 6 mg HA (Group 4) were administered for 4-7 weeks after the first intra-articular collagenase injection.
Report a problemFND-2627569405
04AnimalAnimal study (in vivo)Efficacy outcome
In rabbits with collagenase-induced knee osteoarthritis, histopathological scores were significantly lower with AOD9604 plus HA than with HA alone.
In plain wordsIn rabbits with knee arthritis, cartilage tissue damage scores were lower with AOD9604 plus HA than with HA alone.
Peptide
AOD-9604
Outcome
DecreaseHistopathological score
Study
rabbitn: not reported in source
collagenase-induced knee osteoarthritis
Comparator
HA alone (Group 2)
Outcome group
Bone and joint · Musculoskeletal
Studied dose
0.25 mg AOD9604 with 6 mg HA weekly · intra-articular · 4-7 weeksAs given in this study (rabbit).
Source sentences
Summary
the scores were significantly lower in Group 4 than in Groups 2 and 3
2 context sentences(design, population, supporting numbers)
Summary · context
Mature New Zealand white rabbits (n=32) were randomly administered 2 mg collagenase type II twice in each knee joint.
Summary · context
Weekly injections of 0.6 mL saline (Group 1), 6 mg HA (Group 2), 0.25 mg AOD9604 (Group 3), and 0.25 mg AOD9604 with 6 mg HA (Group 4) were administered for 4-7 weeks after the first intra-articular collagenase injection.
Report a problemFND-2627569406
05AnimalAnimal study (in vivo)Efficacy outcome
In rabbits with collagenase-induced knee osteoarthritis, the lameness period was significantly shorter with AOD9604 alone than with saline.
In plain wordsIn rabbits with knee arthritis, lameness lasted a shorter time with AOD9604 than with saline.
Peptide
AOD-9604
Outcome
DecreaseLameness period
Study
rabbitn: not reported in source
collagenase-induced knee osteoarthritis
Comparator
Saline (Group 1)
Outcome group
Bone and joint · Musculoskeletal
Studied dose
0.25 mg AOD9604 weekly · intra-articular · 4-7 weeksAs given in this study (rabbit).
Source sentences
Summary
The lameness period in Group 1 was significantly longer than those in Groups 2 and 3.
2 context sentences(design, population, supporting numbers)
Summary · context
Mature New Zealand white rabbits (n=32) were randomly administered 2 mg collagenase type II twice in each knee joint.
Summary · context
Weekly injections of 0.6 mL saline (Group 1), 6 mg HA (Group 2), 0.25 mg AOD9604 (Group 3), and 0.25 mg AOD9604 with 6 mg HA (Group 4) were administered for 4-7 weeks after the first intra-articular collagenase injection.
Report a problemFND-2627569409
06AnimalAnimal study (in vivo)Efficacy outcome
In rabbits with collagenase-induced knee osteoarthritis, the lameness period was significantly shorter with AOD9604 plus HA than with HA alone.
In plain wordsIn rabbits with knee arthritis, lameness lasted a shorter time with AOD9604 plus HA than with HA alone.
Peptide
AOD-9604
Outcome
DecreaseLameness period
Study
rabbitn: not reported in source
collagenase-induced knee osteoarthritis
Comparator
HA alone (Group 2)
Outcome group
Bone and joint · Musculoskeletal
Studied dose
0.25 mg AOD9604 with 6 mg HA weekly · intra-articular · 4-7 weeksAs given in this study (rabbit).
Source sentences
Summary
The lameness period in Group 4 was significantly shorter than those in Groups 1, 2, and 3.
2 context sentences(design, population, supporting numbers)
Summary · context
Mature New Zealand white rabbits (n=32) were randomly administered 2 mg collagenase type II twice in each knee joint.
Summary · context
Weekly injections of 0.6 mL saline (Group 1), 6 mg HA (Group 2), 0.25 mg AOD9604 (Group 3), and 0.25 mg AOD9604 with 6 mg HA (Group 4) were administered for 4-7 weeks after the first intra-articular collagenase injection.
Report a problemFND-2627569411

Studies that did not test the peptide alone6

In this study, AOD-9604 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking AOD-9604.

07AnimalNot a test of AOD-9604 aloneAnimal study (in vivo)Efficacy outcome
In rabbits with collagenase-induced knee osteoarthritis, gross morphological scores were significantly lower with AOD9604 plus HA than with saline.
In plain wordsIn rabbits with knee arthritis, joint damage scores were lower with AOD9604 plus HA than with saline.
Peptide
AOD-9604
Outcome
DecreaseGross morphological score
Study
rabbitn: not reported in source
collagenase-induced knee osteoarthritis
Comparator
Saline (Group 1)
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
Mean gross morphological and histopathological scores were significantly higher in Group 1 than in Groups 2, 3, and 4
2 context sentences(design, population, supporting numbers)
Summary · context
Mature New Zealand white rabbits (n=32) were randomly administered 2 mg collagenase type II twice in each knee joint.
Summary · context
Weekly injections of 0.6 mL saline (Group 1), 6 mg HA (Group 2), 0.25 mg AOD9604 (Group 3), and 0.25 mg AOD9604 with 6 mg HA (Group 4) were administered for 4-7 weeks after the first intra-articular collagenase injection.
In this study, AOD-9604 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AOD-9604.
Report a problemFND-2627569403
08AnimalNot a test of AOD-9604 aloneAnimal study (in vivo)Efficacy outcome
In rabbits with collagenase-induced knee osteoarthritis, histopathological scores were significantly lower with AOD9604 plus HA than with saline.
In plain wordsIn rabbits with knee arthritis, cartilage tissue damage scores were lower with AOD9604 plus HA than with saline.
Peptide
AOD-9604
Outcome
DecreaseHistopathological score
Study
rabbitn: not reported in source
collagenase-induced knee osteoarthritis
Comparator
Saline (Group 1)
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
Mean gross morphological and histopathological scores were significantly higher in Group 1 than in Groups 2, 3, and 4
2 context sentences(design, population, supporting numbers)
Summary · context
Mature New Zealand white rabbits (n=32) were randomly administered 2 mg collagenase type II twice in each knee joint.
Summary · context
Weekly injections of 0.6 mL saline (Group 1), 6 mg HA (Group 2), 0.25 mg AOD9604 (Group 3), and 0.25 mg AOD9604 with 6 mg HA (Group 4) were administered for 4-7 weeks after the first intra-articular collagenase injection.
In this study, AOD-9604 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AOD-9604.
Report a problemFND-2627569404
09AnimalNot a test of AOD-9604 aloneAnimal study (in vivo)Efficacy outcome
In rabbits with collagenase-induced knee osteoarthritis, gross morphological scores were significantly lower with AOD9604 plus HA than with AOD9604 alone.
In plain wordsIn rabbits with knee arthritis, joint damage scores were lower with AOD9604 plus HA than with AOD9604 alone.
Peptide
AOD-9604
Outcome
DecreaseGross morphological score
Study
rabbitn: not reported in source
collagenase-induced knee osteoarthritis
Comparator
AOD9604 alone (Group 3)
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
the scores were significantly lower in Group 4 than in Groups 2 and 3
2 context sentences(design, population, supporting numbers)
Summary · context
Mature New Zealand white rabbits (n=32) were randomly administered 2 mg collagenase type II twice in each knee joint.
Summary · context
Weekly injections of 0.6 mL saline (Group 1), 6 mg HA (Group 2), 0.25 mg AOD9604 (Group 3), and 0.25 mg AOD9604 with 6 mg HA (Group 4) were administered for 4-7 weeks after the first intra-articular collagenase injection.
In this study, AOD-9604 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AOD-9604.
Report a problemFND-2627569407
10AnimalNot a test of AOD-9604 aloneAnimal study (in vivo)Efficacy outcome
In rabbits with collagenase-induced knee osteoarthritis, histopathological scores were significantly lower with AOD9604 plus HA than with AOD9604 alone.
In plain wordsIn rabbits with knee arthritis, cartilage tissue damage scores were lower with AOD9604 plus HA than with AOD9604 alone.
Peptide
AOD-9604
Outcome
DecreaseHistopathological score
Study
rabbitn: not reported in source
collagenase-induced knee osteoarthritis
Comparator
AOD9604 alone (Group 3)
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
the scores were significantly lower in Group 4 than in Groups 2 and 3
2 context sentences(design, population, supporting numbers)
Summary · context
Mature New Zealand white rabbits (n=32) were randomly administered 2 mg collagenase type II twice in each knee joint.
Summary · context
Weekly injections of 0.6 mL saline (Group 1), 6 mg HA (Group 2), 0.25 mg AOD9604 (Group 3), and 0.25 mg AOD9604 with 6 mg HA (Group 4) were administered for 4-7 weeks after the first intra-articular collagenase injection.
In this study, AOD-9604 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AOD-9604.
Report a problemFND-2627569408
11AnimalNot a test of AOD-9604 aloneAnimal study (in vivo)Efficacy outcome
In rabbits with collagenase-induced knee osteoarthritis, the lameness period was significantly shorter with AOD9604 plus HA than with saline.
In plain wordsIn rabbits with knee arthritis, lameness lasted a shorter time with AOD9604 plus HA than with saline.
Peptide
AOD-9604
Outcome
DecreaseLameness period
Study
rabbitn: not reported in source
collagenase-induced knee osteoarthritis
Comparator
Saline (Group 1)
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
The lameness period in Group 4 was significantly shorter than those in Groups 1, 2, and 3.
2 context sentences(design, population, supporting numbers)
Summary · context
Mature New Zealand white rabbits (n=32) were randomly administered 2 mg collagenase type II twice in each knee joint.
Summary · context
Weekly injections of 0.6 mL saline (Group 1), 6 mg HA (Group 2), 0.25 mg AOD9604 (Group 3), and 0.25 mg AOD9604 with 6 mg HA (Group 4) were administered for 4-7 weeks after the first intra-articular collagenase injection.
In this study, AOD-9604 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AOD-9604.
Report a problemFND-2627569410
12AnimalNot a test of AOD-9604 aloneAnimal study (in vivo)Efficacy outcome
In rabbits with collagenase-induced knee osteoarthritis, the lameness period was significantly shorter with AOD9604 plus HA than with AOD9604 alone.
In plain wordsIn rabbits with knee arthritis, lameness lasted a shorter time with AOD9604 plus HA than with AOD9604 alone.
Peptide
AOD-9604
Outcome
DecreaseLameness period
Study
rabbitn: not reported in source
collagenase-induced knee osteoarthritis
Comparator
AOD9604 alone (Group 3)
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
The lameness period in Group 4 was significantly shorter than those in Groups 1, 2, and 3.
2 context sentences(design, population, supporting numbers)
Summary · context
Mature New Zealand white rabbits (n=32) were randomly administered 2 mg collagenase type II twice in each knee joint.
Summary · context
Weekly injections of 0.6 mL saline (Group 1), 6 mg HA (Group 2), 0.25 mg AOD9604 (Group 3), and 0.25 mg AOD9604 with 6 mg HA (Group 4) were administered for 4-7 weeks after the first intra-articular collagenase injection.
In this study, AOD-9604 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking AOD-9604.
Report a problemFND-2627569412

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
9 Oct 2026, 18:17 UTC
Study results updated
Version 1
9 Oct 2026, 02:47 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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