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Study · Animal study (in vivo) · mouse · 2016

8 results

Differential effects of isomers of clomiphene citrate on reproductive tissues in male mice.

Fontenot GK, Wiehle RD, Podolski JS

BJU international7 Sept 2015Cited by 13 (Europe PMC)

PMID26220499 (opens in a new tab)DOI10.1111/bju.13244 (opens in a new tab)PepBankPUB-26220499
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In male mice, isolated enclomiphene had positive effects on testosterone production.

    In plain wordsIn mice, isolated enclomiphene had positive effects on testosterone production.

    Peptide
    Enclomiphene
    Outcome
    IncreaseTestosterone production
    Study

    mousen: not reported in source

    Male mice in chronic oral toxicity study
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    4 or 40 mg/kg/day · oral gavageAs given in this study (mouse).

    Source sentences

    Summary
    Treatment with the isolated enclomiphene isomer had positive effects on testosterone production and no effects on testicular histology.
    2 context sentences
    Summary · context
    To determine, in a chronic dosing study, the oral toxicity potential of the test substances, enclomiphene citrate (ENC) and zuclomiphene citrate (ZUC), when administered to male mice by oral gavage.
    Summary · context
    Group I, placebo; Group II, 40 mg/kg body weight/day ENC; Group III, 4 mg/kg/day ENC; Group IV, 40 mg/kg/day ZUC; Group V, 4 mg/kg/day ZUC.
  2. 02AnimalAnimal study (in vivo)Safety outcome

    In male mice, isolated enclomiphene did not affect testicular histology.

    In plain wordsIn mice, isolated enclomiphene did not change testicular tissue structure.

    Peptide
    Enclomiphene
    Outcome
    No significant changeTesticular histology
    Study

    mousen: not reported in source

    Male mice in chronic oral toxicity study
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    4 or 40 mg/kg/day · oral gavageAs given in this study (mouse).

    Source sentences

    Summary
    Treatment with the isolated enclomiphene isomer had positive effects on testosterone production and no effects on testicular histology.
    2 context sentences
    Summary · context
    To determine, in a chronic dosing study, the oral toxicity potential of the test substances, enclomiphene citrate (ENC) and zuclomiphene citrate (ZUC), when administered to male mice by oral gavage.
    Summary · context
    Group I, placebo; Group II, 40 mg/kg body weight/day ENC; Group III, 4 mg/kg/day ENC; Group IV, 40 mg/kg/day ZUC; Group V, 4 mg/kg/day ZUC.
  3. 03AnimalAnimal study (in vivo)Safety outcome

    In male mice, profound Leydig cell effects were associated only with zuclomiphene, rather than enclomiphene.

    In plain wordsIn mice, profound Leydig cell effects occurred only with zuclomiphene, rather than enclomiphene.

    Peptide
    Enclomiphene
    Outcome
    No significant changeLeydig cell effects
    Study

    mousen: not reported in source

    Male mice in chronic oral toxicity study
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    4 or 40 mg/kg/day · oral gavageAs given in this study (mouse).

    Source sentences

    Summary
    In this chronic dosing study in mice, profound effects on Leydig cells, epididymis, seminal vesicles, and kidneys were seen, as well as effects on serum testosterone, follicle-stimulating hormone and luteinising hormone levels that were associated with ZUC treatment only.
    2 context sentences
    Summary · context
    To determine, in a chronic dosing study, the oral toxicity potential of the test substances, enclomiphene citrate (ENC) and zuclomiphene citrate (ZUC), when administered to male mice by oral gavage.
    Summary · context
    Group I, placebo; Group II, 40 mg/kg body weight/day ENC; Group III, 4 mg/kg/day ENC; Group IV, 40 mg/kg/day ZUC; Group V, 4 mg/kg/day ZUC.
  4. 04AnimalAnimal study (in vivo)Safety outcome

    In male mice, profound epididymal effects were associated only with zuclomiphene, rather than enclomiphene.

    In plain wordsIn mice, profound epididymal effects occurred only with zuclomiphene, rather than enclomiphene.

    Peptide
    Enclomiphene
    Outcome
    No significant changeEpididymal effects
    Study

    mousen: not reported in source

    Male mice in chronic oral toxicity study
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    4 or 40 mg/kg/day · oral gavageAs given in this study (mouse).

    Source sentences

    Summary
    In this chronic dosing study in mice, profound effects on Leydig cells, epididymis, seminal vesicles, and kidneys were seen, as well as effects on serum testosterone, follicle-stimulating hormone and luteinising hormone levels that were associated with ZUC treatment only.
    2 context sentences
    Summary · context
    To determine, in a chronic dosing study, the oral toxicity potential of the test substances, enclomiphene citrate (ENC) and zuclomiphene citrate (ZUC), when administered to male mice by oral gavage.
    Summary · context
    Group I, placebo; Group II, 40 mg/kg body weight/day ENC; Group III, 4 mg/kg/day ENC; Group IV, 40 mg/kg/day ZUC; Group V, 4 mg/kg/day ZUC.
  5. 05AnimalAnimal study (in vivo)Safety outcome

    In male mice, profound seminal vesicle effects were associated only with zuclomiphene, rather than enclomiphene.

    In plain wordsIn mice, profound seminal vesicle effects occurred only with zuclomiphene, rather than enclomiphene.

    Peptide
    Enclomiphene
    Outcome
    No significant changeSeminal vesicle effects
    Study

    mousen: not reported in source

    Male mice in chronic oral toxicity study
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    4 or 40 mg/kg/day · oral gavageAs given in this study (mouse).

    Source sentences

    Summary
    In this chronic dosing study in mice, profound effects on Leydig cells, epididymis, seminal vesicles, and kidneys were seen, as well as effects on serum testosterone, follicle-stimulating hormone and luteinising hormone levels that were associated with ZUC treatment only.
    2 context sentences
    Summary · context
    To determine, in a chronic dosing study, the oral toxicity potential of the test substances, enclomiphene citrate (ENC) and zuclomiphene citrate (ZUC), when administered to male mice by oral gavage.
    Summary · context
    Group I, placebo; Group II, 40 mg/kg body weight/day ENC; Group III, 4 mg/kg/day ENC; Group IV, 40 mg/kg/day ZUC; Group V, 4 mg/kg/day ZUC.
  6. 06AnimalAnimal study (in vivo)Safety outcome

    In male mice, profound kidney effects were associated only with zuclomiphene, rather than enclomiphene.

    In plain wordsIn mice, profound kidney effects occurred only with zuclomiphene, rather than enclomiphene.

    Peptide
    Enclomiphene
    Outcome
    No significant changeKidney effects
    Study

    mousen: not reported in source

    Male mice in chronic oral toxicity study
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    4 or 40 mg/kg/day · oral gavageAs given in this study (mouse).

    Source sentences

    Summary
    In this chronic dosing study in mice, profound effects on Leydig cells, epididymis, seminal vesicles, and kidneys were seen, as well as effects on serum testosterone, follicle-stimulating hormone and luteinising hormone levels that were associated with ZUC treatment only.
    2 context sentences
    Summary · context
    To determine, in a chronic dosing study, the oral toxicity potential of the test substances, enclomiphene citrate (ENC) and zuclomiphene citrate (ZUC), when administered to male mice by oral gavage.
    Summary · context
    Group I, placebo; Group II, 40 mg/kg body weight/day ENC; Group III, 4 mg/kg/day ENC; Group IV, 40 mg/kg/day ZUC; Group V, 4 mg/kg/day ZUC.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In male mice, FSH effects were associated only with zuclomiphene, rather than enclomiphene.

    In plain wordsIn mice, FSH effects occurred only with zuclomiphene, rather than enclomiphene.

    Peptide
    Enclomiphene
    Outcome
    No significant changeFSH levels
    Study

    mousen: not reported in source

    Male mice in chronic oral toxicity study
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    4 or 40 mg/kg/day · oral gavageAs given in this study (mouse).

    Source sentences

    Summary
    In this chronic dosing study in mice, profound effects on Leydig cells, epididymis, seminal vesicles, and kidneys were seen, as well as effects on serum testosterone, follicle-stimulating hormone and luteinising hormone levels that were associated with ZUC treatment only.
    2 context sentences
    Summary · context
    To determine, in a chronic dosing study, the oral toxicity potential of the test substances, enclomiphene citrate (ENC) and zuclomiphene citrate (ZUC), when administered to male mice by oral gavage.
    Summary · context
    Group I, placebo; Group II, 40 mg/kg body weight/day ENC; Group III, 4 mg/kg/day ENC; Group IV, 40 mg/kg/day ZUC; Group V, 4 mg/kg/day ZUC.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In male mice, LH effects were associated only with zuclomiphene, rather than enclomiphene.

    In plain wordsIn mice, LH effects occurred only with zuclomiphene, rather than enclomiphene.

    Peptide
    Enclomiphene
    Outcome
    No significant changeLH levels
    Study

    mousen: not reported in source

    Male mice in chronic oral toxicity study
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    4 or 40 mg/kg/day · oral gavageAs given in this study (mouse).

    Source sentences

    Summary
    In this chronic dosing study in mice, profound effects on Leydig cells, epididymis, seminal vesicles, and kidneys were seen, as well as effects on serum testosterone, follicle-stimulating hormone and luteinising hormone levels that were associated with ZUC treatment only.
    2 context sentences
    Summary · context
    To determine, in a chronic dosing study, the oral toxicity potential of the test substances, enclomiphene citrate (ENC) and zuclomiphene citrate (ZUC), when administered to male mice by oral gavage.
    Summary · context
    Group I, placebo; Group II, 40 mg/kg body weight/day ENC; Group III, 4 mg/kg/day ENC; Group IV, 40 mg/kg/day ZUC; Group V, 4 mg/kg/day ZUC.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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