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Study · In vitro (cells) · rat · 2015

4 results

Mechano growth factor E peptide promotes rat bone marrow-derived mesenchymal stem cell migration through CXCR4-ERK1/2.

Luo Q, Wu K, Zhang B, Song G

Growth factors (Chur, Switzerland)1 Jan 2015Cited by 7 (Europe PMC)

PMID26260632 (opens in a new tab)DOI10.3109/08977194.2015.1058258 (opens in a new tab)PepBankPUB-26260632
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In rat bone marrow-derived mesenchymal stem cells, MGF-25E induced migration by modulating CXCR4 to activate the ERK1/2 pathway.

    In plain wordsIn rat cells, the MGF-25E peptide made stem cells move, through a CXCR4 and ERK1/2 signal.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaserMSC migration
    Study

    ratn: not reported in source

    rat bone marrow-derived mesenchymal stem cells
    Outcome group
    Cancer cell invasion and metastasis · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In the present study, we determined that MGF-25E induced the migration of rMSCs by modulating CXCR4 to activate the ERK1/2 pathway.
  2. 02LabIn vitro (cells)Mechanism

    In rat bone marrow-derived mesenchymal stem cells, MGF-25E modulated CXCR4 to activate the ERK1/2 pathway.

    In plain wordsIn rat cells, MGF-25E switched on the ERK1/2 signal through CXCR4.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseCXCR4-ERK1/2 pathway activation
    Study

    ratn: not reported in source

    rat bone marrow-derived mesenchymal stem cells
    Outcome group
    Receptor activity and mechanism · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In the present study, we determined that MGF-25E induced the migration of rMSCs by modulating CXCR4 to activate the ERK1/2 pathway.
  3. 03LabIn vitro (cells)Mechanism

    In rat bone marrow-derived mesenchymal stem cells, MGF-25E increased cell stiffness through activation of the CXCR4-ERK1/2 pathway.

    In plain wordsIn rat cells, MGF-25E made stem cells stiffer, through the CXCR4 and ERK1/2 signal.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaserMSC stiffness (Young's modulus)
    Study

    ratn: not reported in source

    rat bone marrow-derived mesenchymal stem cells
    Outcome group
    Cancer cell invasion and metastasis · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The analysis of the Young's modulus and F-actin remodeling indicated that MGF-25E increased the stiffness and the F-actin polymerization of rMSCs through the activation of the CXCR4-ERK1/2 pathway.
  4. 04LabIn vitro (cells)Mechanism

    In rat bone marrow-derived mesenchymal stem cells, MGF-25E increased F-actin polymerization through activation of the CXCR4-ERK1/2 pathway.

    In plain wordsIn rat cells, MGF-25E increased the building of the cell skeleton protein F-actin, through the CXCR4 and ERK1/2 signal.

    Peptide
    MGF / PEG-MGF
    Outcome
    IncreaseF-actin polymerization
    Study

    ratn: not reported in source

    rat bone marrow-derived mesenchymal stem cells
    Outcome group
    Cancer cell invasion and metastasis · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The analysis of the Young's modulus and F-actin remodeling indicated that MGF-25E increased the stiffness and the F-actin polymerization of rMSCs through the activation of the CXCR4-ERK1/2 pathway.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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