Skip to content

Study · Randomized controlled trial · n = 31 · 2015

2 results

Effects of adverse childhood experiences on the association between intranasal oxytocin and social stress reactivity among individuals with cocaine dependence.

Flanagan JC, Baker NL, McRae-Clark AL, Brady KT, Moran-Santa Maria MM

Psychiatry research23 Jul 2015Cited by 44 (Europe PMC)

PMID26231584 (opens in a new tab)PMCIDPMC4546857 (opens in a new tab)DOI10.1016/j.psychres.2015.07.064 (opens in a new tab)PepBankPUB-26231584
Source linkPubMedAsk about this study
Jump to 2 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In cocaine-dependent adults, adverse childhood experience scores modified the relationship between intranasal oxytocin and cortisol reactivity to social stress.

    In plain wordsIn people dependent on cocaine, childhood adversity changed how nasal oxytocin related to the cortisol response to social stress.

    Peptide
    Oxytocin
    Outcome
    Not applicableCortisol reactivity to social stress by ACE score
    Study

    n = 31

    Comparator
    Placebo
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    40 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    ACE scores modified the relationship between intranasal oxytocin and cortisol reactivity.
    1 context sentence
    Summary · context
    This study employed a double-blind, placebo-controlled design to examine the extent to which ACE influenced the effects of intranasal oxytocin (40IU) on neuroendocrine reactivity to a laboratory social stress paradigm in a sample of 31 cocaine-dependent individuals.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In cocaine-dependent adults, the modifying effect of adverse childhood experiences on the oxytocin and DHEA response was in a similar direction to cortisol but not statistically significant.

    In plain wordsIn people dependent on cocaine, childhood adversity did not significantly change how nasal oxytocin related to the DHEA stress response.

    Peptide
    Oxytocin
    Outcome
    No significant changeDHEA response to social stress by ACE score
    Study

    n = 31

    Comparator
    Placebo
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    40 IU · intranasalAs given in this study (human).

    Source sentences

    Summary
    While ACE modified the relationship between intranasal oxytocin and DHEA response in a similar direction to what was seen in cortisol, it did not reach statistical significance.
    1 context sentence
    Summary · context
    This study employed a double-blind, placebo-controlled design to examine the extent to which ACE influenced the effects of intranasal oxytocin (40IU) on neuroendocrine reactivity to a laboratory social stress paradigm in a sample of 31 cocaine-dependent individuals.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 01:30 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:49 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.