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Study · Randomized controlled trial · n = 97 · 2016

4 results

Oxytocin Facilitates Pavlovian Fear Learning in Males.

Eckstein M, Scheele D, Patin A, Preckel K, Becker B, Walter A, Domschke K, Grinevich V, Maier W, Hurlemann R

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology14 Aug 2015Cited by 67 (Europe PMC)

PMID26272050 (opens in a new tab)PMCIDPMC4748433 (opens in a new tab)DOI10.1038/npp.2015.245 (opens in a new tab)PepBankPUB-26272050
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In healthy men, intranasal oxytocin led to faster task-related responses to fear-associated stimuli in the late phase of Pavlovian fear conditioning.

    In plain wordsIn healthy men, oxytocin made responses in a fear-learning task faster in the late phase of learning.

    Peptide
    Oxytocin
    Outcome
    IncreaseSpeed of task-related responses in late fear conditioning
    Study

    n = 97

    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Specifically, subjects exhibited faster task-related responses and enhanced SCRs to fear-associated stimuli in the late phase of conditioning, which was paralleled by heightened activity in cingulate cortex subregions in the absence of changes in amygdala function.
    1 context sentence
    Summary · context
    In the present randomized controlled study involving 97 healthy male subjects, we therefore employed functional magnetic resonance imaging and simultaneous skin conductance response (SCR) measures to characterize the modulatory influence of intranasal oxytocin (24 IU) on Pavlovian fear conditioning.
  2. 02HumanRandomized controlled trialMechanism

    In healthy men, intranasal oxytocin enhanced skin conductance responses to fear-associated stimuli in the late phase of Pavlovian fear conditioning.

    In plain wordsIn healthy men, oxytocin increased body arousal responses to fear-linked cues in the late phase of fear learning.

    Peptide
    Oxytocin
    Outcome
    IncreaseSkin conductance response to fear-associated stimuli in late conditioning
    Study

    n = 97

    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Specifically, subjects exhibited faster task-related responses and enhanced SCRs to fear-associated stimuli in the late phase of conditioning, which was paralleled by heightened activity in cingulate cortex subregions in the absence of changes in amygdala function.
    1 context sentence
    Summary · context
    In the present randomized controlled study involving 97 healthy male subjects, we therefore employed functional magnetic resonance imaging and simultaneous skin conductance response (SCR) measures to characterize the modulatory influence of intranasal oxytocin (24 IU) on Pavlovian fear conditioning.
  3. 03HumanRandomized controlled trialMechanism

    In healthy men, intranasal oxytocin increased activity in cingulate cortex subregions during Pavlovian fear conditioning.

    In plain wordsIn healthy men, oxytocin raised activity in parts of the cingulate cortex during fear learning.

    Peptide
    Oxytocin
    Outcome
    IncreaseCingulate cortex subregion activity during fear conditioning
    Study

    n = 97

    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Specifically, subjects exhibited faster task-related responses and enhanced SCRs to fear-associated stimuli in the late phase of conditioning, which was paralleled by heightened activity in cingulate cortex subregions in the absence of changes in amygdala function.
    1 context sentence
    Summary · context
    In the present randomized controlled study involving 97 healthy male subjects, we therefore employed functional magnetic resonance imaging and simultaneous skin conductance response (SCR) measures to characterize the modulatory influence of intranasal oxytocin (24 IU) on Pavlovian fear conditioning.
  4. 04HumanRandomized controlled trialMechanism

    In healthy men, intranasal oxytocin did not change amygdala function during Pavlovian fear conditioning.

    In plain wordsIn healthy men, oxytocin did not change amygdala activity during fear learning.

    Peptide
    Oxytocin
    Outcome
    No significant changeAmygdala function during fear conditioning
    Study

    n = 97

    Outcome group
    Brain and neuronal activity · Nervous system and cognition
    Studied dose
    24 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    Specifically, subjects exhibited faster task-related responses and enhanced SCRs to fear-associated stimuli in the late phase of conditioning, which was paralleled by heightened activity in cingulate cortex subregions in the absence of changes in amygdala function.
    1 context sentence
    Summary · context
    In the present randomized controlled study involving 97 healthy male subjects, we therefore employed functional magnetic resonance imaging and simultaneous skin conductance response (SCR) measures to characterize the modulatory influence of intranasal oxytocin (24 IU) on Pavlovian fear conditioning.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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