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Study · Randomized controlled trial · n = 58 · 2016

4 results

Sex-Steroid Hormone Manipulation Reduces Brain Response to Reward.

Macoveanu J, Henningsson S, Pinborg A, Jensen P, Knudsen GM, Frokjaer VG, Siebner HR

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology6 Aug 2015Cited by 43 (Europe PMC)

PMID26245498 (opens in a new tab)PMCIDPMC4748430 (opens in a new tab)DOI10.1038/npp.2015.236 (opens in a new tab)PepBankPUB-26245498
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanRandomized controlled trialMechanism

    In healthy women, goserelin reduced amygdala reactivity to high monetary rewards versus placebo.

    In plain wordsIn healthy women, goserelin reduced the amygdala response to high monetary rewards compared with placebo.

    Peptide
    Goserelin
    Outcome
    DecreaseAmygdala reactivity to high monetary rewards
    Study

    n = 58

    Comparator
    Placebo
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Compared with placebo, GnRHa reduced amygdala's reactivity to high monetary rewards.
    2 context sentences
    Summary · context
    In a double-blinded placebo controlled study, healthy women were randomized to receive either placebo or the gonadotropin-releasing hormone agonist (GnRHa) goserelin, which causes a net decrease in sex-steroid levels.
    Summary · context
    Fifty-eight women performed a gambling task while undergoing functional MRI at baseline, during the mid-follicular phase, and again following the intervention.
  2. 02HumanNon-randomized trialActivity measurement

    In healthy women, goserelin caused a net reduction in estradiol.

    In plain wordsIn healthy women, goserelin lowered estradiol.

    Peptide
    Goserelin
    Outcome
    DecreaseEstradiol
    Study

    n: not reported in source

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The GnRHa intervention caused a net reduction in ovarian sex steroids (estradiol and testosterone) and increased depression symptoms.
    2 context sentences
    Summary · context
    In a double-blinded placebo controlled study, healthy women were randomized to receive either placebo or the gonadotropin-releasing hormone agonist (GnRHa) goserelin, which causes a net decrease in sex-steroid levels.
    Summary · context
    Fifty-eight women performed a gambling task while undergoing functional MRI at baseline, during the mid-follicular phase, and again following the intervention.
  3. 03HumanNon-randomized trialActivity measurement

    In healthy women, goserelin caused a net reduction in testosterone.

    In plain wordsIn healthy women, goserelin lowered testosterone.

    Peptide
    Goserelin
    Outcome
    DecreaseTestosterone
    Study

    n: not reported in source

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The GnRHa intervention caused a net reduction in ovarian sex steroids (estradiol and testosterone) and increased depression symptoms.
    2 context sentences
    Summary · context
    In a double-blinded placebo controlled study, healthy women were randomized to receive either placebo or the gonadotropin-releasing hormone agonist (GnRHa) goserelin, which causes a net decrease in sex-steroid levels.
    Summary · context
    Fifty-eight women performed a gambling task while undergoing functional MRI at baseline, during the mid-follicular phase, and again following the intervention.
  4. 04HumanNon-randomized trialSafety outcome

    In healthy women, goserelin increased depression symptoms.

    In plain wordsIn healthy women, goserelin increased depression symptoms.

    Peptide
    Goserelin
    Outcome
    IncreaseDepression symptoms
    Study

    n: not reported in source

    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The GnRHa intervention caused a net reduction in ovarian sex steroids (estradiol and testosterone) and increased depression symptoms.
    2 context sentences
    Summary · context
    In a double-blinded placebo controlled study, healthy women were randomized to receive either placebo or the gonadotropin-releasing hormone agonist (GnRHa) goserelin, which causes a net decrease in sex-steroid levels.
    Summary · context
    Fifty-eight women performed a gambling task while undergoing functional MRI at baseline, during the mid-follicular phase, and again following the intervention.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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